Enhancing chemotherapeutic drug inhibition on tumor growth by ultrasound: an in vivo experiment

doi:10.3109/10611861003801834

科研成果详情

题名	Enhancing chemotherapeutic drug inhibition on tumor growth by ultrasound: an in vivo experiment
作者	Zhao, Ying-Zheng1; Lu, Cui-Tao1; Zhou, Zhi-Cai 1; Jin, Zhuo 1; Zhang, Lu 1; Sun, Chang-Zheng 1; Xu, Yan-Yan 1; Gao, Hui-Sheng 1; Tian, Ji-Lai 1; Gao, Feng-Hou 2; Tang, Qin-Qin1; Li, Wei 3; Xiang, Qi 4; Li, Xiao-Kun1; Li, Wen-Feng5
发表日期	2011-02
发表期刊	JOURNAL OF DRUG TARGETING 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Ultrasound tumor growth inhibition epirubicin hydrochloride
其他关键词	PHOSPHOLIPIDS-BASED MICROBUBBLES ; AGENT GAS BODIES ; CONTRAST-AGENT ; VITRO ; CELLS ; SONOPORATION ; TRANSFECTION ; LIPOSOMES ; DELIVERY
摘要	An in vivo study on enhancing epirubicin hydrochloride (EPI) inhibition on tumor growth by ultrasound (US) was reported. Five-week-old male nude mice were used and HL-60 cells were s.c. (subcutaneous injection) inoculated in axilla of these mice. Six groups were designed and five consecutive treatments were applied to investigate the inhibition on tumor growth and body weight growth. US applied locally to the tumor resulted in a substantially increased drug uptake in tumor cells. The inhibition on tumor growth depended on the position of drug injection and phospholipid-based microbubble (PMB) application. Tumor growth rate under group 1 (PMB+US) was similar to that of blank control. The order of the inhibition on tumor volume growth was: group 4 (s.c. EPI+PMB+US) > group 5 intraperitoneal (i.p. EPI+PMB+US) > group 2 (i.p. EPI) > group 3 (s.c. EPI+US) > group 1 (PMB+US). Similar conclusion was obtained from experimental measurements of tumor weight change. The order of animal survival status for EPI administration groups was: group 4 > group 5 > group 2 > group 3. Chemotherapeutic drug inhibition on tumor growth could be enhanced by local US combined with PMB, which might provide a potential application for US-mediated chemotherapy.
资助项目	National Natural Science Funds of ChinaNational Natural Science Foundation of China (NSFC) [30870755]; Wenzhou Bureau of Science and Technology [Y20090109, Y20080098]; Zhejiang Province Funds for Talented Youth in Medical Technology [2009QN022]; Zhejiang Province Extremely Key Subject Building Funds; Ministry of Education
出版者	INFORMA HEALTHCARE
出版地	LONDON
ISSN	1061-186X
EISSN	1029-2330
卷号	19 期号:2 页码:154-160
DOI	10.3109/10611861003801834
页数	7
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000285553000009
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	20429773
SCOPUSEID	2-s2.0-78650527795
通讯作者地址	[Zhao, Ying-Zheng]Pharmacy School,Wenzhou Medical College,China
Scopus学科分类	Pharmaceutical Science
引用统计	被引频次：33[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8912
专题	药学院（分析测试中心）附属第一医院_肿瘤内科
通讯作者	Zhao, Ying-Zheng
作者单位	1.Pharmacy School,Wenzhou Medical College,China; 2.People's Hospital,Shanghai Jiaotong University,School of Medicine,China; 3.Zhejiang Provincial Key Laboratory of Medical Genetics,Wenzhou Medical College,China; 4.Biopharmaceutical R and D Center of Jinan University,China; 5.Oncology Department,First Affiliated Hospital,Wenzhou Medical College,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Zhao, Ying-Zheng,Lu, Cui-Tao,Zhou, Zhi-Cai,et al. Enhancing chemotherapeutic drug inhibition on tumor growth by ultrasound: an in vivo experiment[J]. JOURNAL OF DRUG TARGETING,2011,19(2):154-160.
APA	Zhao, Ying-Zheng., Lu, Cui-Tao., Zhou, Zhi-Cai., Jin, Zhuo., Zhang, Lu., ... & Li, Wen-Feng. (2011). Enhancing chemotherapeutic drug inhibition on tumor growth by ultrasound: an in vivo experiment. JOURNAL OF DRUG TARGETING, 19(2), 154-160.
MLA	Zhao, Ying-Zheng,et al."Enhancing chemotherapeutic drug inhibition on tumor growth by ultrasound: an in vivo experiment".JOURNAL OF DRUG TARGETING 19.2(2011):154-160.