Relative bioavailability and bioequivalence of famciclovir tablets in healthy volunteers

科研成果详情

题名	Relative bioavailability and bioequivalence of famciclovir tablets in healthy volunteers
作者	Xu, Xue-Gu1; Jiang, Hai-Yan ; Zhang, Xiu-Hua 2; Hu, Guo-Xin1; Dai, Zong-Shun 3
发表日期	2009-12-01
发表期刊	Chinese Journal of New Drugs 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Bioequivalence Famciclovir High performance liquid chromatography Penciclovir Pharmacokinetics Relative bioavailability
摘要	Objective: To study the relative bioavailability and bioequivalence of famciclovir tablets in healthy volunteers. Methods: A single oral dose of 0.5 g famciclovir (test or reference tablets) was administered to 18 healthy volunteers in a randomised crossover study. The concentrations of penciclovir in plasma were determined by HPLC. The pharmacokinetic parameters were calculated, and the relative bioavailability and bioequivalence of two tablets were evaluated by DAS program. Results: After single doses of test and reference tablets, the pharmacokinetic parameters of penciclovir were as follows: C max, (3.05 ± 0.73) and (3.16 ± 0.99) mg·L -1; Tmax, (1.03 ± 0.47) and (1.15 ± 0.62) h; AUC0-12, (9.11 ± 2.75) and (9.53 ± 2.68) mg·h·L-1; AUC0-inf, (9.49 ± 2.98) and (9.89 ± 2.76) mg·h·L-1, respectively. The 90% confidential intervals of AUC0-12, AUC0-inf and C max of test tablets were 87.7%-103.7%, 87.9%-103.8% and 91.4%-106.4%, respectively. Conclusion: The relative bioavailability is (97.9 ± 22.6)%; the two famciclovir tablets are bioequivalent.
ISSN	1003-3734
卷号	18 期号:17
收录类别	SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-77954520868
通讯作者地址	[Xu, Xue-Gu]Department of Pharmacology,Wenzhou Medical College,China
Scopus学科分类	Pharmacology, Toxicology and Pharmaceutics (all);Pharmacology (medical)
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/97693
专题	药学院（分析测试中心）_临床药学与药理系温州医科大学
通讯作者	Xu, Xue-Gu
作者单位	1.Department of Pharmacology,Wenzhou Medical College,China; 2.Wenzhou Medical College,China; 3.Institute of Clinical Pharmacology,Tongji Medical College,Huazhong University of Science and Technology,China
第一作者单位	药学院（分析测试中心）_临床药学与药理系
通讯作者单位	药学院（分析测试中心）_临床药学与药理系
第一作者的第一单位	药学院（分析测试中心）_临床药学与药理系
推荐引用方式 GB/T 7714	Xu, Xue-Gu,Jiang, Hai-Yan,Zhang, Xiu-Hua,et al. Relative bioavailability and bioequivalence of famciclovir tablets in healthy volunteers[J]. Chinese Journal of New Drugs,2009,18(17).
APA	Xu, Xue-Gu, Jiang, Hai-Yan, Zhang, Xiu-Hua, Hu, Guo-Xin, & Dai, Zong-Shun. (2009). Relative bioavailability and bioequivalence of famciclovir tablets in healthy volunteers. Chinese Journal of New Drugs, 18(17).
MLA	Xu, Xue-Gu,et al."Relative bioavailability and bioequivalence of famciclovir tablets in healthy volunteers".Chinese Journal of New Drugs 18.17(2009).

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