Depletion of CABYR-a/b sensitizes lung cancer cells to TRAIL-induced apoptosis through YAP/p73-mediated DR5 upregulation

doi:10.18632/oncotarget.7069

科研成果详情

题名	Depletion of CABYR-a/b sensitizes lung cancer cells to TRAIL-induced apoptosis through YAP/p73-mediated DR5 upregulation
作者	Xiao, Qianqian 1; Qian, Zunlei 1,2; Zhang, Weiqing 1; Liu, Jin 1; Hu, Enze 1; Zhang, Jinsan3; Li, Mingying 1,4; Wang, Junhao 1; Kong, Fei 1; Li, Yunguang 1; Wang, Rui 1; Tan, Xiaohua3; He, Dacheng 1; Xiao, Xueyuan 1
发表日期	2016-02-23
发表期刊	ONCOTARGET 影响因子和分区
语种	英语
原始文献类型	Article
关键词	CABYR-a/b lung cancer cells DR5 TRAIL YAP
其他关键词	YES-ASSOCIATED PROTEIN ; APO-2 LIGAND ; DNA-DAMAGE ; P73 ; ACTIVATION ; AKT ; PHOSPHORYLATION ; IDENTIFICATION ; FAMILY ; MEMBER
摘要	Our previous study revealed that knockdown of CABYR-a/b increases the chemosensitivity of lung cancer cells through inactivation of Akt. Here, we demonstrated that depletion of CABYR-a/b significantly increased DR5 expression and sensitized lung cancer cells to TRAIL-induced apoptosis in vitro and/or in vivo. Importantly, treatment with AD5-10, a DR5-specific agonistic monoclonal antibody, was able to mimic TRAIL-induced apoptosis in CABYR-a/b-silenced cells. Strikingly, we identified that depletion of CABYR-a/b not only increased the expressions of p73 and DR5 but also decreased the phosphorylation of YAP S127. Loss-or gain-of-function studies of YAP and p73 revealed that double deletions of YAP and p73 effectively decreased the expression of DR5 and abolished TRAIL-induced apoptosis in CABYR-a/b knockdown cells. Conversely, the co-overexpression of YAP and p73 promoted the expression of DR5 and sensitized cells to TRAIL-induced apoptosis. Taken together, our results demonstrate that depletion of CABYR-a/b sensitizes lung cancer cells to TRAIL-induced apoptosis through YAP/p73-mediated DR5 upregulation.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81172216, 81272604]; Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2011CB915504]; Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education [LCPRB201403]
出版者	IMPACT JOURNALS LLC
出版地	ORCHARD PARK
ISSN	1949-2553
EISSN	1949-2553
卷号	7 期号:8 页码:9514-9525
DOI	10.18632/oncotarget.7069
页数	12
WOS类目	Oncology ; Cell Biology
WOS研究方向	Oncology ; Cell Biology
WOS记录号	WOS:000375618100079
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	26843620
PMC记录号	PMC4891056
SCOPUSEID	2-s2.0-84961603895
通讯作者地址	[Xiao, Xueyuan]Key laboratory of Cell Proliferation and Regulation Biology,Ministry of Education,Beijing Normal University,Beijing,China
Scopus学科分类	Oncology
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8798
专题	药学院（分析测试中心）药学院（分析测试中心）_生物制药系_生物制药工程
通讯作者	Xiao, Xueyuan
作者单位	1.Key laboratory of Cell Proliferation and Regulation Biology,Ministry of Education,Beijing Normal University,Beijing,China; 2.College of Forensic Sciences,People's Public Security University of China,Beijing,China; 3.School of Pharmaceutical Sciences,Key Laboratory of Biotechnology and Pharmaceutical Engineering,Wenzhou Medical University,Wenzhou, Zhejiang,China; 4.Center of Reproduction and Genetics,First People's Hospital of Yunnan Province,Kunming,China
推荐引用方式 GB/T 7714	Xiao, Qianqian,Qian, Zunlei,Zhang, Weiqing,et al. Depletion of CABYR-a/b sensitizes lung cancer cells to TRAIL-induced apoptosis through YAP/p73-mediated DR5 upregulation[J]. ONCOTARGET,2016,7(8):9514-9525.
APA	Xiao, Qianqian., Qian, Zunlei., Zhang, Weiqing., Liu, Jin., Hu, Enze., ... & Xiao, Xueyuan. (2016). Depletion of CABYR-a/b sensitizes lung cancer cells to TRAIL-induced apoptosis through YAP/p73-mediated DR5 upregulation. ONCOTARGET, 7(8), 9514-9525.
MLA	Xiao, Qianqian,et al."Depletion of CABYR-a/b sensitizes lung cancer cells to TRAIL-induced apoptosis through YAP/p73-mediated DR5 upregulation".ONCOTARGET 7.8(2016):9514-9525.