Expression of connective tissue growth factor and periostin of wound tissue in patients with diabetes who had vacuum sealing drainage

科研成果详情

题名	Expression of connective tissue growth factor and periostin of wound tissue in patients with diabetes who had vacuum sealing drainage
作者	Zhang, Xingxing 1,8; Wan, Li2; Yang, Ruijin 7; Jin, Pengpeng 4; Xia, Weidong3; Ye, Yuanyuan3; Liu, Zhengjun3; Xian, Jian 5; Li, Xu 6; Cheng, Xingbo 1; Lin, Cai3
发表日期	2017-12-31
发表期刊	INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Diabetic ulcer connective tissue growth factor periostin vacuum sealing drainage
其他关键词	ASSISTED CLOSURE ; CCN2 EXPRESSION
摘要	This study aimed to examine clinical effect of vacuum sealing drainage in treating the wound tissue of patients with diabetes; and investigate the expression of periostin and connective tissue growth factor in wound tissue. We selected 40 patients with diabetes and chronic ulcers, and assigned randomly into two groups: the vacuum sealing drainage group and routine dressing group (controls). Tissues were cut at day 1 before treatment and day 7 after treatment. Immunohistochemistry was used to observe periostin and connective tissue growth factor expression. Cure time and cure rate between the two groups was observed. Connective tissue growth factor and periostin were rarely expressed in wound tissue before treatment, but were increased after treatment. The mean count of periostin-positive cells was 25.2 +/- 3.50 in the vacuum sealing drainage group and 12.9 +/- 1.8 in the control group (P < 0.05). The mean count of connective tissue growth factor-positive cells was 19.7 +/- 2.54 in the vacuum sealing drainage group and 6.8 +/- 1.58 in the control group (P < 0.05). The mean duration of hospitalization of the vacuum sealing drainage group was 33.4 +/- 7.91 days, and 17 (85%) patients were cured. The mean duration of hospitalization of the routine treatment group was 50.45 +/- 6.77 days, and 13 (65%) patients were cured (both P < 0.05). This study shows that vacuum sealing drainage can shorten the healing time of diabetic chronic wounds and was addition to the mechanism of the vacuum sealing drainage treatment of diabetic wound.
资助项目	Action Planning for Major disease prevention science and technology of Development Center for Medical Science and Technology National Health and Family Planning Commission of the People's Republic of China [ZX-01-C2015041]; Science and Technology Program of Wenzhou [Y20150273, Y20130166, Y20140-187]; Education Department of Zhejiang Province [Y201431185]
出版者	E-CENTURY PUBLISHING CORP
出版地	MADISON
ISSN	1940-5901
卷号	10 期号:8 页码:12942-12950
页数	9
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
WOS记录号	WOS:000427722200001
收录类别	SCIE ; SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-85030654275
通讯作者地址	[Cheng, Xingbo]Department of Endocrinology,The First Affiliated Hospital of Soochow University,Suzhou,215006,China
Scopus学科分类	Biochemistry, Genetics and Molecular Biology (all)
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/9473
专题	附属第一医院仁济学院药学院（分析测试中心）_生物制药系_生物制药工程
通讯作者	Cheng, Xingbo
作者单位	1.Department of Endocrinology,The First Affiliated Hospital of Soochow University,Suzhou,215006,China; 2.Department of Pathology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Department of Burn and Wound Healing Centre,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 4.Centre for Medical Research and Innovation,Shanghai Pudong Hospital,Fudan University Pudong Medical Center,2800 Gongwei Road,Shanghai,201399,China; 5.School of Pharmacy,Key Laboratory of Biotechnology and Pharmaceutical Engineering,Wenzhou Medical University,Wenzhou,325000,China; 6.Department of Physiology,Renji College,Wenzhou Medical University,Wenzhou,325000,China; 7.Department of Burns and Plastic Surgery,Tung Wah Hospital Afflicted to Sun Yat-sen University,Dongguan,523000,China; 8.Department of Endocrinology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
推荐引用方式 GB/T 7714	Zhang, Xingxing,Wan, Li,Yang, Ruijin,et al. Expression of connective tissue growth factor and periostin of wound tissue in patients with diabetes who had vacuum sealing drainage[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2017,10(8):12942-12950.
APA	Zhang, Xingxing., Wan, Li., Yang, Ruijin., Jin, Pengpeng., Xia, Weidong., ... & Lin, Cai. (2017). Expression of connective tissue growth factor and periostin of wound tissue in patients with diabetes who had vacuum sealing drainage. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 10(8), 12942-12950.
MLA	Zhang, Xingxing,et al."Expression of connective tissue growth factor and periostin of wound tissue in patients with diabetes who had vacuum sealing drainage".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 10.8(2017):12942-12950.