LC-Q-TOF-MS Characterization of Polyphenols from White Bayberry Fruit and Its Antidiabetic Effect in KK-A(y) Mice

doi:10.1021/acsomega.0c02759

科研成果详情

题名	LC-Q-TOF-MS Characterization of Polyphenols from White Bayberry Fruit and Its Antidiabetic Effect in KK-A(y) Mice
作者	Liu, Yilong 1; Zhang, Xianan 2; Zhan, Liuhuan 1; Xu, Chang 1; Sun, Linxiao3; Jiang, Huamin 4; Sun, Chongde 1; Li, Xian 1
发表日期	2020-07-21
发表期刊	ACS OMEGA 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	MYRICA-RUBRA SIEB. ; GLUCOSE CONSUMPTION ; DIABETES-MELLITUS ; OXIDATIVE STRESS ; PULP EXTRACTS ; INSULIN ; MULBERRY ; ZUCC. ; RISK ; CYANIDIN-3-O-GLUCOSIDE
摘要	The present study is to investigate the polyphenolic composition and in vivo antidiabetic effect of white-fleshed Chinese bayberry cultivar Shui Jing. By liquid chromatography quadrupole time-of-flight mass spectrometry (LC-TOF- MS), 38 polyphenols were identified in the Shui Jing fruit extract (SJE), where proanthocyanidins (PAs), including epigallocatechin gallate (EGCG), as well as flavonols, including myricitrin and quercetrin, were the predominant ingredients. After a 5-week experiment, the SJE (200 mg/kg bodyweight) significantly reduced fasting blood glucose, elevated glucose tolerance, and insulin sensitivity in diabetic KK-A(y) mice. It markedly attenuated bodyweight gain and decreased glycolipid metabolism-related markers including insulin, leptin, glucagon, triglyceride (TG), total cholesterol (TC), lowdensity lipoprotein cholesterol (LDL-c) and alanine aminotransferase (ALT) levels in mice. Liver weight and hepatic lipid accumulation were also significantly reduced by the SJE. Gene expressions of insulin 1 (INS1) and glycogen synthase kinase 3 beta (GSK3b) were markedly inhibited while the hepatic phosphorylation of AMPK alpha was significantly increased in the liver of SJE-treated mice, indicating that the SJE may exert an antidiabetic effect through an AMPK-dependent pathway. In conclusion, white bayberry rich in PAs and flavonols may have great potential in the regulation of diabetes mellitus.
资助项目	National Key R&D Program of China [2017YFE0102200]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31872067]; 111 ProjectMinistry of Education, China - 111 Project [B17039]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities
出版者	AMER CHEMICAL SOC
出版地	WASHINGTON
ISSN	2470-1343
卷号	5 期号:28 页码:17839-17849
DOI	10.1021/acsomega.0c02759
页数	11
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
WOS记录号	WOS:000554991800088
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	32715269
PMC记录号	PMC7377368
Scopus记录号	2-s2.0-85088573175
通讯作者地址	[Li, Xian]Zhejiang Univ, Zhejiang Prov Key Lab Hort Plant Integrat Biol St, State Agr Minist, Lab Hort Plant Growth Dev & Qual Improvement, Hangzhou 310058, Peoples R China.
scopus学科分类	Chemistry (all);Chemical Engineering (all)
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8321
专题	第一临床医学院（信息与工程学院）、附属第一医院_浙江省胰脏肝脏危重性疾病重点实验室附属第一医院
通讯作者	Li, Xian
作者单位	1.Zhejiang Univ, Zhejiang Prov Key Lab Hort Plant Integrat Biol St, State Agr Minist, Lab Hort Plant Growth Dev & Qual Improvement, Hangzhou 310058, Peoples R China; 2.Shanghai Acad Agr Sci, Forestry & Fruit Res Inst, Shanghai 201403, Peoples R China; 3.Wenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Di, Zhejiang Prov Top Key Discipline Surg, Affiliated Hosp 1, Wenzhou 325000, Peoples R China; 4.Hangzhou Lichuan Ecol Agr Dev Co Ltd, Hangzhou 311123, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yilong,Zhang, Xianan,Zhan, Liuhuan,et al. LC-Q-TOF-MS Characterization of Polyphenols from White Bayberry Fruit and Its Antidiabetic Effect in KK-A(y) Mice[J]. ACS OMEGA,2020,5(28):17839-17849.
APA	Liu, Yilong., Zhang, Xianan., Zhan, Liuhuan., Xu, Chang., Sun, Linxiao., ... & Li, Xian. (2020). LC-Q-TOF-MS Characterization of Polyphenols from White Bayberry Fruit and Its Antidiabetic Effect in KK-A(y) Mice. ACS OMEGA, 5(28), 17839-17849.
MLA	Liu, Yilong,et al."LC-Q-TOF-MS Characterization of Polyphenols from White Bayberry Fruit and Its Antidiabetic Effect in KK-A(y) Mice".ACS OMEGA 5.28(2020):17839-17849.