High Prevalence of Extended-Spectrum Beta Lactamases among Salmonella enterica Typhimurium Isolates from Pediatric Patients with Diarrhea in China

doi:10.1371/journal.pone.0016801

科研成果详情

题名	High Prevalence of Extended-Spectrum Beta Lactamases among Salmonella enterica Typhimurium Isolates from Pediatric Patients with Diarrhea in China
作者	Yu, Fangyou1; Chen, Qiang 2; Yu, Xiaojun 2; Li, Qiaoqiao3; Ding, Baixing 4; Yang, Lehe 3; Chen, Cong4; Qin, Zhiqiang 5; Parsons, Chris 5; Zhang, Xueqing1; Huang, Jinwei 6; Luo, Yun 7; Wang, Liangxing3; Pan, Jingye4
发表日期	2011-03-01
发表期刊	PLOS ONE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	GENOTYPE DISTRIBUTION ; SEROVAR ENTERITIDIS ; ESCHERICHIA-COLI ; RESISTANCE ; EMERGENCE ; GENES ; CTX-M-15 ; OUTBREAK
摘要	We investigated the extended-spectrum beta lactamases among 62 Salmonella enterica Typhimurium isolates recovered from children with diarrhea in a Chinese pediatric hospital. A large proportion of S. enterica Typhimurium isolates were resistant to multiple antimicrobial agents, including ampicillin (90.3%), tetracycline (80.6%), trimethoprim/sulfamethoxazole (74.2%), chloramphenicol (66.1%), cefotaxime (27.4%). Forty-nine (79.0%) of S. enterica Typhimurium isolates were positive for bla(TEM-1b) and resistant to ampicillin. Thirteen S. enterica Typhimurium isolates (21.0%) were positive for bla(CTX-M-1-group) and bla(CTX-M-9-group), and all isolates harboring bla(CTX-M) genes were positive for ISEcp1. Two main clones (PFGE type A and D) accounted for nearly 70% of S. enterica Typhimurium isolates, and 7 CTX-M-producing isolates belonged to PFGE type D. Collectively, our data reveal multi-drug resistance and a high prevalence of extended spectrum beta lactamases among S. enterica Typhimurium isolates from children in China. In addition, we report the first identification of bla(CTX-M-55) within Salmonella spp. Our data also suggest that clonal spread is responsible for the dissemination of S. enterica Typhimurium isolates.
资助项目	Medical Science Fund of Jiangxi Province, China [20094009, 20091256]
出版者	PUBLIC LIBRARY SCIENCE
出版地	SAN FRANCISCO
ISSN	1932-6203
卷号	6 期号:3 页码:e16801.
DOI	10.1371/journal.pone.0016801
页数	4
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000287932100004
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	21390297
PMC记录号	PMC3046957
SCOPUSEID	2-s2.0-79952292670
通讯作者地址	[Wang, Liangxing]Department of Respiratory Medicine,The First Affiliated Hospital of Wenzhou Medical College,China
Scopus学科分类	Multidisciplinary
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/9130
专题	检验医学院（生命科学学院、生物学实验教学中心）附属第一医院_呼吸内科附属第一医院_重症医学科（ICU）
通讯作者	Wang, Liangxing
作者单位	1.Department of Laboratory Medicine,The First Affiliated Hospital of Wenzhou Medical College,China; 2.Department of Laboratory Medicine,Jiangxi Provincial Children Hospital,China; 3.Department of Respiratory Medicine,The First Affiliated Hospital of Wenzhou Medical College,China; 4.Department of Intensive Care Unit,The First Affiliated Hospital of Wenzhou Medical College,China; 5.Division of Infectious Diseases,Department of Medicine,Medical University of South Carolina,United States; 6.Department of Laboratory Medicine,Lishui Center Hospital,China; 7.Department of Microbiology,Zhejiang Provincial Center for Disease Control and Prevention,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yu, Fangyou,Chen, Qiang,Yu, Xiaojun,et al. High Prevalence of Extended-Spectrum Beta Lactamases among Salmonella enterica Typhimurium Isolates from Pediatric Patients with Diarrhea in China[J]. PLOS ONE,2011,6(3):e16801..
APA	Yu, Fangyou., Chen, Qiang., Yu, Xiaojun., Li, Qiaoqiao., Ding, Baixing., ... & Pan, Jingye. (2011). High Prevalence of Extended-Spectrum Beta Lactamases among Salmonella enterica Typhimurium Isolates from Pediatric Patients with Diarrhea in China. PLOS ONE, 6(3), e16801..
MLA	Yu, Fangyou,et al."High Prevalence of Extended-Spectrum Beta Lactamases among Salmonella enterica Typhimurium Isolates from Pediatric Patients with Diarrhea in China".PLOS ONE 6.3(2011):e16801..