Modified poloxamer 407 and hyaluronic acid thermosensitive hydrogel-encapsulated keratinocyte growth factor 2 improves knee osteoarthritis in rats

doi:10.1016/j.matdes.2021.110086

科研成果详情

题名	Modified poloxamer 407 and hyaluronic acid thermosensitive hydrogel-encapsulated keratinocyte growth factor 2 improves knee osteoarthritis in rats
作者	Yang, Rongshuai 1,2,3; Chen, Min 1,3; Yang, Xuanxin1,2; Sun, Wenzhe 1,3; Lu, Chao 1,3; Hui, Qi1,3; Shi, Changcan 3,4; Li, Xiaokun2,3; Wang, Xiaojie 1,2,3
发表日期	2021-11-15
发表期刊	MATERIALS & DESIGN 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Thermosensitive hydrogel Poloxamer Hyaluronic acid Keratinocyte growth factor 2 Safety Osteoarthritis
其他关键词	INFLAMMATION ; IMPACT ; INJURY ; HIP
摘要	Osteoarthritis (OA) is one of the most common chronic diseases, causing degenerative changes in articular cartilage and subchondral bones. To date, there is no effective drug to delay the progression of OA in clinical practice. In this study, we synthesized and prepared a new thermosensitive hydrogel called PHA hydrogel, a mixture of normal poloxamer 407 and hyaluronic acid-modified poloxamer 407, and we investigated the effects of the PHA hydrogel loaded with keratinocyte growth factor 2 (KGF-2) on rats with papain-induced OA. First, we evaluated the safety of the PHA hydrogel in vitro and in vivo. The results showed that the PHA hydrogel had suitable osmotic pressure and no obvious cytotoxicity or adverse reactions after intra-articular injection. In addition, the PHA hydrogel improved the stability of KGF-2. Next, we studied the effects of the PHA hydrogel loaded with KGF-2 (PHA-KGF-2) on OA in rats. PHA-KGF-2 significantly improved the morphology and inflammation of the articular cartilage, reduced the loss of proteoglycan, and balanced collagen metabolism compared with KGF-2 alone. These data demonstrated that the PHA hydrogel is a safe biomaterial that can protect KGF-2, and thus is a promising therapeutic strategy for patients with OA. (c) 2021 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
资助项目	Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2016ZX09101117]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81971843]; CAMS Innovation Fund for Medical Sciences [2019-I2M5-028]; Wenzhou Science and Technology Major Project [ZY2020024]; Wenzhou Innovation Team [201801]
出版者	ELSEVIER SCI LTD
出版地	OXFORD
ISSN	0264-1275
EISSN	1873-4197
卷号	210
DOI	10.1016/j.matdes.2021.110086
页数	33
WOS类目	Materials Science, Multidisciplinary
WOS研究方向	Materials Science
WOS记录号	WOS:000697462500005
收录类别	SCIE ; EI ; SCOPUS
EI入藏号	20213610868561
EI主题词	Hydrogels
URL	查看原文
SCOPUSEID	2-s2.0-85114144301
通讯作者地址	[Wang, Xiaojie]Department of Dermatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Materials Science (all);Mechanics of Materials;Mechanical Engineering
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8957
专题	附属第一医院_皮肤科药学院（分析测试中心）
通讯作者	Wang, Xiaojie
作者单位	1.Department of Dermatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,China; 3.Research Units of Clinical Translation of Cell Growth Factors and Diseases,Research,Chinese Academy of Medical Science,Beijing,China; 4.Wenzhou Institute of Biomaterials and Engineering,Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 药学院（分析测试中心）
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yang, Rongshuai,Chen, Min,Yang, Xuanxin,et al. Modified poloxamer 407 and hyaluronic acid thermosensitive hydrogel-encapsulated keratinocyte growth factor 2 improves knee osteoarthritis in rats[J]. MATERIALS & DESIGN,2021,210.
APA	Yang, Rongshuai., Chen, Min., Yang, Xuanxin., Sun, Wenzhe., Lu, Chao., ... & Wang, Xiaojie. (2021). Modified poloxamer 407 and hyaluronic acid thermosensitive hydrogel-encapsulated keratinocyte growth factor 2 improves knee osteoarthritis in rats. MATERIALS & DESIGN, 210.
MLA	Yang, Rongshuai,et al."Modified poloxamer 407 and hyaluronic acid thermosensitive hydrogel-encapsulated keratinocyte growth factor 2 improves knee osteoarthritis in rats".MATERIALS & DESIGN 210(2021).