Association of peripheral anterior synechia, intraocular pressure, and glaucomatous optic neuropathy in primary angle-closure diseases

doi:10.18240/ijo.2021.10.09

科研成果详情

题名	Association of peripheral anterior synechia, intraocular pressure, and glaucomatous optic neuropathy in primary angle-closure diseases
作者	Zhang, Ming 1; Mao, Guang-Yun2,3; Ye, Cong2; Fan, Su-Jie 4; Liang, Yuan-Bo2; Wang, Ning-Li 5
发表日期	2021-10-18
发表期刊	INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	primary angle-closure glaucoma peripheral anterior synechiae intraocular pressure
其他关键词	PHACOEMULSIFICATION ; CLASSIFICATION ; PREVALENCE ; MANAGEMENT ; RISK
摘要	AIM: To investigate the association of peripheral anterior synechiae (PAS) with intraocular pressure (IOP) and glaucomatous optic neuropathy (GON) in primary angle closure (PAC) and primary angle-closure glaucoma (PACG). METHODS: Totally 355 eyes (238 PAC and 117 PACG) of 181 patients were included in this retrospective analysis of baseline data from a randomized clinical trial. All patients had undergone a comprehensive ophthalmic examination. The extent of PAS in clock hours as determined on gonioscopy was documented. The independent effect of the extent of PAS on IOP and the prevalence of GON were determined using multivariable generalized estimating equation (GEE) models. RESULTS: The frequency of GON increased with the extent of PAS and a higher IOP. PAS were more extensive (8 vs 1 clock hour, P<0.001) and IOP higher (28.01 vs 18.00 mm Hg, P<0.001) in PACG compared to PAC. The prevalence of GON among the PAS quartiles were 10.2% (PAS<0.5 clock hours), 16.9% (PAS >= 0.5 and PAS<3 clock hours), 29.6% (PAS >= 3 and PAS<7 clock hours), and 74.4% PAS >= 7 clock hours), respectively. After adjusting for IOP, age, gender, spherical equivalent, average Shaffer score and number of medications, the odds ratio (OR) for GON was 4.4 (95%CI: 1.5-13.0; P=0.007) with PAS >= 3 clock hours and 13.8 (95%CI: 4.3-43.6; P<0.001) with PAS >= 7 clock hours as compared to eyes with PAS<0.5 clock hours. The frequency of GON increased linearly with the extent of PAS. Extent of PAS was also associated with higher IOP. Eyes with both PAS >= 6 clock hours and IOP >= 21 mm Hg had the highest risk of GON compared to eyes with both PAS<6 clock hours and IOP<21 mm Hg (OR=18.0, 95%CI: 7.5-43.4; P<0.001). CONCLUSION: The extent of PAS in PAC and PACG is an important predictor of higher IOP and is linearly associated with GON independent of IOP, suggesting other factors related to PAS formation may be involved in the development of GON in PACG.
资助项目	Health Innovation Talents in Zhejiang Province [2016025]; Wenzhou Medical University RD Fund [QTJ13009]
出版者	IJO PRESS
出版地	XI AN
ISSN	2222-3959
EISSN	2227-4898
卷号	14 期号:10 页码:1533-1538
DOI	10.18240/ijo.2021.10.09
页数	6
WOS类目	Ophthalmology
WOS研究方向	Ophthalmology
WOS记录号	WOS:000703898800009
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	34667729
PMC记录号	PMC8481989
SCOPUSEID	2-s2.0-85115911239
通讯作者地址	[Liang, Yuan-Bo]Clinical and Epidemiological Eye Research Center,Eye Hospital,School of Optometry and Ophthalmology,Wenzhou Medical University,No.270, Xue Yuan Xi Road, Zhejiang Province,Wenzhou,325027,China
Scopus学科分类	Ophthalmology
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/9337
专题	眼视光学院（生物医学工程学院）、附属眼视光医院公共卫生学院眼视光学院（生物医学工程学院）、附属眼视光医院_临床与流行病学研究中心
通讯作者	Liang, Yuan-Bo
作者单位	1.Department of Ophthalmology,ZhongDa Hospital,Southeast University,Jiangsu Province,Nanjing,210009,China; 2.Glaucoma Institute,Eye Hospital,School of Optometry and Ophthalmology,Wenzhou Medical University,Zhejiang Province,Wenzhou,325027,China; 3.Center of Evidence-Based Medicine and Clinical Epidemiological Research,School of Public Health,Wenzhou Medical University,Zhejiang Province,Wenzhou,325035,China; 4.Handan Eye Hospital,Hebei Province,Handan,056001,China; 5.Beijing Tongren Hospital,Beijing Institute of Ophthalmology,Capital Medical University,Beijing,100730,China
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
推荐引用方式 GB/T 7714	Zhang, Ming,Mao, Guang-Yun,Ye, Cong,et al. Association of peripheral anterior synechia, intraocular pressure, and glaucomatous optic neuropathy in primary angle-closure diseases[J]. INTERNATIONAL JOURNAL OF OPHTHALMOLOGY,2021,14(10):1533-1538.
APA	Zhang, Ming, Mao, Guang-Yun, Ye, Cong, Fan, Su-Jie, Liang, Yuan-Bo, & Wang, Ning-Li. (2021). Association of peripheral anterior synechia, intraocular pressure, and glaucomatous optic neuropathy in primary angle-closure diseases. INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, 14(10), 1533-1538.
MLA	Zhang, Ming,et al."Association of peripheral anterior synechia, intraocular pressure, and glaucomatous optic neuropathy in primary angle-closure diseases".INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 14.10(2021):1533-1538.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
GYZZ202110021.caj（575KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载