Reversal of Early Diabetic Nephropathy by Islet Transplantation under the Kidney Capsule in a Rat Model

doi:10.1155/2016/4157313

科研成果详情

题名	Reversal of Early Diabetic Nephropathy by Islet Transplantation under the Kidney Capsule in a Rat Model
作者	He, Yunqiang 1; Xu, Ziqiang2; Zhou, Mingshi 1; Wu, Minmin1; Chen, Xuehai1; Wang, Silu1; Qiu, Kaiyan 3; Cai, Yong2; Fu, Hongxing3; Chen, Bicheng1; Zhou, Mengtao4
发表日期	2016-12-31
发表期刊	JOURNAL OF DIABETES RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	C-PEPTIDE ; TGF-BETA ; PANCREAS ; GLOMERULOSCLEROSIS ; COMPLICATIONS ; HYPOGLYCEMIA ; PROMOTES ; GLUCOSE ; INJURY ; RISK
摘要	Objective. Diabetic nephropathy (DN) is a common microvascular complication of diabetes mellitus, and insulin therapy has many side effects in the treatment of DN. Islet transplantation has emerged as a promising therapy for diabetic patients. This study was established to investigate its advantageous effects in a rat model of early DN. Methods. Streptozotocin was administered to the rats to induce diabetes. Twelve weeks later, the diabetic rats were divided into 3 groups: the islet-transplanted group (IT group), the insulin-treated group (IN group), and the untreated group (DN group). Renal injury and kidney structure were assessed by urinalysis and transmission electron microscopy (TEM) detection. Immunohistochemical staining and western blotting were performed to assess renal fibrosis levels. Results. The early DN features were reversed and the glomerular filtration barrier and basement membrane structures were improved at 4 weeks after islet transplantation. The urine microalbumin-to-creatinine ratio (ACR), protein-to-creatinine ratio, and mean thickness of the glomerular basement membrane (GBM) were significantly decreased in the IT group. The expression of renal fibrotic factors was also significantly decreased. Conclusions. These data suggest that early DN can be reversed after islet transplantation, and they may facilitate the development of a clinical therapeutic strategy for human diabetes mellitus.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81572087]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY12H05004, Y14H050028]; Science Technology Department of Zhejiang Province [2013C37006]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	2314-6745
EISSN	2314-6753
卷号	2016 页码:4157313
DOI	10.1155/2016/4157313
页数	12
WOS类目	Endocrinology & Metabolism ; Medicine, Research & Experimental
WOS研究方向	Endocrinology & Metabolism ; Research & Experimental Medicine
WOS记录号	WOS:000385108900001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27725943
PMC记录号	PMC5048050
SCOPUSEID	2-s2.0-84990984015
通讯作者地址	[Chen, Bicheng]Key Laboratory of Surgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism;Endocrinology
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/942
专题	附属第一医院_移植科药学院（分析测试中心）第一临床医学院（信息与工程学院）、附属第一医院
通讯作者	Chen, Bicheng
作者单位	1.Key Laboratory of Surgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Transplantation,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,325000,China; 3.School of Pharmacy,Wenzhou Medical University,Wenzhou, Zhejiang Province,325000,China; 4.Department of Surgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	He, Yunqiang,Xu, Ziqiang,Zhou, Mingshi,et al. Reversal of Early Diabetic Nephropathy by Islet Transplantation under the Kidney Capsule in a Rat Model[J]. JOURNAL OF DIABETES RESEARCH,2016,2016:4157313.
APA	He, Yunqiang., Xu, Ziqiang., Zhou, Mingshi., Wu, Minmin., Chen, Xuehai., ... & Zhou, Mengtao. (2016). Reversal of Early Diabetic Nephropathy by Islet Transplantation under the Kidney Capsule in a Rat Model. JOURNAL OF DIABETES RESEARCH, 2016, 4157313.
MLA	He, Yunqiang,et al."Reversal of Early Diabetic Nephropathy by Islet Transplantation under the Kidney Capsule in a Rat Model".JOURNAL OF DIABETES RESEARCH 2016(2016):4157313.