EARLY-LIFE EXPOSURE TO LIPOPOLYSACCHARIDE REDUCES THE SEVERITY OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN ADULTHOOD AND CORRELATED WITH INCREASED URINE CORTICOSTERONE AND APOPTOTIC CD4(+) T CELLS

doi:10.1016/j.neuroscience.2011.07.047

科研成果详情

题名	EARLY-LIFE EXPOSURE TO LIPOPOLYSACCHARIDE REDUCES THE SEVERITY OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN ADULTHOOD AND CORRELATED WITH INCREASED URINE CORTICOSTERONE AND APOPTOTIC CD4(+) T CELLS
作者	Wang, Z. -W.2,3,4; Wang, P.2,3; Lin, F. -H.2,3; Li, X. -L.2,3; Li, X. -F.5; O'Byrne, K. Thomas 5; Hou, S. -T.1,2,3; Zheng, R. -Y.2,3
发表日期	2011-10-13
发表期刊	NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	experimental autoimmune encephalomyelitis multiple sclerosis neuroprotection lipopolysaccharide corticosterone immune regulation
其他关键词	CENTRAL-NERVOUS-SYSTEM ; MULTIPLE-SCLEROSIS ; STRESS ; ALTERS ; RATS ; GLUCOCORTICOIDS ; IMMUNIZATION ; RESPONSIVITY ; INFLAMMATION ; DISEASE
摘要	Early-life exposure to bacterial endotoxins, such as lipopolysaccharides (LPS), can provide neuroprotection against experimental autoimmune encephalomyelitis (EAE) during adulthood, possibly through altering the responsiveness of the immune system. Here, we show that exposure of LPS to neonatal rats resulted in a sustained elevation of corticosterone level in urine when compared with saline-treated rats, and that the high level of urine corticosterone was maintained during the progression of EAE (P<0.05). This high level of production of corticosterone plays an important role in altering the predisposition to EAE-induced neuroinflammation, as a positive correlation occurred between the concentration of urine corticosterone and the increased apoptotic CD4(+) T cells from the peripheral blood. LPS-treated rats also showed a reduced number of CD3(+) T cells in the spinal cord. The splenic antigen-presenting cells showed a reduced expression of MHC II during EAE development in LPS-exposed rats when compared with rats exposed to the saline-treated control. Together, these findings suggest that treating neonatal rats with LPS evokes a sustained elevation of glucocorticoid, which may suppress immune response during EAE by increasing apoptosis of CD4(+) T cells and reducing the expression of MHC II on antigen-presenting cells. Therefore, exposing neonates to bacterial endotoxin may further be developed as an immunization strategy to prevent human multiple sclerosis and other inflammatory brain diseases. Crown Copyright (C) 2011 Published by Elsevier Ltd on behalf of IBRO. All rights reserved.
资助项目	Wenzhou Medical College [XNK07001, 3010]; Zhejiang Key Subjects (Pharmacology and Biochemical Pharmaceutics) [Y2100960]; BBSRCUK Research & Innovation (UKRI)Biotechnology and Biological Sciences Research Council (BBSRC) [BB/F007396/1] Funding Source: UKRI; Biotechnology and Biological Sciences Research CouncilUK Research & Innovation (UKRI)Biotechnology and Biological Sciences Research Council (BBSRC) [BB/F007396/1] Funding Source: researchfish
出版者	PERGAMON-ELSEVIER SCIENCE LTD
出版地	OXFORD
ISSN	0306-4522
EISSN	1873-7544
卷号	193 页码:283-290
DOI	10.1016/j.neuroscience.2011.07.047
页数	8
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000295189200028
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	21807067
SCOPUSEID	2-s2.0-80052461664
通讯作者地址	[Hou, S. -T.]Natl Res Council Canada, Inst Biol Sci, 1200 Montreal Rd,Bldg M54, Ottawa, ON K1A 0R6, Canada.
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/9606
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科药学院（分析测试中心）_实验神经生物研究所
通讯作者	Hou, S. -T.
作者单位	1.Natl Res Council Canada, Inst Biol Sci, Ottawa, ON K1A 0R6, Canada; 2.Wenzhou Med Coll, Affiliated Hosp 1, Dept Neurol, Wenzhou City 325000, Zhejing Provinc, Peoples R China; 3.Wenzhou Med Coll, Res Inst Expt Neurobiol, Wenzhou City 325000, Zhejing Provinc, Peoples R China; 4.Shaoxing Peoples Hosp, Dept Neurol, Shaoxing City 312000, Zhejiang, Peoples R China; 5.Kings Coll London, Div Reprod & Endocrinol, London SE1 1UL, England
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科; 药学院（分析测试中心）_实验神经生物研究所
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
推荐引用方式 GB/T 7714	Wang, Z. -W.,Wang, P.,Lin, F. -H.,et al. EARLY-LIFE EXPOSURE TO LIPOPOLYSACCHARIDE REDUCES THE SEVERITY OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN ADULTHOOD AND CORRELATED WITH INCREASED URINE CORTICOSTERONE AND APOPTOTIC CD4(+) T CELLS[J]. NEUROSCIENCE,2011,193:283-290.
APA	Wang, Z. -W.., Wang, P.., Lin, F. -H.., Li, X. -L.., Li, X. -F.., ... & Zheng, R. -Y.. (2011). EARLY-LIFE EXPOSURE TO LIPOPOLYSACCHARIDE REDUCES THE SEVERITY OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN ADULTHOOD AND CORRELATED WITH INCREASED URINE CORTICOSTERONE AND APOPTOTIC CD4(+) T CELLS. NEUROSCIENCE, 193, 283-290.
MLA	Wang, Z. -W.,et al."EARLY-LIFE EXPOSURE TO LIPOPOLYSACCHARIDE REDUCES THE SEVERITY OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN ADULTHOOD AND CORRELATED WITH INCREASED URINE CORTICOSTERONE AND APOPTOTIC CD4(+) T CELLS".NEUROSCIENCE 193(2011):283-290.