Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with Sustained Drug Release and NIR-Responsive Photothermal Effect

doi:10.2147/IJN.S248538

科研成果详情

题名	Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with Sustained Drug Release and NIR-Responsive Photothermal Effect
作者	Lin, Jian 1; He, Zhiqi2; Liu, Fen 3; Feng, Jie 4; Huang, Chengyi 5; Sun, Xueli 4; Deng, Hui1
发表日期	2020
发表期刊	INTERNATIONAL JOURNAL OF NANOMEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	periodontitis mesoporous silica Au nanobipyramids gelatin methacrylate photothermal therapy antibacterial properties
其他关键词	MESOPOROUS SILICA NANOPARTICLES ; GOLD NANOBIPYRAMIDS ; BACTERIA ; THERAPY ; PATHOGENS ; DELIVERY
摘要	Background: Periodontal pathogenic bacteria promote the destruction of periodontal tissues and cause loosening and loss of teeth in adults. However, complete removal of periodontal pathogenic bacteria, at both the bottom of the periodontal pocket and the root bifurcation area, remains challenging. In this work, we explored a synergistic antibiotic and photothermal treatment, which is considered an alternative strategy for highly efficient periodontal antibacterial therapy. Methods: Mesoporous silica (MSN5) on the surface of Au nanobipyramids (Au NBPs) were designed to achieve the sustained release of the drug and photothermal antibacterials. The mesoporous silica-coated Au NBPs (Au NBPs@SiO2) were mixed with gelatin methacrylate (Ge1MA-Au NBPs@SiO2). Au NBPs@SiO2 and Ge1MA-Au NBPs@SiO2 hybrid hydrogels were characterized, and the drug content and photothermal properties in terms of the release profile, bacterial inhibition, and cell growth were investigated. Results: The Ge1MA-Au NBPs@SiO2 hybrid hydrogels showed controllable minocycline delivery, and the drug release rates increased under 808 nm near-infrared (NIR) light irradiation. The hydrogels also exhibited excellent antibacterial properties, and the antibacterial efficacy of the antibiotic and photothermal treatment was as high as 90% and 66.7% against Porphyromonas gingivalis (P. gingivalis), respectively. Moreover, regardless of NIR irradiation, cell viability was over 80% and the concentration of Au NBPs@SiO2 in the hybrid hydrogels was as high as 100 ug/mL. Conclusion: We designed a new near-infrared light (NIR)-activated hybrid hydrogel that offers both sustained release of antibacterial drugs and photothermal treatment. Such sustained release pattern yields the potential to rapidly eliminate periodontal pathogens in the periodontal pocket, and the photothermal treatment maintains low bacterial retention after the drug treatment.
资助项目	scientific research fund of the National Health Commission [wkj-zj-1707]; Zhejiang Provincial Science and Technology Project for Public Welfare [LGF20H140003]; Zhejiang Provincial Medical and Health Science and Technology Plan [2019KY444]; Wenzhou basic scientific research project [2019Y0285]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [Y15H140003]
出版者	DOVE MEDICAL PRESS LTD
出版地	ALBANY
ISSN	1178-2013
EISSN	1178-2013
卷号	15 页码:5377-5387
DOI	10.2147/IJN.S248538
页数	11
WOS类目	Nanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS研究方向	Science & Technology - Other Topics ; Pharmacology & Pharmacy
WOS记录号	WOS:000553763200001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32848384
PMC记录号	PMC7425099
SCOPUSEID	2-s2.0-85088964486
通讯作者地址	[Sun, Xueli]Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province,Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,China ; [Deng, Hui]Department of Periodontics,School & Hospital of Stomatology,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Biophysics;Bioengineering;Biomaterials;Pharmaceutical Science;Drug Discovery;Organic Chemistry
TOP期刊	TOP期刊
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/9267
专题	口腔医学院、附属口腔医院口腔医学院、附属口腔医院_儿童口腔基础医学院（机能实验教学中心）_形态学系_组织胚胎学
通讯作者	Sun, Xueli; Deng, Hui
作者单位	1.Department of Periodontics,School & Hospital of Stomatology,Wenzhou Medical University,Wenzhou,China; 2.Department of Pediatric Dentistry,School & Hospital of Stomatology,Wenzhou Medical University,Wenzhou,China; 3.Department of Histology and Embryology,Wenzhou Medical University,Wenzhou,China; 4.Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province,Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,China; 5.Department of Dentistry,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Lin, Jian,He, Zhiqi,Liu, Fen,et al. Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with Sustained Drug Release and NIR-Responsive Photothermal Effect[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2020,15:5377-5387.
APA	Lin, Jian., He, Zhiqi., Liu, Fen., Feng, Jie., Huang, Chengyi., ... & Deng, Hui. (2020). Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with Sustained Drug Release and NIR-Responsive Photothermal Effect. INTERNATIONAL JOURNAL OF NANOMEDICINE, 15, 5377-5387.
MLA	Lin, Jian,et al."Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with Sustained Drug Release and NIR-Responsive Photothermal Effect".INTERNATIONAL JOURNAL OF NANOMEDICINE 15(2020):5377-5387.