Nuclear expression and/or reduced membranous expression of beta-catenin correlate with poor prognosis in colorectal carcinoma A meta-analysis

doi:10.1097/MD.0000000000005546

科研成果详情

题名	Nuclear expression and/or reduced membranous expression of beta-catenin correlate with poor prognosis in colorectal carcinoma A meta-analysis
作者	Zhang, Shizhen 1; Wang, Zhen 1; Shan, Jinlan 1; Yu, Xiuyan 1; Li, Ling 2; Lei, Rui 3; Lin, Daozhe 4; Guan, Siqi 5; Wang, Xiaochen 1
发表日期	2016-12
发表期刊	MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	beta-catenin colorectal cancer meta-analysis prognosis
其他关键词	E-CADHERIN EXPRESSION ; COLON-CANCER ; TISSUE MICROARRAY ; IMMUNOHISTOCHEMICAL EXPRESSION ; HEPATOCELLULAR-CARCINOMA ; INVASIVE FRONT ; CYCLIN D1 ; SURVIVAL ; WNT ; PROGRESSION
摘要	Background: The differential subcellular localizations of beta-catenin (including membrane, cytoplasm, and nucleus) play different roles in the progression of colorectal cancer (CRC). However, the correlation between each subcellular localization of beta-catenin and the prognosis of CRC patients remains undetermined. Methods: Systematic strategies were applied to search for eligible published studies in the PubMed, Embase, and Web of Science databases. The correlation between each subcellular localizations of beta-catenin expression and patients' clinicopathological features or prognosis was analyzed. Results: Finally, this meta-analysis, including 6238 cases from 34 studies, revealed that beta-catenin overexpression in the nucleus (HR: 1.50[95% CI: 1.08-2.10]) or reduced expression of beta-catenin in the membrane (HR: 1.33[95% CI: 1.15-1.54]) significantly correlated with lower 5-year overall survival (OS). Conversely, overexpression of beta-catenin in the cytoplasm (HR: 1.00[95% CI: 0.85-1.18]) did not show significant association with 5-year OS. Conclusion: This study suggested that beta-catenin overexpression in the nucleus or reduced expression in the membrane, but not its overexpression in cytoplasm, could serve as a valuable prognostic predictor for CRC. However, additional large and well-designed prospective studies are required to verify our results.
资助项目	Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LY12H16014, LY13H160014, LY14H160043]; Science and Technology Department of Zhejiang Province [2012C24016]
出版者	LIPPINCOTT WILLIAMS & WILKINS
出版地	PHILADELPHIA
ISSN	0025-7974
EISSN	1536-5964
卷号	95 期号:49 页码:e5546.
DOI	10.1097/MD.0000000000005546
页数	10
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
WOS记录号	WOS:000390040000049
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27930552
PMC记录号	PMC5266024
SCOPUSEID	2-s2.0-85007489188
通讯作者地址	[Wang, Xiaochen]Department of Oncology,Cancer Institute,Key Laboratory of Cancer Prevention and Intervention,National Ministry of Education,Provincial Key Laboratory of Molecular Biology in Medical Sciences,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou, Zhejiang,China
Scopus学科分类	Medicine (all)
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/9731
专题	第一临床医学院（信息与工程学院）、附属第一医院_外科学_肿瘤外科
通讯作者	Wang, Xiaochen
作者单位	1.Department of Oncology,Cancer Institute,Key Laboratory of Cancer Prevention and Intervention,National Ministry of Education,Provincial Key Laboratory of Molecular Biology in Medical Sciences,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou, Zhejiang,China; 2.Division of Hematopoietic Stem Cell and Leukemia Research,Beckman Research Institute,City of Hope National Medical Center,Duarte,United States; 3.Department of Plastic Surgery,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China; 4.Department of Surgical Oncology,Third Affiliate Hospital of Wenzhou Medical University,Wenzhou,China; 5.Department of Reproductive,Integrated Chinese and Western Medicine Hospital of Zhejiang Province,Hangzhou,China
推荐引用方式 GB/T 7714	Zhang, Shizhen,Wang, Zhen,Shan, Jinlan,et al. Nuclear expression and/or reduced membranous expression of beta-catenin correlate with poor prognosis in colorectal carcinoma A meta-analysis[J]. MEDICINE,2016,95(49):e5546..
APA	Zhang, Shizhen., Wang, Zhen., Shan, Jinlan., Yu, Xiuyan., Li, Ling., ... & Wang, Xiaochen. (2016). Nuclear expression and/or reduced membranous expression of beta-catenin correlate with poor prognosis in colorectal carcinoma A meta-analysis. MEDICINE, 95(49), e5546..
MLA	Zhang, Shizhen,et al."Nuclear expression and/or reduced membranous expression of beta-catenin correlate with poor prognosis in colorectal carcinoma A meta-analysis".MEDICINE 95.49(2016):e5546..