题名 | Long-Term Recruitment of Endogenous M2 Macrophages by Platelet Lysate-Rich Plasma Macroporous Hydrogel Scaffold for Articular Cartilage Defect Repair |
作者 | |
发表日期 | 2022-03 |
发表期刊 | ADVANCED HEALTHCARE MATERIALS 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article ; Early Access |
关键词 | cartilage repair endogenous M2 macrophages long-term recruitment macroporous hydrogel scaffolds platelet lysate-rich plasma |
其他关键词 | MESENCHYMAL STEM-CELLS ; POLARIZATION ; INFLAMMATION ; REGENERATION ; MECHANISMS ; PHENOTYPE ; DELIVERY ; COLLAGEN |
摘要 | After cartilage damage, a large number of monocytes/macrophages infiltrate into adjacent synovium and the resident macrophages in synovial tissue transform to activated macrophages (M1), which secrete pro-inflammatory cytokines to induce sustained inflammation and chondrocyte apoptotic. However, current clinical therapies for cartilage repair can rarely achieve long-term anti-inflammatory regulation and satisfactory outcomes. Herein, a platelet lysate-rich plasma macroporous hydrogel (PLPMH) scaffold with around 100 mu m pore size and 1.25 MPa Young's modulus is developed to sustainedly recruit and polarize endogenous anti-inflammatory macrophages (M2) for improving cartilage defect repair. PLPMH scaffold can steadily release sphingosine1-phosphate and proteins via gradual degradation, thus inducing M2 macrophages migration or resting (M0) macrophages migration and then polarization to M2 phenotype, and improving the secretion of anti-inflammatory cytokines. Furthermore, PLPMH scaffold exhibits negligible inflammatory responses in vivo and promotes endogenous M2 macrophage infiltration in large numbers and long-time duration to provide a local anti-inflammatory microenvironment, which even lasts for 42 d. In a rabbit model of cartilage defect, PLPMH scaffold increases the ratio of M2 macrophages and improves cartilage tissue regeneration. These studies support that PLPMH scaffold may have a great potential in articular cartilage tissue engineering by providing an anti-inflammatory and pro-regenerative microenvironment. |
资助项目 | National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31971260]; Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholar [LR20C100001]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LY19C100002, LY21H060008]; Key Laboratory of Orthopaedics of Zhejiang Province [ZJGK1804Y]; Wenzhou Scientific Research Project [Y20190136]; Wenzhou Institute, University of Chinese Academy of Sciences [WIUCASQD2019004] |
出版者 | WILEY |
出版地 | HOBOKEN |
ISSN | 2192-2640 |
EISSN | 2192-2659 |
卷号 | 11期号:6页码:e2101661. |
DOI | 10.1002/adhm.202101661 |
页数 | 55 |
WOS类目 | Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials |
WOS研究方向 | Engineering ; Science & Technology - Other Topics ; Materials Science |
WOS记录号 | WOS:000739897400001 |
收录类别 | SCIE ; PUBMED ; EI ; SCOPUS |
EI入藏号 | 20220311466876 |
EI主题词 | Macrophages |
EI分类号 | 461.1 Biomedical Engineering ; 461.2 Biological Materials and Tissue Engineering ; 461.9 Biology ; 461.9.1 Immunology ; 801.3 Colloid Chemistry ; 804 Chemical Products Generally ; 913.5 Maintenance ; 931.2 Physical Properties of Gases, Liquids and Solids ; 951 Materials Science |
URL | 查看原文 |
PubMed ID | 34969180 |
SCOPUSEID | 2-s2.0-85122672005 |
通讯作者地址 | [Deng, Junjie]Department of Orthopaedics,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China |
Scopus学科分类 | Biomaterials;Biomedical Engineering;Pharmaceutical Science |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/8605 |
专题 | 第二临床医学院、附属第二医院、育英儿童医院 附属第二医院_骨科重点学科实验室 |
通讯作者 | Deng, Junjie |
作者单位 | 1.Department of Orthopaedics,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 2.Key Laboratory of Orthopaedics of Zhejiang Province,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 3.Wenzhou Institute,University of Chinese Academy Sciences,Zhejiang,Wenzhou,325000,China; 4.Drexel University,Philadelphia,19104,United States |
第一作者单位 | 第二临床医学院,附属第二医院、育英儿童医院; 附属第二医院; 温州医科大学 |
通讯作者单位 | 第二临床医学院,附属第二医院、育英儿童医院; 附属第二医院 |
第一作者的第一单位 | 第二临床医学院,附属第二医院、育英儿童医院 |
推荐引用方式 GB/T 7714 | Pan, Xiaoyun,Yuan, Shanshan,Xun, Xiaojie,et al. Long-Term Recruitment of Endogenous M2 Macrophages by Platelet Lysate-Rich Plasma Macroporous Hydrogel Scaffold for Articular Cartilage Defect Repair[J]. ADVANCED HEALTHCARE MATERIALS,2022,11(6):e2101661.. |
APA | Pan, Xiaoyun., Yuan, Shanshan., Xun, Xiaojie., Fan, Zhiyuan., Xue, Xinghe., ... & Deng, Junjie. (2022). Long-Term Recruitment of Endogenous M2 Macrophages by Platelet Lysate-Rich Plasma Macroporous Hydrogel Scaffold for Articular Cartilage Defect Repair. ADVANCED HEALTHCARE MATERIALS, 11(6), e2101661.. |
MLA | Pan, Xiaoyun,et al."Long-Term Recruitment of Endogenous M2 Macrophages by Platelet Lysate-Rich Plasma Macroporous Hydrogel Scaffold for Articular Cartilage Defect Repair".ADVANCED HEALTHCARE MATERIALS 11.6(2022):e2101661.. |
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