Low-dose radiation induces renal SOD1 expression and activity in type 1 diabetic mice

doi:10.3109/09553002.2014.877174

科研成果详情

题名	Low-dose radiation induces renal SOD1 expression and activity in type 1 diabetic mice
作者	Zhang, Chi 1,2; Xing, Xiao 2,3; Zhang, Fangfang 1,2; Shao, Minglong1,2,3; Jin, Shuzi 3; Yang, Hong1; Wang, Guanjun 4; Cui, Jiuwei 4; Cai, Lu1,2,5; Li, Wei 4; Lu, Xuemian1
发表日期	2014-03
发表期刊	INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Low-dose radiation SOD1 diabetic nephropathy
其他关键词	SUPEROXIDE-DISMUTASE ; ANTIOXIDANT ENZYMES ; OXIDATIVE STRESS ; NITRIC-OXIDE ; GENE-EXPRESSION ; NEPHROPATHY ; CELLS ; ATTENUATION ; MODULATION ; INJURY
摘要	Purpose: Oxidative stress plays a critical role in the pathogenesis of diabetic nephropathy (DN). As an antioxidant, superoxide dismutase (SOD)-1 deficiency exacerbates but SOD1 supplementation prevents diabetes-induced renal damage. Previously, we have demonstrated that repetitive exposure to low-dose radiation (LDR) at 25 mGy significantly prevents DN. Whether this prevention is related to SOD1 expression and activity remains unknown. The aim of the present study was to explore the effects of different methods of LDR treatment on SOD1 expression and activity in the kidneys of diabetic mice. Materials and methods: C57BL/6J mice were induced with type 1 diabetes using streptozotocin (STZ). Diabetic mice were irradiated with whole-body X-rays at either a single dose of 25 mGy or 75 mGy, or three doses of 25 mGy and then sacrificed at different times. Body weight, blood glucose level, and renal SOD1 expression and activity were measured. Results: LDR had no impact on the body weights or blood glucose levels of the mice in either the normal or diabetic groups. A single exposure of LDR at 25 mGy did not preserve renal SOD1 expression and activity in diabetic mice, but a single exposure of LDR at 75 mGy or three exposures of LDR at 25 mGy could preserve them. Conclusion: The stimulation of renal SOD1 expression and activity by a single or cumulative LDR of 75 mGy may be one of the preventive mechanisms of DN observed in the previous study.
资助项目	National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81000294, 81370917, 81071920]; Research and Development Foundation of Wenzhou Medical University [QTJ13005]; Ministry of Education Key Project of Science and Technology [311015]; Zhejiang Provincial Natural Science FoundationNatural Science Foundation of Zhejiang Province [R2090550]
出版者	TAYLOR & FRANCIS LTD
出版地	ABINGDON
ISSN	0955-3002
EISSN	1362-3095
卷号	90 期号:3 页码:224-230
DOI	10.3109/09553002.2014.877174
页数	7
WOS类目	Biology ; Nuclear Science & Technology ; Radiology, Nuclear Medicine & Medical Imaging
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Nuclear Science & Technology ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000332797500003
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	24397406
SCOPUSEID	2-s2.0-84896776514
通讯作者地址	[Li, Wei]Cancer Center of the First Hospital,Jilin University,China
Scopus学科分类	Radiological and Ultrasound Technology;Radiology, Nuclear Medicine and Imaging
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8183
专题	其他_附属第三医院（瑞安市人民医院）温州医科大学
通讯作者	Li, Wei
作者单位	1.Ruian Center of the Chinese-American Research Institute for Diabetic Complications,Wenzhou Medical College,Third Affiliated Hospital,China; 2.Chinese-American Research Institute for Diabetic Complications,Wenzhou Medical College,China; 3.School of Public Health,Jilin University,China; 4.Cancer Center of the First Hospital,Jilin University,China; 5.Kosair Children's Hospital Research Institute,Department of Pediatrics,University of Louisville,United States
第一作者单位	其他_附属第三医院（瑞安市人民医院）; 温州医科大学
第一作者的第一单位	其他_附属第三医院（瑞安市人民医院）
推荐引用方式 GB/T 7714	Zhang, Chi,Xing, Xiao,Zhang, Fangfang,et al. Low-dose radiation induces renal SOD1 expression and activity in type 1 diabetic mice[J]. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY,2014,90(3):224-230.
APA	Zhang, Chi., Xing, Xiao., Zhang, Fangfang., Shao, Minglong., Jin, Shuzi., ... & Lu, Xuemian. (2014). Low-dose radiation induces renal SOD1 expression and activity in type 1 diabetic mice. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 90(3), 224-230.
MLA	Zhang, Chi,et al."Low-dose radiation induces renal SOD1 expression and activity in type 1 diabetic mice".INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 90.3(2014):224-230.