KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation

doi:10.1002/cam4.2226

科研成果详情

题名	KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation
作者	Fang, Yang 1,2; Zhang, Dan3; Hu, Tingting4; Zhao, Hongyan1,2; Zhao, Xuan 1,2; Lou, Zhefeng1,2; He, Yongshan 5; Qin, Wenzheng 6; Xia, Jianfu 7; Zhang, Xiaohua 8; Ye, Le-chi8
发表日期	2019-07
发表期刊	CANCER MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	cancer development CTSZ epigenetic modifier KMT2A
摘要	Accumulating evidence supports the notion that epigenetic modifiers are abnormal in carcinogenesis and have a fundamental role in cancer progression. Among these aberrant epigenetic modifiers, the function of histone methyltransferase KMT2A in somatic tumors is not well known. By analyzing KMT2A expression in patient tissues, we demonstrated that KMT2A was overexpressed in colorectal cancer tissues in comparison with adjacent normal tissues and its expression was positively correlated with cancer stages. In KMT2A-knockdown HCT116 and DLD1 cells, cell invasion and migration were consequently suppressed. In addition, KMT2A depletion effectively suppressed cancer metastasis in vivo. Mechanistically, cathepsin Z (CTSZ) was demonstrated to be an important downstream gene of KMT2A. Further studies showed that p65 could recruit KMT2A on the promoter region of the downstream gene CTSZ and knockdown of p65 could reduce the KMT2A on the promoter of CTSZ. Finally, our present study revealed that KMT2A epigenetically promotes cancer progression by targeting CTSZ, which has specific functions in cancer invasion and metastasis.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81572291]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY15H160058]; Shanghai Committee of Science and TechnologyShanghai Science & Technology Committee [17ZR1405500]; Zhejiang Provincial Medical technology science project [2015KYB245]
出版者	WILEY
出版地	HOBOKEN
ISSN	2045-7634
卷号	8 期号:7 页码:3544-3552
DOI	10.1002/cam4.2226
页数	9
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000477017100022
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	31090199
PMC记录号	PMC6601586
SCOPUSEID	2-s2.0-85068425676
通讯作者地址	[Zhang, Xiaohua]Department of Colorectal and Anal Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Oncology;Radiology, Nuclear Medicine and Imaging;Cancer Research
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/9594
专题	检验医学院（生命科学学院、生物学实验教学中心）附属第一医院_肝胆外科附属第一医院_呼吸内科附属第一医院_肛肠外科
通讯作者	Zhang, Xiaohua
作者单位	1.Zhejiang Provincial Key Laboratory for Technology and Application of Model Organisms,Key Laboratory of Laboratory Medicine,Ministry of Education,Wenzhou,China; 2.School of Laboratory Medicine and Life Sciences,Wenzhou Medical University,Wenzhou,China; 3.Department of Respiratory Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 4.Department of Gastroenterology and Hepatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 5.Department of Colorectal and Anal Surgery,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China; 6.Endoscopy Center,Zhongshan Hospital,Fudan University,Shanghai,China; 7.Department of General Surgery,Wenzhou Central Hospital,Wenzhou,China; 8.Department of Colorectal and Anal Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	检验医学院（生命科学学院、生物学实验教学中心）
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
推荐引用方式 GB/T 7714	Fang, Yang,Zhang, Dan,Hu, Tingting,et al. KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation[J]. CANCER MEDICINE,2019,8(7):3544-3552.
APA	Fang, Yang., Zhang, Dan., Hu, Tingting., Zhao, Hongyan., Zhao, Xuan., ... & Ye, Le-chi. (2019). KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation. CANCER MEDICINE, 8(7), 3544-3552.
MLA	Fang, Yang,et al."KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation".CANCER MEDICINE 8.7(2019):3544-3552.