Using acoustic cavitation to enhance chemotherapy of DOX liposomes: experiment in vitro and in vivo

doi:10.3109/03639045.2011.640332

科研成果详情

题名	Using acoustic cavitation to enhance chemotherapy of DOX liposomes: experiment in vitro and in vivo
作者	Zhao, Ying-Zheng1; Dai, Dan-Dan 1; Lu, Cui-Tao1; Lv, Hai-Feng 1; Zhang, Yan 2; Li, Xing 1; Li, Wen-Feng3; Wu, Yan 4; Jiang, Lei3; Li, Xiao-Kun1; Huang, Pin-Tong5,6; Chen, Li-Juan1; Lin, Min 1
发表日期	2012-09
发表期刊	DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Chemotherapy liposome acoustic cavitation phospholipid-based microbubbles doxorubicin
其他关键词	ULTRASOUND-TRIGGERED RELEASE ; CONTRAST AGENT ; DRUG-DELIVERY ; MICROBUBBLES ; ENCAPSULATION ; PROTEIN
摘要	Experiments in vitro and in vivo were designed to investigate tumor growth inhibition of chemotherapeutics-loaded liposomes enhanced by acoustic cavitation. Doxorubicin-loaded liposomes (DOX liposomes) were used in experiments to investigate acoustic cavitation mediated effects on cell viability and chemotherapeutic function. The influence of lingering sensitive period after acoustic cavitation on tumor inhibition was also investigated. Animal experiment was carried out to verify the practicability of this technique in vivo. From experiment results, blank phospholipid-based microbubbles (PBM) combined with ultrasound (US) at intensity below 0.3 W/cm(2) could produce acoustic cavitation which maintained cell viability at high level. Compared with DOX solution, DOX liposomes combined with acoustic cavitation exerted effective tumor inhibition in vitro and in vivo. The lingering sensitive period after acoustic cavitation could also enhance the susceptibility of tumor to chemotherapeutic drugs. DOX liposomes could also exert certain tumor inhibition under preliminary acoustic cavitation. Acoustic cavitation could enhance the absorption efficiency of DOX liposomes, which could be used to reduce DOX adverse effect on normal organs in clinical chemotherapy.
资助项目	National Natural Science FundsNational Natural Science Foundation of China (NSFC) [30870755, 81071277, 81071164]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [Y2110587, Y2080915]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7112100]; Scientific Research Joint Funds of Health Ministry and Zhejiang Province [WKJ2011-2-010]; Medicine and Health Grant from Wenzhou Bureau of Science and Technology [S20100049, H20100017, Y20100029]; Zhejiang Province funds for Health Department [2010ZQ007, 2011ZDA017]; Zhejiang Province funds for Education Department [Y201016664]
出版者	TAYLOR & FRANCIS LTD
出版地	ABINGDON
ISSN	0363-9045
EISSN	1520-5762
卷号	38 期号:9 页码:1090-1098
DOI	10.3109/03639045.2011.640332
页数	9
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000306849900009
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	22188116
SCOPUSEID	2-s2.0-84864420434
通讯作者地址	[Li, Wen-Feng]Oncology Department,First Affiliated Hospital,Wenzhou Medical College,China
Scopus学科分类	Pharmacology;Pharmaceutical Science;Drug Discovery;Organic Chemistry
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8478
专题	附属第一医院附属第二医院第二临床医学院、附属第二医院、育英儿童医院第二临床医学院、附属第二医院、育英儿童医院_影像医学与核医学_超声科
通讯作者	Li, Wen-Feng
作者单位	1.Wenzhou Medical College,China; 2.Department of Ultrasound,Chinese PLA 307 Hospital,China; 3.Oncology Department,First Affiliated Hospital,Wenzhou Medical College,China; 4.Department of Pharmacy,Air Force General Hospital, Beijing,China; 5.Ultrasound Department,Second Affiliated Hospital,Wenzhou Medical College,China; 6.Ultrasound Department,Zhejiang University,Second Affiliated Hospital,China
第一作者单位	温州医科大学
通讯作者单位	附属第一医院
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Zhao, Ying-Zheng,Dai, Dan-Dan,Lu, Cui-Tao,et al. Using acoustic cavitation to enhance chemotherapy of DOX liposomes: experiment in vitro and in vivo[J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,2012,38(9):1090-1098.
APA	Zhao, Ying-Zheng., Dai, Dan-Dan., Lu, Cui-Tao., Lv, Hai-Feng., Zhang, Yan., ... & Lin, Min. (2012). Using acoustic cavitation to enhance chemotherapy of DOX liposomes: experiment in vitro and in vivo. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 38(9), 1090-1098.
MLA	Zhao, Ying-Zheng,et al."Using acoustic cavitation to enhance chemotherapy of DOX liposomes: experiment in vitro and in vivo".DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 38.9(2012):1090-1098.