Upregulation of the long noncoding RNAs DSCAM-AS1 and MANCR is a potential diagnostic marker for breast carcinoma

doi:10.1002/bab.2048

科研成果详情

题名	Upregulation of the long noncoding RNAs DSCAM-AS1 and MANCR is a potential diagnostic marker for breast carcinoma
作者	Tahmouresi, Fatemeh 1; Razmara, Ehsan 2; Pakravan, Katayoon 3; Mossahebi-Mohammadi, Majid 4; Rouhollah, Fatemeh 5; Montazeri, Maryam 6; Sarrafzadeh, Alireza 7; Fahimi, Hossein 1; Babashah, Sadegh 3
发表日期	2021-12
发表期刊	BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	biomarker breast cancer diagnosis LncRNAs
其他关键词	CELL-CYCLE ; CANCER ; LNCRNA ; PROLIFERATION ; APOPTOSIS ; MIGRATION ; INVASION ; PCR
摘要	Breast cancer (BC) is one of the most common malignancies among women in the world. There is a global attempt to diagnose BC as early as possible. Long noncoding RNAs (lncRNAs) are emerging as novel targets and biomarkers for BC diagnosis and prognosis. Aberrant expression of lncRNAs is associated with BC development, making them a potential tumor marker for BC. To investigate this possibility, we determined the expression levels of Down syndrome cell adhesion molecule-antisense RNA-1 (DSCAM-AS1) and mitotically-associated long non-coding RNA (MANCR) lncRNAs in BC tissues. This case-control study included 50 paired tumor and adjacent nontumor tissues from female BC patients. The total RNA was isolated and the expression levels of MANCR and DSCAM-AS1 lncRNAs were assessed using quantitative real-time reverse transcription-PCR. Potential correlations between lncRNA levels and clinicopathological characteristics were also analyzed. DSCAM-AS1 and MANCR lncRNAs were significantly upregulated in BC tumor tissues compared with the adjacent nontumor tissues. We also found the significant upregulation of DSCAM-AS1 in advanced tumor-node-metastasis stage (TNM III) of BC tumor tissues. Furthermore, the expression of DSCAM-AS1 and MANCR in HER-2 positive patients was significantly higher than HER-2 negative affected individuals. Receiver operating characteristic curve analysis showed a satisfactory diagnostic efficacy (Pvalue < 0.0001), which means that DSCAM-AS1 and MANCR lncRNAs can potentially serve as a biomarker. The present study might provide further approval for the clinical diagnostic significance of DSCAM-AS1 and MANCR lncRNAs that their high expressions were associated with aggressive clinical parameters of BC.
出版者	WILEY
出版地	HOBOKEN
ISSN	0885-4513
EISSN	1470-8744
卷号	68 期号:6 页码:1250-1256
DOI	10.1002/bab.2048
页数	40
WOS类目	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
WOS研究方向	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
WOS记录号	WOS:000577265000001
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20204209347259
EI主题词	Diagnosis
URL	查看原文
Pubmed记录号	33012018
Scopus记录号	2-s2.0-85092355588
通讯作者地址	[Fahimi, Hossein]Department of Genetics,Faculty of Advanced Sciences and Technology,Tehran Medical Sciences,Islamic Azad University,Tehran,Iran ; [Babashah, Sadegh]Department of Molecular Genetics,Faculty of Biological Sciences,Tarbiat Modares University,Tehran,Iran
scopus学科分类	Biotechnology;Bioengineering;Molecular Medicine;Biomedical Engineering;Applied Microbiology and Biotechnology;Drug Discovery;Process Chemistry and Technology
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8817
专题	药学院（分析测试中心）卓越中心_国际生长因子研究院
通讯作者	Fahimi, Hossein; Babashah, Sadegh
作者单位	1.Department of Genetics,Faculty of Advanced Sciences and Technology,Tehran Medical Sciences,Islamic Azad University,Tehran,Iran; 2.Department of Medical Genetics,Faculty of Medical Sciences,Tarbiat Modares University,Tehran,Iran; 3.Department of Molecular Genetics,Faculty of Biological Sciences,Tarbiat Modares University,Tehran,Iran; 4.School of Pharmaceutical Sciences and International Collaborative Center on Growth Factor Research,Wenzhou Medical University,Wenzhou,China; 5.Department of Cellular and Molecular Sciences,Faculty of Advanced Sciences and Technology,Tehran Medical Sciences,Islamic Azad University,Tehran,Iran; 6.Department of Medical Biotechnology,Faculty of Advanced Science and Technology,Tehran Medical Sciences,Islamic Azad University,Tehran,Iran; 7.Laleh General Hospital,Tehran,Iran
推荐引用方式 GB/T 7714	Tahmouresi, Fatemeh,Razmara, Ehsan,Pakravan, Katayoon,et al. Upregulation of the long noncoding RNAs DSCAM-AS1 and MANCR is a potential diagnostic marker for breast carcinoma[J]. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY,2021,68(6):1250-1256.
APA	Tahmouresi, Fatemeh., Razmara, Ehsan., Pakravan, Katayoon., Mossahebi-Mohammadi, Majid., Rouhollah, Fatemeh., ... & Babashah, Sadegh. (2021). Upregulation of the long noncoding RNAs DSCAM-AS1 and MANCR is a potential diagnostic marker for breast carcinoma. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 68(6), 1250-1256.
MLA	Tahmouresi, Fatemeh,et al."Upregulation of the long noncoding RNAs DSCAM-AS1 and MANCR is a potential diagnostic marker for breast carcinoma".BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY 68.6(2021):1250-1256.