Bioactive antibacterial silica-based nanocomposites hydrogel scaffolds with high angiogenesis for promoting diabetic wound healing and skin repair

doi:10.7150/thno.41839

科研成果详情

题名	Bioactive antibacterial silica-based nanocomposites hydrogel scaffolds with high angiogenesis for promoting diabetic wound healing and skin repair
作者	Li, Yannan 1,3; Xu, Tianzhen 2,5; Tu, Zhuolong 1; Dai, Wentong 1; Xue, Yumeng 4; Tang, Chengxuan2; Gao, Weiyang2; Mao, Cong2; Lei, Bo 4; Lin, Cai1
发表日期	2020
发表期刊	THERANOSTICS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	silica-based biomaterials bioactive scaffolds multifunctional properties diabetic wound healing tissue engineering
其他关键词	PEPTIDE HYDROGEL ; MATRIX ; GLASS ; BIOCOMPATIBILITY ; NANOPARTICLES ; FIBROBLAST ; DELIVERY
摘要	Diabetic wound repair and skin regeneration remains a worldwide challenge due to the impaired functionality of re-vascularization. Methods: This study reports a bioactive self-healing antibacterial injectable dual-network silica-based nanocomposite hydrogel scaffolds that can significantly enhance the diabetic wound healing/skin tissue formation through promoting early angiogenesis without adding any bioactive factors. The nanocomposite scaffold comprises a main network of polyethylene glycol diacrylate (PEGDA) forming scaffolds, with an auxiliary dynamic network formed between bioactive glass nanoparticles containing copper (BGNC) and sodium alginate (ALG) (PABC scaffolds). Results: PABC scaffolds exhibit the biomimetic elastomeric mechanical properties, excellent injectabilities, self-healing behavior, as well as the robust broad-spectrum antibacterial activity. Importantly, PABC hydrogel significantly promoted the viability, proliferation and angiogenic ability of endothelial progenitor cells (EPCs) in vitro. In vivo, PABC hydrogel could efficiently restore blood vessels networks through enhancing HIF-1 alpha/VEGF expression and collagen matrix deposition in the full-thickness diabetic wound, and significantly accelerate wound healing and skin tissue regeneration. Conclusion: The prominent multifunctional properties and angiogenic capacity of PABC hydrogel scaffolds enable their promising applications in angiogenesis-related regenerative medicine.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51872224]; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University [2018LHM-KFKT004]; Wenzhou Science & Technology Bureau project [ZY2019003]
出版者	IVYSPRING INT PUBL
出版地	LAKE HAVEN
ISSN	1838-7640
卷号	10 期号:11 页码:4929-4943
DOI	10.7150/thno.41839
页数	15
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
WOS记录号	WOS:000534489700002
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32308759
PMC记录号	PMC7163448
SCOPUSEID	2-s2.0-85083755477
通讯作者地址	[Mao, Cong]Key Laboratory of Orthopedics of Zhejiang Province,Second Affiliated Hospital,Yuying Children Hospital of Wenzhou Medical University,Wenzhou,325027,China ; [Lei, Bo]Frontier Institute of Science and Technology,Xi’an Jiaotong University,Xi’an,710054,China ; [Lin, Cai]Department of Burn,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Medicine (miscellaneous);Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
引用统计	被引频次：72[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/9228
专题	附属第一医院_烧伤科附属第二医院第二临床医学院、附属第二医院、育英儿童医院
通讯作者	Mao, Cong; Lei, Bo; Lin, Cai
作者单位	1.Department of Burn,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Key Laboratory of Orthopedics of Zhejiang Province,Second Affiliated Hospital,Yuying Children Hospital of Wenzhou Medical University,Wenzhou,325027,China; 3.School of Physical Science and Technology,Inner Mongolia University,Hohhot,010021,China; 4.Frontier Institute of Science and Technology,Xi’an Jiaotong University,Xi’an,710054,China; 5.Department of Orthopedics,Zhuji People's Hospital of Zhejiang Province,Shaoxing,312000,China
第一作者单位	附属第一医院
通讯作者单位	附属第二医院; 附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Li, Yannan,Xu, Tianzhen,Tu, Zhuolong,et al. Bioactive antibacterial silica-based nanocomposites hydrogel scaffolds with high angiogenesis for promoting diabetic wound healing and skin repair[J]. THERANOSTICS,2020,10(11):4929-4943.
APA	Li, Yannan., Xu, Tianzhen., Tu, Zhuolong., Dai, Wentong., Xue, Yumeng., ... & Lin, Cai. (2020). Bioactive antibacterial silica-based nanocomposites hydrogel scaffolds with high angiogenesis for promoting diabetic wound healing and skin repair. THERANOSTICS, 10(11), 4929-4943.
MLA	Li, Yannan,et al."Bioactive antibacterial silica-based nanocomposites hydrogel scaffolds with high angiogenesis for promoting diabetic wound healing and skin repair".THERANOSTICS 10.11(2020):4929-4943.