Isoliquiritigenin protects against sepsis-induced lung and liver injury by reducing inflammatory responses

doi:10.1016/j.bbrc.2017.11.159

科研成果详情

题名	Isoliquiritigenin protects against sepsis-induced lung and liver injury by reducing inflammatory responses
作者	Chen, Xiong1; Cai, Xueding2; Le, Rongrong3; Zhang, Man4; Gu, Xuemei1; Shen, Feixia1; Hong, Guangliang5; Chen, Zimiao1
发表日期	2018-02-05
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Lipopolysaccharide Isoliquiritigenin Sepsis Acute lung injury Inflammation
其他关键词	NF-KAPPA-B ; ACUTE KIDNEY INJURY ; LIQUIRITIGENIN ; CYTOKINES ; OUTCOMES
摘要	Sepsis, one of the most fatal diseases worldwide, often leads to multiple organ failure, mainly due to uncontrolled inflammatory responses. Despite accumulating knowledge obtained in recent years, effective drugs to treat sepsis in the clinic are still urgently needed. Isoliquiritigenin (ISL), a chalcone compound, has been reported to exert anti-inflammatory properties. However, little is known about the effects of ISL on sepsis and its related complications. In this study, we investigated the potential protective effects of ISL on lipopolysaccharide (LPS)-induced injuries and identified the mechanisms underlying these effects. ISL inhibited inflammatory cytokine expression in mouse primary peritoneal macrophages (MPMs) exposed to LPS. In an acute lung injury (ALI) mouse model, ISL prevented LPSi-nduced structural damage and inflammatory cell infiltration. Additionally, pretreatment with ISL attenuated sepsis-induced lung and liver injury, accompanied by a reduction in inflammatory responses. Moreover, these protective effects were mediated by the nuclear factor kappa B (NF-kappa B) pathway mediated inhibition of inflammatory responses in vitro and in vivo. Our study suggests that ISL may be a potential therapeutic agent for sepsis-induced injuries. (C) 2017 Published by Elsevier Inc.
资助项目	Public Welfare Science and Technology Program of Wenzhou City [Y20130238]; Natural Science Funding of Zhejiang Province [LY13H150006]
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
出版地	SAN DIEGO
ISSN	0006-291X
EISSN	1090-2104
卷号	496 期号:2 页码:245-252
DOI	10.1016/j.bbrc.2017.11.159
页数	8
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000424313500001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29180018
SCOPUSEID	2-s2.0-85040519657
通讯作者地址	[Chen, Zimiao]The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Biophysics;Biochemistry;Molecular Biology;Cell Biology
引用统计	被引频次：43[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/896
专题	附属第一医院附属第二医院第二临床医学院、附属第二医院、育英儿童医院眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者	Chen, Zimiao
作者单位	1.Department of Endocrinology,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China; 2.Department of Respiratory Medicine,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China; 3.The Affiliated Eye Hospital,Wenzhou Medical University,Wenzhou,China; 4.Department of Emergency,The Second Affiliated Hospital,Wenzhou Medical University,Wenzhou,China; 5.Department of Emergency,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Xiong,Cai, Xueding,Le, Rongrong,et al. Isoliquiritigenin protects against sepsis-induced lung and liver injury by reducing inflammatory responses[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,496(2):245-252.
APA	Chen, Xiong., Cai, Xueding., Le, Rongrong., Zhang, Man., Gu, Xuemei., ... & Chen, Zimiao. (2018). Isoliquiritigenin protects against sepsis-induced lung and liver injury by reducing inflammatory responses. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 496(2), 245-252.
MLA	Chen, Xiong,et al."Isoliquiritigenin protects against sepsis-induced lung and liver injury by reducing inflammatory responses".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 496.2(2018):245-252.