Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery

doi:10.3390/cancers12102837

科研成果详情

题名	Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery
作者	Kou, Longfa1,2; Yao, Qing2,3; Zhang, Hailin2,4; Chu, Maoping2,5; Bhutia, Yangzom D.6; Chen, Ruijie1,2; Ganapathy, Vadivel 1,2,6
发表日期	2020-10
发表期刊	CANCERS 影响因子和分区
语种	英语
原始文献类型	Review
关键词	plasma membrane transporters nano-drug delivery systems targeted drug delivery oral absorption site-specific drug delivery
其他关键词	POLY(ETHYLENE GLYCOL)-CO-POLY(TRIMETHYLENE CARBONATE) ; MOLECULAR-WEIGHT HEPARIN ; BLOOD-BRAIN-BARRIER ; ORAL DELIVERY ; L-CARNITINE ; DEOXYCHOLIC-ACID ; MODIFIED NANOPARTICLES ; GLUCOSE TRANSPORTERS ; PEPTIDE TRANSPORTERS ; CANCER-CELLS
摘要	Simple Summary Nano-drug delivery systems serve as Trojan horses to carry therapeutic drugs as cargos and deliver them to target cells. The specificity of these delivery vehicles to a particular cell type can be improved if the surface of the vehicles is chemically modified in such a manner that they are recognized and attracted to the target cell. This can be accomplished if the target cell selectively expresses a receptor or transporter and the surface of the drug-delivery vehicles is conjugated with the receptor agonist or the transporter substrate. In this review, we detail published literature on the successful exploitation of plasma membrane transporters for this purpose. In particular, this review emphasizes the delivery of chemotherapeutic drugs to cancer cells by targeting the nano-delivery systems specifically to certain transporters that are selectively upregulated in cancer cells. Nano-devices are recognized as increasingly attractive to deliver therapeutics to target cells. The specificity of this approach can be improved by modifying the surface of the delivery vehicles such that they are recognized by the target cells. In the past, cell-surface receptors were exploited for this purpose, but plasma membrane transporters also hold similar potential. Selective transporters are often highly expressed in biological barriers (e.g., intestinal barrier, blood-brain barrier, and blood-retinal barrier) in a site-specific manner, and play a key role in the vectorial transfer of nutrients. Similarly, selective transporters are also overexpressed in the plasma membrane of specific cell types under pathological states to meet the biological needs demanded by such conditions. Nano-drug delivery systems could be strategically modified to make them recognizable by these transporters to enhance the transfer of drugs across the biological barriers or to selectively expose specific cell types to therapeutic drugs. Here, we provide a comprehensive review and detailed evaluation of the recent advances in the field of transporter-targeted nano-drug delivery systems. We specifically focus on areas related to intestinal absorption, transfer across blood-brain barrier, tumor-cell selective targeting, ocular drug delivery, identification of the transporters appropriate for this purpose, and details of the rationale for the approach.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81803443, 81903551]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LQ19H300001]; Wenzhou Science and Technology Bureau [ZY2019007, Y20180180, Y20180208, Y20190177]; Special Project for Significant New Drug Research and Development in the Major National Science and Technology Projects of China [2020ZX09201002]
出版者	MDPI
出版地	BASEL
ISSN	2072-6694
EISSN	2072-6694
卷号	12 期号:10 页码:2837
DOI	10.3390/cancers12102837
页数	27
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000584594600001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33019627
PMC记录号	PMC7599460
SCOPUSEID	2-s2.0-85091907671
通讯作者地址	[Chen, Ruijie]Department of Pharmacy,the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Zhejiang,325027,China ; [Chen, Ruijie]Wenzhou Municipal Key Laboratory of Pediatric Pharmacy,Zhejiang,325027,China ; [Ganapathy, Vadivel]Department of Pharmacy,the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Zhejiang,325027,China ; [Ganapathy, Vadivel]Wenzhou Municipal Key Laboratory of Pediatric Pharmacy,Zhejiang,325027,China ; [Ganapathy, Vadivel]Department of Cell Biology and Biochemistry,Texas Tech University Health Sciences Center,Lubbock,79430,United States
Scopus学科分类	Oncology;Cancer Research
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8575
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院药学院（分析测试中心）_药学系
通讯作者	Chen, Ruijie; Ganapathy, Vadivel
作者单位	1.Department of Pharmacy,the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Zhejiang,325027,China; 2.Wenzhou Municipal Key Laboratory of Pediatric Pharmacy,Zhejiang,325027,China; 3.Department of Pharmaceutical Sciences,Wenzhou Medical University,Zhejiang,325035,China; 4.Department of Children’s Respiration Disease,the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Zhejiang,325027,China; 5.Pediatric Research Institute,the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Zhejiang,325027,China; 6.Department of Cell Biology and Biochemistry,Texas Tech University Health Sciences Center,Lubbock,79430,United States
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Kou, Longfa,Yao, Qing,Zhang, Hailin,et al. Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery[J]. CANCERS,2020,12(10):2837.
APA	Kou, Longfa., Yao, Qing., Zhang, Hailin., Chu, Maoping., Bhutia, Yangzom D.., ... & Ganapathy, Vadivel. (2020). Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery. CANCERS, 12(10), 2837.
MLA	Kou, Longfa,et al."Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery".CANCERS 12.10(2020):2837.