Two new Cu (II) complexes based on 5-fluorouracil-1-yl acetic acid and N-donor ligands: Investigation of their interaction with DNA and anticancer activity

doi:10.1002/aoc.6458

科研成果详情

题名	Two new Cu (II) complexes based on 5-fluorouracil-1-yl acetic acid and N-donor ligands: Investigation of their interaction with DNA and anticancer activity
作者	Xi, Yun-Hong 1; Yan, Xin 1; Bigdeli, Fahime 2; Zhang, Qianwen3; Esrafili, Leili 2; Hanifehpour, Younes 4; Zhang, Wei-Bing 1; Hu, Mao-Lin 1; Morsali, Ali 2
发表日期	2022-01
发表期刊	APPLIED ORGANOMETALLIC CHEMISTRY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	5-Fluorouracil-1-yl acetic acid anticancer cu (II) complex DNA electrostatic interaction
其他关键词	COPPER(II) COMPLEXES ; ANTITUMOR ACTIVITIES ; MOLECULAR DOCKING ; CRYSTAL-STRUCTURE ; BINDING ; CLEAVAGE
摘要	Two new Cu (II) complexes [Cu (bpy)(2)L1] BF4.CH3OH (Z(3)) and [Cu (phen)(2)L1] BF4 center dot H2O (Z9), L1 = 5-Fluorouracil-1-yl Acetic Acid, were synthesized based on 5-Fluorouracil-1-yl Acetic Acid and 2,2 '-Bipyridine or 1,10-phenanthroline ligands and their anticancer activity toward human cancer cell lines investigated. The complexes were characterized by infrared (IR) spectra, elemental analysis, and X-ray crystallography. The interaction of the complexes with CT-DNA was investigated by UV-vis absorption and fluorescence spectroscopies, and cyclic voltammetry; cell viability (%) was studied using the absorbance amount of the samples. The interaction mode of the complexes with DNA is electrostatic, and the complexes displayed good anticancer activity against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with best IC50 amount of 11.31 +/- 0.74 mu M for Z9. The results showed that the nature of the nitrogen-donor ligand is very effective in the anticancer activity of the complexes.
资助项目	Tarbiat Modares University; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21571143]; Wenzhou Basic Scientific Research Project [2020G0076]
出版者	WILEY
出版地	HOBOKEN
ISSN	0268-2605
EISSN	1099-0739
卷号	36 期号:1
DOI	10.1002/aoc.6458
页数	12
WOS类目	Chemistry, Applied ; Chemistry, Inorganic & Nuclear
WOS研究方向	Chemistry
WOS记录号	WOS:000697152600001
收录类别	SCIE ; EI ; SCOPUS
EI入藏号	20213810916991
EI主题词	Copper compounds
EI分类号	461.2 Biological Materials and Tissue Engineering ; 723.5 Computer Applications ; 741.3 Optical Devices and Systems ; 801 Chemistry ; 802.2 Chemical Reactions ; 804.1 Organic Compounds ; 933.1.1 Crystal Lattice
URL	查看原文
Scopus记录号	2-s2.0-85115067892
通讯作者地址	[Zhang, Wei-Bing]College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou,China
scopus学科分类	Chemistry (all);Inorganic Chemistry
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8956
专题	附属第一医院_皮肤科
通讯作者	Zhang, Wei-Bing
作者单位	1.College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou,China; 2.Department of Chemistry,Faculty of Sciences,Tarbiat Modares University,Tehran,Iran; 3.Department of Dermatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 4.Faculty of Science,Department of Chemistry,Sayyed Jamaleddin Asadabadi University,Asadabad,Iran
推荐引用方式 GB/T 7714	Xi, Yun-Hong,Yan, Xin,Bigdeli, Fahime,et al. Two new Cu (II) complexes based on 5-fluorouracil-1-yl acetic acid and N-donor ligands: Investigation of their interaction with DNA and anticancer activity[J]. APPLIED ORGANOMETALLIC CHEMISTRY,2022,36(1).
APA	Xi, Yun-Hong., Yan, Xin., Bigdeli, Fahime., Zhang, Qianwen., Esrafili, Leili., ... & Morsali, Ali. (2022). Two new Cu (II) complexes based on 5-fluorouracil-1-yl acetic acid and N-donor ligands: Investigation of their interaction with DNA and anticancer activity. APPLIED ORGANOMETALLIC CHEMISTRY, 36(1).
MLA	Xi, Yun-Hong,et al."Two new Cu (II) complexes based on 5-fluorouracil-1-yl acetic acid and N-donor ligands: Investigation of their interaction with DNA and anticancer activity".APPLIED ORGANOMETALLIC CHEMISTRY 36.1(2022).