ALDH1-positive cancer stem-like cells are enriched in nodal metastases of oropharyngeal squamous cell carcinoma independent of HPV status

doi:10.3892/or.2013.2340

科研成果详情

题名	ALDH1-positive cancer stem-like cells are enriched in nodal metastases of oropharyngeal squamous cell carcinoma independent of HPV status
作者	Qian, Xu1,2; Wagner, Steffen 3; Ma, Chenming 1; Klussmann, Jens P.3; Hummel, Michael 4; Kaufmann, Andreas M.5; Albers, Andreas E.1
发表日期	2013-05
发表期刊	ONCOLOGY REPORTS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	squamous cell carcinoma human papillomavirus cancer stem cell aldehyde-dehydrogenase metastasis
其他关键词	HUMAN-PAPILLOMAVIRUS ; NECK ; HEAD ; SUBPOPULATION ; DNA
摘要	Oropharyngeal squamous cell carcinoma (OSCC) is caused by high-risk (HR) human papillomavirus (HPV) or alcohol and tobacco abuse. Aldehyde dehydrogenase 1 (ALDH1) is a confirmed marker for cancer stem-like cells (CSCs) of OSCC responsible for therapy resistance, recurrence and metastasis. Associations between HR-HPV/p16, CSC frequency and clinicopathological parameters in patients with metastatic OSCC were investigated. In the present study, HPV genotypes and expression of ALDH1 and p16 was analyzed in 40 paired OSCC and metastases. A significant correlation between ALDH1 positivity with lower primary tumor differentiation grade (P=0.009) and higher nodal status (P=0.015) was noted. Compared to primary tumors, the proportion of ALDH1-expressing cells was significantly increased in metastases (P=0.012), while significantly fewer ALDH1-expressing cells were found in HR-HPV-DNA(+)/p16(+) primary tumors (P=0.038) compared to HR-HPV-DNA(-)/p16(-) primary tumors. Metastases showed no difference. ALDH1(+) CSCs are detectable in OSCC and metastases. ALDH1 high-grade OSCC exhibits a more aggressive phenotype characterized by higher nodal classification and lower differentiation. This suggests a subpopulation contained in the ALDH1-positive OSCC cell pool able to complete the metastatic cascade and subsequently enriching in metastasis independent of tumor etiology and ALDH1 content.
资助项目	ZAST-organization
出版者	SPANDIDOS PUBL LTD
出版地	ATHENS
ISSN	1021-335X
EISSN	1791-2431
卷号	29 期号:5 页码:1777-1784
DOI	10.3892/or.2013.2340
页数	8
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000317542900015
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	23483187
SCOPUSEID	2-s2.0-84876239864
通讯作者地址	[Albers, Andreas E.]Department of Otorhinolaryngology, Head and Neck Surgery,Charité-Universitätsmedizin Berlin,Campus Benjamin Franklin,Hindenburgdamm 30,Germany
Scopus学科分类	Oncology;Cancer Research
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/9513
专题	基础医学院（机能实验教学中心）_形态学系_组织胚胎学
通讯作者	Albers, Andreas E.
作者单位	1.Department of Otorhinolaryngology, Head and Neck Surgery,Charité-Universitätsmedizin Berlin,Campus Benjamin Franklin,Hindenburgdamm 30,Germany; 2.Zhejiang Provincial Key Laboratory of Medical Genetics,Department of Histology and Embryology,Wenzhou Medical College,China; 3.University Hospital of Giessen and Marburg,Department of Otorhinolaryngology, Head and Neck Surgery,Germany; 4.Institute of Pathology,Charité-Universitätsmedizin Berlin,Campus Benjamin Franklin,Germany; 5.Clinic for Gynecology,Charité-Universitätsmedizin Berlin,Campus Mitte and Benjamin Franklin,Germany
第一作者单位	组织胚胎学
推荐引用方式 GB/T 7714	Qian, Xu,Wagner, Steffen,Ma, Chenming,et al. ALDH1-positive cancer stem-like cells are enriched in nodal metastases of oropharyngeal squamous cell carcinoma independent of HPV status[J]. ONCOLOGY REPORTS,2013,29(5):1777-1784.
APA	Qian, Xu., Wagner, Steffen., Ma, Chenming., Klussmann, Jens P.., Hummel, Michael., ... & Albers, Andreas E.. (2013). ALDH1-positive cancer stem-like cells are enriched in nodal metastases of oropharyngeal squamous cell carcinoma independent of HPV status. ONCOLOGY REPORTS, 29(5), 1777-1784.
MLA	Qian, Xu,et al."ALDH1-positive cancer stem-like cells are enriched in nodal metastases of oropharyngeal squamous cell carcinoma independent of HPV status".ONCOLOGY REPORTS 29.5(2013):1777-1784.