Zinc oxide nanoparticles induce toxic responses in human neuroblastoma SHSY5Y cells in a size-dependent manner

doi:10.2147/IJN.S149070

科研成果详情

题名	Zinc oxide nanoparticles induce toxic responses in human neuroblastoma SHSY5Y cells in a size-dependent manner
作者	Liu, Jia 1; Kang, Yiyuan 1; Yin, Suhan 1; Song, Bin 2; Wei, Limin3; Chen, Liangjiao 4; Shao, Longquan 1
发表日期	2017-12-31
发表期刊	INTERNATIONAL JOURNAL OF NANOMEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	zinc oxide nanoparticles SHSY5Y cells reactive oxygen species apoptosis cell cytoskeleton
其他关键词	SK-N-SH ; OXIDATIVE STRESS ; ZNO NANOPARTICLES ; IN-VITRO ; INTRACELLULAR DISSOLUTION ; INFLAMMATORY RESPONSES ; SILVER NANOPARTICLES ; CARCINOMA-CELLS ; HUMAN MONOCYTES ; DISSOLVED ZINC
摘要	Due to the widespread applications of zinc oxide nanoparticles (ZnO NPs), the potential exposure of workers, consumers, and scientists to these particles has increased. This potential for exposure has attracted extensive attention in the science community. Many studies have examined the toxicological profile of ZnO NPs in the immune system, digestive system, however, information regarding the toxicity of ZnO NPs in the nervous system is scarce. In this study, we detected the cytotoxicity of two types of ZnO NPs of various sizes - ZnOa NPs and ZnOb NPs - and we characterized the shedding ability of zinc ions within culture medium and the cytoplasm. We found that reactive oxygen species played a crucial role in ZnO NP-induced cytotoxicity, likely because zinc ions were leached from ZnO NPs. Apoptosis and cytoskeleton changes were also toxic responses induced by the ZnO NPs, and ZnOb NPs induced more significant toxic responses than ZnOa NPs in SHSY5Y cells. In conclusion, ZnO NPs induced toxic responses in SHSY5Y cells in a size-dependent manner, which can probably be attributed to their ion-shedding ability.
资助项目	National Key Research and Development Program of China [2016YFC1102601, 2016YFC1102603]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51672122, 81600904]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2015A030313299, 2016A030313673]
出版者	DOVE MEDICAL PRESS LTD
出版地	ALBANY
ISSN	1178-2013
EISSN	1178-2013
卷号	12 页码:8085-8099
DOI	10.2147/IJN.S149070
页数	15
WOS类目	Nanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS研究方向	Science & Technology - Other Topics ; Pharmacology & Pharmacy
WOS记录号	WOS:000414171400001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29138564
PMC记录号	PMC5677299
SCOPUSEID	2-s2.0-85032788370
通讯作者地址	[Shao, Longquan]Department of Stomatology,Nanfang Hospital,Southern Medical University,1838 Guangzhou North Avenue, Baiyun Qu,Guangzhou,510515,China
Scopus学科分类	Biophysics;Bioengineering;Biomaterials;Pharmaceutical Science;Drug Discovery;Organic Chemistry
TOP期刊	TOP期刊
引用统计	被引频次：50[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8795
专题	口腔医学院、附属口腔医院_儿童口腔
通讯作者	Shao, Longquan
作者单位	1.Department of Stomatology,Nanfang Hospital,Southern Medical University,Guangzhou,China; 2.Department of Stomatology,Guizhou Provincial People’s Hospital,Guiyang,China; 3.Department of Pediatric Dentistry,School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,China; 4.Key Laboratory of Oral Medicine,Guangzhou Institute of Oral Disease,Stomatology Hospital of Guangzhou Medical University,Guangzhou,China
推荐引用方式 GB/T 7714	Liu, Jia,Kang, Yiyuan,Yin, Suhan,et al. Zinc oxide nanoparticles induce toxic responses in human neuroblastoma SHSY5Y cells in a size-dependent manner[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12:8085-8099.
APA	Liu, Jia., Kang, Yiyuan., Yin, Suhan., Song, Bin., Wei, Limin., ... & Shao, Longquan. (2017). Zinc oxide nanoparticles induce toxic responses in human neuroblastoma SHSY5Y cells in a size-dependent manner. INTERNATIONAL JOURNAL OF NANOMEDICINE, 12, 8085-8099.
MLA	Liu, Jia,et al."Zinc oxide nanoparticles induce toxic responses in human neuroblastoma SHSY5Y cells in a size-dependent manner".INTERNATIONAL JOURNAL OF NANOMEDICINE 12(2017):8085-8099.