Loss of FGF21 in diabetic mouse during hepatocellular carcinogenetic transformation

科研成果详情

题名	Loss of FGF21 in diabetic mouse during hepatocellular carcinogenetic transformation
作者	Zhang, Quan 1,3; Li, Yan 2; Liang, Tingting 1,3; Lu, Xuemian3; Liu, Xingkai 4; Zhang, Chi 3; Jiang, Xin 4; Martin, Robert C.2; Cheng, Mingliang 1; Cai, Lu3,5
发表日期	2015-12-31
发表期刊	AMERICAN JOURNAL OF CANCER RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Hepatocellular carcinoma diabetes OVE26 mice dimethylnitrosamine FGF21 dimethylnitrosamine.
其他关键词	GROWTH-FACTOR 21 ; FATTY LIVER-DISEASE ; OXIDATIVE STRESS ; NONALCOHOLIC STEATOHEPATITIS ; EPIDEMIOLOGIC EVIDENCE ; INSULIN-RESISTANCE ; HEPATIC STEATOSIS ; TRANSGENIC MICE ; UNITED-STATES ; CARCINOMA
摘要	Diabetes associated metabolic syndrome has been shown to be an independent risk factor for the development of hepatocellular carcinoma (HCC). Cirrhosis, in fact, was not always a prerequisite of HCC development and this might particularly apply to the metabolic abnormality associated HCC. This study was to investigate diabetes associated HCC and the potential role of FGF21 during carcinogenetic transformation of HCC. Dimethylnitrosamine (DEN) was used to induce HCC in the diabetic OVE26 mice. Pronounced damage characterized by steatohepatitis was found in the liver of diabetic mice. Steatohepatitis accompanied by constant cell proliferation and tumor cell growth were also found in the hepatic tissues of diabetic OVE26 mice when DEN being administrated. FGF21 protein level increased in liver tissues at an early stage along with steatohepatitis in diabetic OVE26 mice, but decreased in liver tissues later when HCC was developed. In addition, decreased FGF21 protein level was associated with cancerous hyper-proliferation and aberrant p53 and TGF-beta/Smad signaling during HCC development. Loss of FGF21 may play an important role in HCC carcinogenetic transformation during metabolic liver injury in diabetic animals. The present finding calls attention to the need to control metabolic disorders associated with diabetes and may further develop a protective strategy against HCC.
资助项目	American Diabetes Association Basic Science AwardAmerican Diabetes Association [1-13-BS-109]; Natural Science Foundation of Guizhou Educational Department [2011037]
出版者	E-CENTURY PUBLISHING CORP
出版地	MADISON
ISSN	2156-6976
卷号	5 期号:5 页码:1762-1774
页数	13
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000358364200016
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	26175944
PMC记录号	PMC4497442
SCOPUSEID	2-s2.0-85006213847
通讯作者地址	[Cheng, Mingliang]Department of Infectious Diseases,Affiliated Hospital,Guiyang Medical College,Guiyang, Guizhou,550004,China
Scopus学科分类	Oncology;Cancer Research
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8555
专题	温州医科大学
通讯作者	Cheng, Mingliang
作者单位	1.Department of Infectious Diseases,Affiliated Hospital,Guiyang Medical College,Guiyang, Guizhou,550004,China; 2.Department of Surgery,School of Medicine,University of Louisville,Louisville,40202,United States; 3.Chinese-American Research Institute for Diabetic Complications Ruian Center,Department of Endocrinology,The Third Affifiliated Hospital,Wenzhou Medical University,Ruian, Zhejiang,325200,China; 4.The First Hospital,Jilin University,Changchun,130021,China; 5.Kosair Children's Hospital Research Institute,The Department of Pediatrics,University of Louisville,Louisville,40202,United States
第一作者单位	温州医科大学
推荐引用方式 GB/T 7714	Zhang, Quan,Li, Yan,Liang, Tingting,et al. Loss of FGF21 in diabetic mouse during hepatocellular carcinogenetic transformation[J]. AMERICAN JOURNAL OF CANCER RESEARCH,2015,5(5):1762-1774.
APA	Zhang, Quan., Li, Yan., Liang, Tingting., Lu, Xuemian., Liu, Xingkai., ... & Cai, Lu. (2015). Loss of FGF21 in diabetic mouse during hepatocellular carcinogenetic transformation. AMERICAN JOURNAL OF CANCER RESEARCH, 5(5), 1762-1774.
MLA	Zhang, Quan,et al."Loss of FGF21 in diabetic mouse during hepatocellular carcinogenetic transformation".AMERICAN JOURNAL OF CANCER RESEARCH 5.5(2015):1762-1774.