Hydrogel composite scaffolds with an attenuated immunogenicity component for bone tissue engineering applications

doi:10.1039/d0tb02588g

科研成果详情

题名	Hydrogel composite scaffolds with an attenuated immunogenicity component for bone tissue engineering applications
作者	Gao, Chenyuan 1,2; Sow, Wan Ting 2; Wang, Yingying 3; Wang, Yili 2; Yang, Dejun 2,3; Lee, Bae Hoon 2,3; Matičić, Dražen 4; Fang, Lian5; Li, Huaqiong1,2; Zhang, Chunwu1
发表日期	2021-02-28
发表期刊	JOURNAL OF MATERIALS CHEMISTRY B 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Biocompatibility Biomechanics Cell culture Composite structures Compressive strength Computerized tomography Hydrogels Stem cells Tissue Tissue regeneration Bone defect models Bone regeneration Bone tissue engineering Human bone marrow mesenchymal stem cells Hybrid scaffolds Hydrogel composites Osteogenic differentiation Strength and stiffness
摘要	Xenogeneic bones are potential templates for bone regeneration. In this study, decellularized porcine bone powder with attenuated immunogenicity was incorporated into a photocurable hydrogel, gelatin methacryloyl (GelMA), to obtain scaffolds with good mechanical properties for bone tissue engineering. The decellularized bone powder (DCB)-GelMA hybrid scaffolds had higher compressive strength and stiffness values when the DCB content was increased. In vitro evaluations revealed the biocompatibility of these scaffolds. The scaffolds could induce human bone marrow mesenchymal stem cells (hMSCs) to undergo osteogenic differentiation even in the absence of an induction medium. The efficiency of the scaffolds for bone regeneration applications was further evaluated using an in vivo cranial bone defect model in rats. Micro-CT images showed that the hybrid scaffolds with 20% DCB content had the best effect in promoting new bone regeneration. Thus, it was concluded that the DCB-GelMA hybrid scaffolds have high potential in bone tissue engineering applications.
资助项目	Zhejiang Provincial Natural Science of Foundation of China [Y20C070010]; 9th Session of the Croatia-China Scientific and Technological Cooperation Committee Researchers Exchange Program; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81601626]; Wenzhou Institute; University of Chinese Academy of SciencesChinese Academy of Sciences [WIUCASQD2019002]; 111 ProjectMinistry of Education, China - 111 Project
出版者	ROYAL SOC CHEMISTRY
出版地	CAMBRIDGE
ISSN	2050-750X
EISSN	2050-7518
卷号	9 期号:8 页码:2033-2041
DOI	10.1039/d0tb02588g
页数	32
WOS类目	Materials Science, Biomaterials
WOS研究方向	Materials Science
WOS记录号	WOS:000625812200010
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20211010049712
EI主题词	Scaffolds (biology)
URL	查看原文
PubMed ID	33587079
SCOPUSEID	2-s2.0-85102054588
通讯作者地址	[Li, Huaqiong]Department of Orthopaedics,Joint Centre of Translational Medicine,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Chemistry (all);Biomedical Engineering;Materials Science (all)
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8673
专题	眼视光学院（生物医学工程学院）、附属眼视光医院附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_耳鼻咽喉科学_耳鼻喉
通讯作者	Li, Huaqiong
作者单位	1.Department of Orthopaedics,Joint Centre of Translational Medicine,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China; 2.Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province,Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,325011,China; 3.School of Biomedical Engineering,School of Ophthalmology & Optometry and Eye Hospital,Wenzhou Medical University,Wenzhou,325035,China; 4.Faculty of Veterinary Medicine,University of Zagreb,Zagreb,10000,Croatia; 5.ENT Department,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Gao, Chenyuan,Sow, Wan Ting,Wang, Yingying,et al. Hydrogel composite scaffolds with an attenuated immunogenicity component for bone tissue engineering applications[J]. JOURNAL OF MATERIALS CHEMISTRY B,2021,9(8):2033-2041.
APA	Gao, Chenyuan., Sow, Wan Ting., Wang, Yingying., Wang, Yili., Yang, Dejun., ... & Zhang, Chunwu. (2021). Hydrogel composite scaffolds with an attenuated immunogenicity component for bone tissue engineering applications. JOURNAL OF MATERIALS CHEMISTRY B, 9(8), 2033-2041.
MLA	Gao, Chenyuan,et al."Hydrogel composite scaffolds with an attenuated immunogenicity component for bone tissue engineering applications".JOURNAL OF MATERIALS CHEMISTRY B 9.8(2021):2033-2041.