Regulating effects of Paecilomyces cicadae polysaccharides on immunity of aged rats

科研成果详情

题名	Regulating effects of Paecilomyces cicadae polysaccharides on immunity of aged rats
作者	Yang, Jie-Zuan 1; Zhuo, Jia2; Chen, Bo-Kun2; Jin, Li-Qin3; Lv, Jian-Xin2; Li, Lan-Juan 1
发表日期	2008-02-01
发表期刊	Zhongguo Zhongyao Zazhi 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Immunity Macrophages Paecilomyces cicadae Polysaccharides Proliferative activity
摘要	Objective: To investigate the effects of Paecilomyces cicadae polysaccharide (PCPS) on the immunological function of aged rats in vivo. Method: The young and old rats were administered with normal saline as control groups, and the rats from test group were sc given 50,100, 200 mg · kg-1 · d-1 dosage of PCPS for 3 weeks. The phagocytizing rate and index of PMφ, AMφ to S. aureas were observed, and the colorimetric MTT was used to analyze the proliferative activity of spleenocytes which had been stimulated with ConA or LPS. We also inspected the ability varing of ACP, LDH, ARG of spleen, and observed the ultramicro structure of spleen under the SEM. Result: The phagocytosis of Mφ was lower in aged group than that in young' s group, and the proliferative activity of spleenocytes was lower too. The activities of ACP, LDH, ARG of spleen were extremely decreased (P <0. 01) in aged rats as well. The proliferative activity and phagocytotic rate were both extremely increased in PCPS groups (P <0. 01), and the mitochondrion and endoplasmic reticulum of spleen were accrementition as well (P <0. 01). Conclusion: PCPS could enhance the phagocytizing function of PMφ, AMφ of aged rats in vivo, and strengthen the immune function-of spleen and its proliferative activity as well. Then the immunity of aged rats could be improved. The PCPS may be an anti-aging agent.
ISSN	1001-5302
卷号	33 期号:3 页码:292-295
收录类别	SCOPUS
URL	查看原文
PubMed ID	18536469
SCOPUSEID	2-s2.0-42249116143
通讯作者地址	[Yang, Jie-Zuan]Department of Infectious Diseases,First Affiliated Hospital,Zhejiang University,China
Scopus学科分类	Pharmacology, Toxicology and Pharmaceutics (all);Complementary and Alternative Medicine;Pharmacology (medical)
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/97445
专题	基础医学院（机能实验教学中心）_生物科学系_生物化学与分子生物学
通讯作者	Yang, Jie-Zuan
作者单位	1.Department of Infectious Diseases,First Affiliated Hospital,Zhejiang University,China; 2.Department of Life Science,Wenzhou Medical College,China; 3.Department of Biochemistry,Wenzhou Medical College,China
推荐引用方式 GB/T 7714	Yang, Jie-Zuan,Zhuo, Jia,Chen, Bo-Kun,et al. Regulating effects of Paecilomyces cicadae polysaccharides on immunity of aged rats[J]. Zhongguo Zhongyao Zazhi,2008,33(3):292-295.
APA	Yang, Jie-Zuan, Zhuo, Jia, Chen, Bo-Kun, Jin, Li-Qin, Lv, Jian-Xin, & Li, Lan-Juan. (2008). Regulating effects of Paecilomyces cicadae polysaccharides on immunity of aged rats. Zhongguo Zhongyao Zazhi, 33(3), 292-295.
MLA	Yang, Jie-Zuan,et al."Regulating effects of Paecilomyces cicadae polysaccharides on immunity of aged rats".Zhongguo Zhongyao Zazhi 33.3(2008):292-295.

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