Association between the GSTP1 Ile105Val polymorphism and prostate cancer risk: a systematic review and meta-analysis

doi:10.1007/s13277-013-0727-x

科研成果详情

题名	Association between the GSTP1 Ile105Val polymorphism and prostate cancer risk: a systematic review and meta-analysis
作者	Yu, Zhuo 1; Li, Zhong 2; Cai, Bing3; Wang, Ziming 4; Gan, Weimin 4; Chen, Haiwen 4; Li, Hecheng 4; Zhang, Peng 4; Li, Hongliang 4
发表日期	2013-06
发表期刊	TUMOR BIOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	GSTP1 polymorphisms Ile105Val Prostate cancer Meta-analysis
其他关键词	GLUTATHIONE-S-TRANSFERASE ; GENE POLYMORPHISMS ; OXIDATIVE STRESS ; P1 POLYMORPHISMS ; GSTT1 ; GSTM1 ; SUSCEPTIBILITY ; M1 ; T1 ; STATISTICS
摘要	Many studies have reported the role of glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism with prostate cancer (PCa) risk. However, these studies have yielded conflicting results. Hence, we performed this meta-analysis to investigate the association between GSTP1 Ile105Val polymorphism and PCa in different inheritance models. A total of 13 eligible studies were pooled into this meta-analysis. There was significant association between the GSTP1 Ile158Val variant genotypes and PCa for Ile/Ile vs Val/Val comparison [odds ratio (OR) = 0.705; I (2) = 63.7 %; 95 % confidence interval (95 % CI) = 0.508-0.977], Ile/Val vs Val/Val comparison (OR = 0.736; I (2) = 8.0 %; 95 % CI = 0.613-0.883), and dominant model (OR = 0.712; I (2) = 45.5 %; 95 % CI = 0.555-0.913). However, no associations were detected for other genetic models. In the stratified analysis by ethnicity, significant associations between GSTP1 Ile105Val polymorphism and PCa risk were also found among Caucasians (Ile/Ile vs Val/Val comparison OR = 0.818, I (2) = 0.0 %, 95 % CI = 0.681-0.982; Ile/Val vs Val/Val comparison OR = 0.779, I (2) = 0.0 %, 95 % CI = 0.651-0.933; and dominant model OR = 0.794, I (2) = 0.0 %, 95 % CI = 0.670-0.941), while there were no associations found for other genetic models. However, no associations were found in Asians and African-Americans for all genetic models when stratified by ethnicity. In conclusion, our meta-analysis indicates that GSTP1 Ile105Val polymorphisms contributed to the PCa susceptibility. However, a study with the larger sample size is needed to further evaluate gene-environment interaction on GSTP1 Ile105Val polymorphisms and PCa risk.
出版者	SAGE PUBLICATIONS LTD
出版地	LONDON
ISSN	1010-4283
EISSN	1423-0380
卷号	34 期号:3 页码:1855-1863
DOI	10.1007/s13277-013-0727-x
页数	9
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000319356900067
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	23494181
SCOPUSEID	2-s2.0-84878732465
通讯作者地址	[Cai, Bing]Department of Urology,First Affiliated Hospital of Wenzhou Medical College,China
Scopus学科分类	Cancer Research
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/9542
专题	第一临床医学院（信息与工程学院）、附属第一医院_外科学_泌尿外科附属第一医院
通讯作者	Cai, Bing
作者单位	1.Department of Medical Oncology,Second Affiliated Hospital,Zhejiang University School of Medicine,China; 2.Department of Urology,Second Hospital of Tianjin Medical University,Tianjin Institute of Urology,China; 3.Department of Urology,First Affiliated Hospital of Wenzhou Medical College,China; 4.Department of Urology,Second Affiliated Hospital,Xi'An Jiaotong University,China
通讯作者单位	附属第一医院
推荐引用方式 GB/T 7714	Yu, Zhuo,Li, Zhong,Cai, Bing,et al. Association between the GSTP1 Ile105Val polymorphism and prostate cancer risk: a systematic review and meta-analysis[J]. TUMOR BIOLOGY,2013,34(3):1855-1863.
APA	Yu, Zhuo., Li, Zhong., Cai, Bing., Wang, Ziming., Gan, Weimin., ... & Li, Hongliang. (2013). Association between the GSTP1 Ile105Val polymorphism and prostate cancer risk: a systematic review and meta-analysis. TUMOR BIOLOGY, 34(3), 1855-1863.
MLA	Yu, Zhuo,et al."Association between the GSTP1 Ile105Val polymorphism and prostate cancer risk: a systematic review and meta-analysis".TUMOR BIOLOGY 34.3(2013):1855-1863.