Preventive effect of non-mitogenic acidic fibroblast growth factor on diabetes-induced testicular cell death

doi:10.1016/j.reprotox.2014.08.002

科研成果详情

题名	Preventive effect of non-mitogenic acidic fibroblast growth factor on diabetes-induced testicular cell death
作者	Skibba, Melissa 1; Zhang, Chi 2,3; Jiang, Xin 4,5; Xin, Ying 5,6; Cai, Lu1,2,5
发表日期	2014-11
发表期刊	REPRODUCTIVE TOXICOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	FGF-1 Germ cell apoptosis Type 1 diabetes Diabetic infertility Testicular effect
其他关键词	ENDOPLASMIC-RETICULUM STRESS ; CYTOCHROME-C RELEASE ; INDUCED APOPTOSIS ; OXIDATIVE STRESS ; MITOCHONDRIAL ; ACTIVATION ; EXPRESSION ; CASPASE-12 ; CLEAVAGE ; PATHWAY
摘要	Fibroblast growth factor (FGF)-1 was found to protect the heart from oxidative damage, but clinically its long-term use was restricted for its undesirable proliferating activity on cells. Thus a cluster of amino acids responsible for the proliferation were deleted in the native FGF-1 to create a non-mitogenic FGF-1 (nmFGF-1). Whether the nmFGF-1 protects male germ cells from diabetes-induced apoptotic death was examined in diabetic mice induced with multiple low-doses of streptozotocin, followed by nmFGF-1 treatment for 6 months. Diabetic mice showed a decrease in testicular weight and an increase in apoptotic cell death. Treatment with nmFGF-1 alleviated the diabetic effects on testicular weight and apoptotic cell death. Mechanistically, nmFGF-1 may alleviate diabetes-induced germ cell death by decreasing the BAX/Bcl-2 ratio and endoplasmic reticulum stress as well as associated cell death, which is associated with Nrf-2 activation. (C) 2014 Elsevier Inc. All rights reserved.
资助项目	Basic Research Award from American Diabetes Association [1-11-BA-17]
出版者	PERGAMON-ELSEVIER SCIENCE LTD
出版地	OXFORD
ISSN	0890-6238
EISSN	1873-1708
卷号	49 页码:136-144
DOI	10.1016/j.reprotox.2014.08.002
页数	9
WOS类目	Reproductive Biology ; Toxicology
WOS研究方向	Reproductive Biology ; Toxicology
WOS记录号	WOS:000345257900014
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	25150137
SCOPUSEID	2-s2.0-84907300711
通讯作者地址	[Cai, Lu]Kosair Children's Hospital Research Institute,570 South Preston Street, Baxter I, Suite 304F,United States
Scopus学科分类	Toxicology
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8434
专题	药学院（分析测试中心）药学院（分析测试中心）_生物制药系_生物制药工程
通讯作者	Cai, Lu
作者单位	1.Department of Pharmacology and Toxicology, The University of Louisville,United States; 2.The Chinese-American Research Institute for Diabetic Complications, School of Pharmaceutical Sciences and Key Laboratory of Biotechnology Pharmaceutical Engineering, Wenzhou Medical University,China; 3.The Chinese-American Research Institute for Diabetic Complications, The RuiAn Center of Wenzhou Medical University,China; 4.Department of Radiation Oncology of the First Hospital of Jilin University,China; 5.KCHRI at the Department of Pediatrics, The University of Louisville,United States; 6.Key Laboratory of Pathobiology, Ministry of Education, Jilin University,China
推荐引用方式 GB/T 7714	Skibba, Melissa,Zhang, Chi,Jiang, Xin,et al. Preventive effect of non-mitogenic acidic fibroblast growth factor on diabetes-induced testicular cell death[J]. REPRODUCTIVE TOXICOLOGY,2014,49:136-144.
APA	Skibba, Melissa, Zhang, Chi, Jiang, Xin, Xin, Ying, & Cai, Lu. (2014). Preventive effect of non-mitogenic acidic fibroblast growth factor on diabetes-induced testicular cell death. REPRODUCTIVE TOXICOLOGY, 49, 136-144.
MLA	Skibba, Melissa,et al."Preventive effect of non-mitogenic acidic fibroblast growth factor on diabetes-induced testicular cell death".REPRODUCTIVE TOXICOLOGY 49(2014):136-144.