Potential Roles of Dental Pulp Stem Cells in Neural Regeneration and Repair

doi:10.1155/2018/1731289

科研成果详情

题名	Potential Roles of Dental Pulp Stem Cells in Neural Regeneration and Repair
作者	Luo, Lihua1; He, Yan 1,2; Wang, Xiaoyan1; Key, Brian 3; Lee, Bae Hoon 4,5,6; Li, Huaqiong4,5,6; Ye, Qingsong1,2
发表日期	2018-12-31
发表期刊	STEM CELLS INTERNATIONAL 影响因子和分区
语种	英语
原始文献类型	Review
其他关键词	SPINAL-CORD-INJURY ; SCIATIC-NERVE REGENERATION ; MESENCHYMAL STROMAL CELLS ; RETINAL GANGLION-CELLS ; SIDE POPULATION CELLS ; HUMAN BONE-MARROW ; FUNCTIONAL RECOVERY ; IN-VITRO ; NEUROGENIC DIFFERENTIATION ; UMBILICAL-CORD
摘要	This review summarizes current advances in dental pulp stem cells (DPSCs) and their potential applications in the nervous diseases. Injured adult mammalian nervous system has a limited regenerative capacity due to an insufficient pool of precursor cells in both central and peripheral nervous systems. Nerve growth is also constrained by inhibitory factors (associated with central myelin) and barrier tissues (glial scarring). Stem cells, possessing the capacity of self-renewal and multicellular differentiation, promise new therapeutic strategies for overcoming these impediments to neural regeneration. Dental pulp stem cells (DPSCs) derive from a cranial neural crest lineage, retain a remarkable potential for neuronal differentiation, and additionally express multiple factors that are suitable for neuronal and axonal regeneration. DPSCs can also express immunomodulatory factors that stimulate formation of blood vessels and enhance regeneration and repair of injured nerve. These unique properties together with their ready accessibility make DPSCs an attractive cell source for tissue engineering in injured and diseased nervous systems. In this review, we interrogate the neuronal differentiation potential as well as the neuroprotective, neurotrophic, angiogenic, and immunomodulatory properties of DPSCs and its application in the injured nervous system. Taken together, DPSCs are an ideal stem cell resource for therapeutic approaches to neural repair and regeneration in nerve diseases.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81601626]; UQDVCR [610709]; Wenzhou Medical University [QTJ16026]; Research and Development Program Project of Xiangyang [20270268020]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	1687-966X
EISSN	1687-9678
卷号	2018 页码:1731289
DOI	10.1155/2018/1731289
页数	15
WOS类目	Cell & Tissue Engineering
WOS研究方向	Cell Biology
WOS记录号	WOS:000432884000001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29853908
PMC记录号	PMC5964589
SCOPUSEID	2-s2.0-85053395882
通讯作者地址	[Li, Huaqiong]School of Biomedical Engineering,School of Ophthalmology and Optometry and Eye Hospital,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Molecular Biology;Cell Biology
引用统计	被引频次：50[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8160
专题	口腔医学院、附属口腔医院_干细胞与组织工程研究所眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者	Li, Huaqiong
作者单位	1.WMU-UQ Group for Regenerative Medicine,Institute of Stem Cells and Tissue Engineering,School of Stomatology,Wenzhou Medical University,Wenzhou,325035,China; 2.School of Dentistry,University of Queensland,Herston,4006,Australia; 3.School of Biomedical Sciences,University of Queensland,Brisbane,4072,Australia; 4.School of Biomedical Engineering,School of Ophthalmology and Optometry and Eye Hospital,Wenzhou Medical University,Wenzhou,325035,China; 5.Wenzhou Institute of Biomaterials and Engineering,CAS,Wenzhou,325011,China; 6.Eng. Res. Ctr. of Clin. Funct. Materials and Diagnosis and Treatment Devices of Zhejiang Province,Wenzhou Institute of Biomaterials and Engineering,CAS,Wenzhou,325011,China
第一作者单位	口腔医学院、附属口腔医院
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
第一作者的第一单位	口腔医学院、附属口腔医院
推荐引用方式 GB/T 7714	Luo, Lihua,He, Yan,Wang, Xiaoyan,et al. Potential Roles of Dental Pulp Stem Cells in Neural Regeneration and Repair[J]. STEM CELLS INTERNATIONAL,2018,2018:1731289.
APA	Luo, Lihua., He, Yan., Wang, Xiaoyan., Key, Brian., Lee, Bae Hoon., ... & Ye, Qingsong. (2018). Potential Roles of Dental Pulp Stem Cells in Neural Regeneration and Repair. STEM CELLS INTERNATIONAL, 2018, 1731289.
MLA	Luo, Lihua,et al."Potential Roles of Dental Pulp Stem Cells in Neural Regeneration and Repair".STEM CELLS INTERNATIONAL 2018(2018):1731289.