Exogenous Basic Fibroblast Growth Factor Inhibits ER Stress-Induced Apoptosis and Improves Recovery from Spinal Cord Injury

doi:10.1111/cns.12013

科研成果详情

题名	Exogenous Basic Fibroblast Growth Factor Inhibits ER Stress-Induced Apoptosis and Improves Recovery from Spinal Cord Injury
作者	Zhang, Hong-Yu1; Zhang, Xie 2; Wang, Zhou-Guang 1,3; Shi, Hong-Xue1; Wu, Fen-Zan 1; Lin, Bei-Bei 1; Xu, Xin-Long3; Wang, Xiao-Jie 1; Fu, Xiao-Bing 4; Li, Zhao-Yu1; Shen, Chen-Jie 1; Li, Xiao-Kun1,5; Xiao, Jian 1
发表日期	2013-01
发表期刊	CNS NEUROSCIENCE & THERAPEUTICS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Apoptosis bFGF ER stress ERK1 2 PI3K Akt Spinal cord injury
其他关键词	ENDOPLASMIC-RETICULUM STRESS ; UNFOLDED PROTEIN RESPONSE ; MESENCHYMAL STEM-CELLS ; FUNCTIONAL RECOVERY ; NEUROTROPHIC FACTOR ; SIGNALING PATHWAY ; OXIDATIVE STRESS ; ACTIVATION ; INFLAMMATION ; BDNF
摘要	Aim To investigate the mechanism of endoplasmic reticulum (ER) stressinduced apoptosis as well as the protective action of basic fibroblast growth factor (bFGF) both in vivo and in vitro. Methods and Results ER stressinduced apoptosis was involved in the injuries of spinal cord injury (SCI) model rat. bFGF administration improved the recovery and increased the survival of neurons in spinal cord lesions in model rat. The protective effect of bFGF is related to the inhibition of CHOP, GRP78 and caspase-12, which are ER stressinduced apoptosis response proteins. bFGF administration also increased the survival of neurons and the expression of growth-associated protein 43 (GAP43), which is related to neural regeneration. The protective effect of bFGF is related to the activation of downstream signals, PI3K/Akt/GSK-3 beta and ERK1/2, especially in the ER stress cell model. Conclusions This is the first study to illustrate that the role of bFGF in SCI recovery is related to the inhibition of ER stressinduced cell death via the activation of downstream signals. Our work also suggested a new trend for bFGF drug development in central neural system injuries, which are involved in chronic ER stressinduced apoptosis.
资助项目	Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents; National Natural Science Funding of ChinaNational Natural Science Foundation of China (NSFC) [81200958]; State Key Basic Research Development Program [2012CB518105]; Zhejiang Provincial Project of Key Group [2010R50042-02]; Zhejiang Provincial Natural Science FoundationNatural Science Foundation of Zhejiang Province [R2090550]; Wenzhou Medical College Research Foundation [QTJ11013]
出版者	WILEY
出版地	HOBOKEN
ISSN	1755-5930
EISSN	1755-5949
卷号	19 期号:1 页码:20-29
DOI	10.1111/cns.12013
页数	10
WOS类目	Neurosciences ; Pharmacology & Pharmacy
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy
WOS记录号	WOS:000312545000004
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	23082997
PMC记录号	PMC6493620
SCOPUSEID	2-s2.0-84871394941
通讯作者地址	[Li, Xiao-Kun]School of Pharmacy,Wenzhou Medical College,China
Scopus学科分类	Pharmacology;Psychiatry and Mental Health;Physiology (medical);Pharmacology (medical)
引用统计	被引频次：98[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/9667
专题	药学院（分析测试中心）其他_附属慈溪医院（慈溪市人民医院）
通讯作者	Li, Xiao-Kun
作者单位	1.School of Pharmacy,Key Laboratory of Biotechnology and Pharmaceutical Engineering,Wenzhou Medical College,China; 2.Ningbo Medical Treatment Center Li Huili Hospital,China; 3.Department of Neurosurgery,Cixi Hospital,Wenzhou Medical College,China; 4.Institute of Basic Medical Science,Chinese PLA General Hospital,China; 5.Engineering Research Center of Bioreactor and Pharmaceutical Development,Ministry of Education,Jilin Agricultural University,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Zhang, Hong-Yu,Zhang, Xie,Wang, Zhou-Guang,et al. Exogenous Basic Fibroblast Growth Factor Inhibits ER Stress-Induced Apoptosis and Improves Recovery from Spinal Cord Injury[J]. CNS NEUROSCIENCE & THERAPEUTICS,2013,19(1):20-29.
APA	Zhang, Hong-Yu., Zhang, Xie., Wang, Zhou-Guang., Shi, Hong-Xue., Wu, Fen-Zan., ... & Xiao, Jian. (2013). Exogenous Basic Fibroblast Growth Factor Inhibits ER Stress-Induced Apoptosis and Improves Recovery from Spinal Cord Injury. CNS NEUROSCIENCE & THERAPEUTICS, 19(1), 20-29.
MLA	Zhang, Hong-Yu,et al."Exogenous Basic Fibroblast Growth Factor Inhibits ER Stress-Induced Apoptosis and Improves Recovery from Spinal Cord Injury".CNS NEUROSCIENCE & THERAPEUTICS 19.1(2013):20-29.