Interleukin-4 Ameliorates the Functional Recovery of Intracerebral Hemorrhage Through the Alternative Activation of Microglia/Macrophage

doi:10.3389/fnins.2016.00061

科研成果详情

题名	Interleukin-4 Ameliorates the Functional Recovery of Intracerebral Hemorrhage Through the Alternative Activation of Microglia/Macrophage
作者	Yang, Jianjing1; Ding, Saidan1; Huang, Weilong 1; Hu, Jiangnan1; Huang, Shengwei 1; Zhang, Yu 1; Zhuge, Qichuan1,2
发表日期	2016-03-08
发表期刊	FRONTIERS IN NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	stroke intracerebral hemorrhage interleukin-4(IL-4) microglia/macrophage recovery M1 phenotype M2 phenotype
其他关键词	TRAUMATIC BRAIN-INJURY ; T-CELLS ; MICROGLIA ; POLARIZATION ; BLOOD ; INHIBITION ; STROKE ; RATS
摘要	Neuro-inflammation plays an important role in the recovery of brain injury after stroke. Microglia/macrophage is the major executor in the neuro-inflammation, which can be polarized into two distinct phenotypes: injurious/toxic classical activation (M1 phenotype) and protective alternative activation (M2 phenotype). Here, we investigated whether intracerebral administration of interleukin-4 (IL-4) at an early stage could affect the activation of microglia/macrophage and the corresponding outcome after intracerebral hemorrhage (ICH). The neuro-behavior was recorded between different groups in the rat ICH model. The M1 and M2 markers were then determined by qRT-PCR, western blotting, ELISA, and immunofluorescence, respectively. We observed aberrant activation of microglia/macrophage after ICH. After intracerebral injection of IL-4, M1 activation was greatly inhibited while M2 activation was enhanced, along with improving neurobehavioral recovery from deficits after ICH. Our study showed that early intracerebral injection of IL-4 potentially promotes neuro-functional recovery, probably through enhancing the alternative activation of microglia/macrophage.
资助项目	QZ's National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81171088, 81371396]; YZ's Natural Science Foundation of Zhejiang Province [Y 2110807]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1662-453X
EISSN	1662-453X
卷号	10 期号:MAR 页码:61
DOI	10.3389/fnins.2016.00061
页数	8
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000371566200001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27013935
PMC记录号	PMC4781843
SCOPUSEID	2-s2.0-84964329436
通讯作者地址	[Zhuge, Qichuan]Department of Neurosurgery,First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Neuroscience (all)
引用统计	被引频次：47[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/936
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_老化与神经疾病重点实验室
通讯作者	Zhuge, Qichuan
作者单位	1.Department of Neurosurgery,First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China; 2.Zhejiang Provincial Key Laboratory of Aging and Neurological Disease,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yang, Jianjing,Ding, Saidan,Huang, Weilong,et al. Interleukin-4 Ameliorates the Functional Recovery of Intracerebral Hemorrhage Through the Alternative Activation of Microglia/Macrophage[J]. FRONTIERS IN NEUROSCIENCE,2016,10(MAR):61.
APA	Yang, Jianjing., Ding, Saidan., Huang, Weilong., Hu, Jiangnan., Huang, Shengwei., ... & Zhuge, Qichuan. (2016). Interleukin-4 Ameliorates the Functional Recovery of Intracerebral Hemorrhage Through the Alternative Activation of Microglia/Macrophage. FRONTIERS IN NEUROSCIENCE, 10(MAR), 61.
MLA	Yang, Jianjing,et al."Interleukin-4 Ameliorates the Functional Recovery of Intracerebral Hemorrhage Through the Alternative Activation of Microglia/Macrophage".FRONTIERS IN NEUROSCIENCE 10.MAR(2016):61.