Studies of macrophage immuno-modulating activity of polysaccharides isolated from Paecilomyces tenuipes

doi:10.1016/j.ijbiomac.2008.06.004

科研成果详情

题名	Studies of macrophage immuno-modulating activity of polysaccharides isolated from Paecilomyces tenuipes
作者	Chen, Xiaoming1,2; Lu, Jianxin 2,3; Zhang, Yangde 3; He, Jiantai 3; Guo, Xunzhi 3; Tian, Gengyuan 2,4; Jin, Liqin1,2
发表日期	2008-10-01
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Paecilomyces sinensis polysaccharides immunodulatory
其他关键词	INNATE
摘要	The objective of this study was to evaluate the immunomodulatory effects of the Paecilomyces sinensis polysaccharides (PtP) on the activity of macrophages and human monocytes. A water-soluble polysaccharide, with estimated molecular weight of 2.04 x 10(4) Da, was isolated from P. sinensis. The results indicate that PtP can increase the activity of LDH and ACP in AM phi and PM phi of rats and human mononuclear cells, and enhance the pinocytic activity of macrophages and TNF-alpha production by human peripheral blood mononuclear cells (PBMC), suggesting that PtP had potent immunomodulatory properties and could be explored as a novel potential immunostimulants for the food and pharmaceutical purpose. (C) 2008 Elsevier B.V. All rights reserved.
资助项目	Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [301036]
出版者	ELSEVIER SCIENCE BV
出版地	AMSTERDAM
ISSN	0141-8130
卷号	43 期号:3 页码:252-256
DOI	10.1016/j.ijbiomac.2008.06.004
页数	5
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS记录号	WOS:000259546000006
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	18601946
SCOPUSEID	2-s2.0-49749139342
通讯作者地址	[Zhang, Yangde]The National Hepatobiliary and Enteric Surgery Research Center,Ministry of Health,Central South University,China
Scopus学科分类	Structural Biology;Biochemistry;Molecular Biology
TOP期刊	TOP期刊
引用统计	被引频次：47[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8810
专题	检验医学院（生命科学学院、生物学实验教学中心）_细胞与分子生物医学研究所检验医学院（生命科学学院、生物学实验教学中心）
通讯作者	Zhang, Yangde
作者单位	1.Institute of Cellular and Molecular Medicine,School of Laboratory Medicine,Wenzhou Medical College,China; 2.Zhejiang Provincial Key Laboratory of Medical Genetics,School of Laboratory Medicine,Wenzhou Medical College,China; 3.The National Hepatobiliary and Enteric Surgery Research Center,Ministry of Health,Central South University,China; 4.State Key Laboratory of Bio-organic and Natural Products Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,China
第一作者单位	检验医学院（生命科学学院、生物学实验教学中心）_细胞与分子生物医学研究所; 检验医学院（生命科学学院、生物学实验教学中心）
第一作者的第一单位	检验医学院（生命科学学院、生物学实验教学中心）_细胞与分子生物医学研究所
推荐引用方式 GB/T 7714	Chen, Xiaoming,Lu, Jianxin,Zhang, Yangde,et al. Studies of macrophage immuno-modulating activity of polysaccharides isolated from Paecilomyces tenuipes[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2008,43(3):252-256.
APA	Chen, Xiaoming., Lu, Jianxin., Zhang, Yangde., He, Jiantai., Guo, Xunzhi., ... & Jin, Liqin. (2008). Studies of macrophage immuno-modulating activity of polysaccharides isolated from Paecilomyces tenuipes. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 43(3), 252-256.
MLA	Chen, Xiaoming,et al."Studies of macrophage immuno-modulating activity of polysaccharides isolated from Paecilomyces tenuipes".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 43.3(2008):252-256.