题名 | Characterisation of endogenous players in fibroblast growth factor-regulated functions of hypothalamic tanycytes and energy-balance nuclei |
作者 | |
发表日期 | 2019-08 |
发表期刊 | JOURNAL OF NEUROENDOCRINOLOGY 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | FGF functions in the hypothalamus gene expression tanycytes |
其他关键词 | COMPREHENSIVE EXPRESSION ATLAS ; MESSENGER-RNA ; BRAIN ; PROTEIN ; ROLES ; MOUSE ; FGF21 ; AXIS ; NEUROGENESIS ; METABOLISM |
摘要 | The mammalian hypothalamus regulates key homeostatic and neuroendocrine functions ranging from circadian rhythm and energy balance to growth and reproductive cycles via the hypothalamic-pituitary and hypothalamic-thyroid axes. In addition to its neurones, tanycytes are taking centre stage in the short- and long-term augmentation and integration of diverse hypothalamic functions, although the genetic regulators and mediators of their involvement are poorly understood. Exogenous interventions have implicated fibroblast growth factor (FGF) signalling, although the focal point of the action of FGF and any role for putative endogenous players also remains elusive. We carried out a comprehensive high-resolution screen of FGF signalling pathway mediators and modifiers using a combination of in situ hybridisation, immunolabelling and transgenic reporter mice, aiming to map their spatial distribution in the adult hypothalamus. Our findings suggest that beta-tanycytes are the likely focal point of exogenous and endogenous action of FGF in the third ventricular wall, utilising FGF receptor (FGFR)1 and FGFR2 IIIc isoforms, but not FGFR3. Key IIIc-activating endogenous ligands include FGF1, 2, 9 and 18, which are expressed by a subset of ependymal and parenchymal cells. In the parenchymal compartment, FGFR1-3 show divergent patterns, with FGFR1 being predominant in neuronal nuclei and expression of FGFR3 being associated with glial cell function. Intracrine FGFs are also present, suggestive of multiple modes of FGF function. Our findings provide a testable framework for understanding the complex role of FGFs with respect to regulating the metabolic endocrine and neurogenic functions of hypothalamus in vivo. |
资助项目 | BBSRC Doctoral Training Programme (DTP) StudentshipUK Research & Innovation (UKRI)Biotechnology and Biological Sciences Research Council (BBSRC); BBSRC research grantUK Research & Innovation (UKRI)Biotechnology and Biological Sciences Research Council (BBSRC) [BB/L003406/1]; EXC2026 [390649896]; NATIONAL HEART, LUNG, AND BLOOD INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [R01HL111190] Funding Source: NIH RePORTER; BBSRCUK Research & Innovation (UKRI)Biotechnology and Biological Sciences Research Council (BBSRC) [BB/L003406/1] Funding Source: UKRI |
出版者 | WILEY |
出版地 | HOBOKEN |
ISSN | 0953-8194 |
EISSN | 1365-2826 |
卷号 | 31期号:8页码:e12750. |
DOI | 10.1111/jne.12750 |
页数 | 12 |
WOS类目 | Endocrinology & Metabolism ; Neurosciences |
WOS研究方向 | Endocrinology & Metabolism ; Neurosciences & Neurology |
WOS记录号 | WOS:000483597000001 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
Pubmed记录号 | 31111569 |
PMC记录号 | PMC6772024 |
Scopus记录号 | 2-s2.0-85069931058 |
通讯作者地址 | [Hajihosseini, Mohammad K.]School of Biological Sciences,University of East Anglia,Norwich,United Kingdom |
scopus学科分类 | Endocrinology, Diabetes and Metabolism;Endocrinology;Endocrine and Autonomic Systems;Cellular and Molecular Neuroscience |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/9719 |
专题 | 卓越中心_国际生长因子研究院 |
通讯作者 | Hajihosseini, Mohammad K. |
作者单位 | 1.School of Biological Sciences,University of East Anglia,Norwich,United Kingdom; 2.Department of Developmental Biology,Washington University School of Medicine,St Louis,United States; 3.Cardio-Pulmonary Institute,Justus Liebig University,Giessen,Germany; 4.International Collaborative Centre on Growth Factor Research,Life Science Institute,Wenzhou Medical University,Wenzhou,China |
推荐引用方式 GB/T 7714 | Kaminskas, Benediktas,Goodman, Timothy,Hagan, Andrew,et al. Characterisation of endogenous players in fibroblast growth factor-regulated functions of hypothalamic tanycytes and energy-balance nuclei[J]. JOURNAL OF NEUROENDOCRINOLOGY,2019,31(8):e12750.. |
APA | Kaminskas, Benediktas, Goodman, Timothy, Hagan, Andrew, Bellusci, Saverio, Ornitz, David M., & Hajihosseini, Mohammad K.. (2019). Characterisation of endogenous players in fibroblast growth factor-regulated functions of hypothalamic tanycytes and energy-balance nuclei. JOURNAL OF NEUROENDOCRINOLOGY, 31(8), e12750.. |
MLA | Kaminskas, Benediktas,et al."Characterisation of endogenous players in fibroblast growth factor-regulated functions of hypothalamic tanycytes and energy-balance nuclei".JOURNAL OF NEUROENDOCRINOLOGY 31.8(2019):e12750.. |
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