Predicting the Value of Adjuvant Therapy in Esophageal Squamous Cell Carcinoma by Combining the Total Number of Examined Lymph Nodes with the Positive Lymph Node Ratio

doi:10.1245/s10434-019-07489-3

科研成果详情

题名	Predicting the Value of Adjuvant Therapy in Esophageal Squamous Cell Carcinoma by Combining the Total Number of Examined Lymph Nodes with the Positive Lymph Node Ratio
作者	Li, Yida 1,2; Zhao, Weixin 1,2; Ni, Jianjiao 1,2; Zou, Liqing 1,2; Yang, Xi 1,2; Yu, Weiwei 3; Fu, Xiaolong 4; Zhao, Kuaile 1,2; Zhang, Yawei 2,5; Chen, Haiquan 2,5; Xiang, Jiaqing 2,5; Xie, Congying6; Zhu, Zhengfei 1,2
发表日期	2019-08
发表期刊	ANNALS OF SURGICAL ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	PN CATEGORIES ; SURVIVAL ; CLASSIFICATION ; RADIOTHERAPY ; NEOADJUVANT ; METASTASIS ; RECURRENCE ; REPLACE ; CANCER ; SYSTEM
摘要	BackgroundThe value of adjuvant therapy for esophageal squamous cell carcinoma (ESCC) has been controversial, at least partially due to the lack of efficient criteria for selecting suitable patients. This study aimed to explore the existence of parameters related to lymph node (LN) status that can predict the value of adjuvant therapy in ESCC.MethodsThe study included 298 patients with ESCC who had undergone radical esophagectomy with lymphadenectomy. Adjuvant therapy was defined as reception of adjuvant chemotherapy, radiotherapy, or chemoradiotherapy. For the study, LN ratio (LNR), total number of resected LNs (TLNs), and pN stage were selected for Cox regression analyses, including their correlations and prognostic values for survival. Log-rank tests were used to compare the survival rates of the patients with and without adjuvant therapy stratified by pN stage, TLNs, LNR, or their combinations.ResultsThe independent prognostic factors for survival were TLNs, LNR, and pN stage. Whereas pN stage was significantly related to TLNs and LNR, TLNs were not correlated with LNR. The survival rates between the patients with and those without adjuvant therapy stratified by pN stage, TLNs, or LNR did not differ significantly. We used the median values of TLNs and LNR to group the patients into four groups. The patients in the group with fewer TLNs and higher LNR who had undergone adjuvant therapy showed a significantly better survival than those without adjuvant therapy (p=0.030).ConclusionsIn contrast to TLNs, LNR, and pN stage as single factors, the combination of TLNs and LNR can predict the value of adjuvant therapy.
资助项目	National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872461]; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education MinistryScientific Research Foundation for the Returned Overseas Chinese Scholars; Foundation of Shanghai Municipal Commission of Health and Family Planning [01540211]
出版者	SPRINGER
出版地	NEW YORK
ISSN	1068-9265
EISSN	1534-4681
卷号	26 期号:8 页码:2367-2374
DOI	10.1245/s10434-019-07489-3
页数	8
WOS类目	Oncology ; Surgery
WOS研究方向	Oncology ; Surgery
WOS记录号	WOS:000474357200012
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	31187360
Scopus记录号	2-s2.0-85067404068
通讯作者地址	[Zhu, Zhengfei]Department of Radiation Oncology,Fudan University Shanghai Cancer Center,Shanghai,China
scopus学科分类	Surgery;Oncology
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8293
专题	附属第一医院_放化疗科
通讯作者	Zhu, Zhengfei
作者单位	1.Department of Radiation Oncology,Fudan University Shanghai Cancer Center,Shanghai,China; 2.Department of Oncology,Shanghai Medical College,Fudan University,Shanghai,China; 3.Department of Radiation Oncology,Six Hospital of Jiao Tong University,Shanghai,China; 4.Department of Radiation Oncology,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai,China; 5.Department of Thoracic Surgery,Fudan University Shanghai Cancer Center,Shanghai,China; 6.Radiotherapy and Chemotherapy Department,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
推荐引用方式 GB/T 7714	Li, Yida,Zhao, Weixin,Ni, Jianjiao,et al. Predicting the Value of Adjuvant Therapy in Esophageal Squamous Cell Carcinoma by Combining the Total Number of Examined Lymph Nodes with the Positive Lymph Node Ratio[J]. ANNALS OF SURGICAL ONCOLOGY,2019,26(8):2367-2374.
APA	Li, Yida., Zhao, Weixin., Ni, Jianjiao., Zou, Liqing., Yang, Xi., ... & Zhu, Zhengfei. (2019). Predicting the Value of Adjuvant Therapy in Esophageal Squamous Cell Carcinoma by Combining the Total Number of Examined Lymph Nodes with the Positive Lymph Node Ratio. ANNALS OF SURGICAL ONCOLOGY, 26(8), 2367-2374.
MLA	Li, Yida,et al."Predicting the Value of Adjuvant Therapy in Esophageal Squamous Cell Carcinoma by Combining the Total Number of Examined Lymph Nodes with the Positive Lymph Node Ratio".ANNALS OF SURGICAL ONCOLOGY 26.8(2019):2367-2374.