科研成果详情

题名Long-Term Recruitment of Endogenous M2 Macrophages by Platelet Lysate-Rich Plasma Macroporous Hydrogel Scaffold for Articular Cartilage Defect Repair
作者
发表日期2022-03
发表期刊ADVANCED HEALTHCARE MATERIALS   影响因子和分区
语种英语
原始文献类型Article ; Early Access
关键词cartilage repair endogenous M2 macrophages long-term recruitment macroporous hydrogel scaffolds platelet lysate-rich plasma
其他关键词MESENCHYMAL STEM-CELLS ; POLARIZATION ; INFLAMMATION ; REGENERATION ; MECHANISMS ; PHENOTYPE ; DELIVERY ; COLLAGEN
摘要After cartilage damage, a large number of monocytes/macrophages infiltrate into adjacent synovium and the resident macrophages in synovial tissue transform to activated macrophages (M1), which secrete pro-inflammatory cytokines to induce sustained inflammation and chondrocyte apoptotic. However, current clinical therapies for cartilage repair can rarely achieve long-term anti-inflammatory regulation and satisfactory outcomes. Herein, a platelet lysate-rich plasma macroporous hydrogel (PLPMH) scaffold with around 100 mu m pore size and 1.25 MPa Young's modulus is developed to sustainedly recruit and polarize endogenous anti-inflammatory macrophages (M2) for improving cartilage defect repair. PLPMH scaffold can steadily release sphingosine1-phosphate and proteins via gradual degradation, thus inducing M2 macrophages migration or resting (M0) macrophages migration and then polarization to M2 phenotype, and improving the secretion of anti-inflammatory cytokines. Furthermore, PLPMH scaffold exhibits negligible inflammatory responses in vivo and promotes endogenous M2 macrophage infiltration in large numbers and long-time duration to provide a local anti-inflammatory microenvironment, which even lasts for 42 d. In a rabbit model of cartilage defect, PLPMH scaffold increases the ratio of M2 macrophages and improves cartilage tissue regeneration. These studies support that PLPMH scaffold may have a great potential in articular cartilage tissue engineering by providing an anti-inflammatory and pro-regenerative microenvironment.
资助项目National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31971260]; Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholar [LR20C100001]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LY19C100002, LY21H060008]; Key Laboratory of Orthopaedics of Zhejiang Province [ZJGK1804Y]; Wenzhou Scientific Research Project [Y20190136]; Wenzhou Institute, University of Chinese Academy of Sciences [WIUCASQD2019004]
出版者WILEY
出版地HOBOKEN
ISSN2192-2640
EISSN2192-2659
卷号11期号:6页码:e2101661.
DOI10.1002/adhm.202101661
页数55
WOS类目Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS研究方向Engineering ; Science & Technology - Other Topics ; Materials Science
WOS记录号WOS:000739897400001
收录类别SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号20220311466876
EI主题词Macrophages
EI分类号461.1 Biomedical Engineering ; 461.2 Biological Materials and Tissue Engineering ; 461.9 Biology ; 461.9.1 Immunology ; 801.3 Colloid Chemistry ; 804 Chemical Products Generally ; 913.5 Maintenance ; 931.2 Physical Properties of Gases, Liquids and Solids ; 951 Materials Science
URL查看原文
PubMed ID34969180
SCOPUSEID2-s2.0-85122672005
通讯作者地址[Deng, Junjie]Department of Orthopaedics,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China
Scopus学科分类Biomaterials;Biomedical Engineering;Pharmaceutical Science
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/8605
专题第二临床医学院、附属第二医院、育英儿童医院
附属第二医院_骨科重点学科实验室
通讯作者Deng, Junjie
作者单位
1.Department of Orthopaedics,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China;
2.Key Laboratory of Orthopaedics of Zhejiang Province,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China;
3.Wenzhou Institute,University of Chinese Academy Sciences,Zhejiang,Wenzhou,325000,China;
4.Drexel University,Philadelphia,19104,United States
第一作者单位第二临床医学院,附属第二医院、育英儿童医院;  附属第二医院;  温州医科大学
通讯作者单位第二临床医学院,附属第二医院、育英儿童医院;  附属第二医院
第一作者的第一单位第二临床医学院,附属第二医院、育英儿童医院
推荐引用方式
GB/T 7714
Pan, Xiaoyun,Yuan, Shanshan,Xun, Xiaojie,et al. Long-Term Recruitment of Endogenous M2 Macrophages by Platelet Lysate-Rich Plasma Macroporous Hydrogel Scaffold for Articular Cartilage Defect Repair[J]. ADVANCED HEALTHCARE MATERIALS,2022,11(6):e2101661..
APA Pan, Xiaoyun., Yuan, Shanshan., Xun, Xiaojie., Fan, Zhiyuan., Xue, Xinghe., ... & Deng, Junjie. (2022). Long-Term Recruitment of Endogenous M2 Macrophages by Platelet Lysate-Rich Plasma Macroporous Hydrogel Scaffold for Articular Cartilage Defect Repair. ADVANCED HEALTHCARE MATERIALS, 11(6), e2101661..
MLA Pan, Xiaoyun,et al."Long-Term Recruitment of Endogenous M2 Macrophages by Platelet Lysate-Rich Plasma Macroporous Hydrogel Scaffold for Articular Cartilage Defect Repair".ADVANCED HEALTHCARE MATERIALS 11.6(2022):e2101661..

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