Radiographic Features of Metastatic Brain Tumors from ALK-rearranged Non-small Cell Lung Cancer: Implications for Optimal Treatment Modalities

doi:10.7150/jca.30091

科研成果详情

题名	Radiographic Features of Metastatic Brain Tumors from ALK-rearranged Non-small Cell Lung Cancer: Implications for Optimal Treatment Modalities
作者	Chu, Li 1,8; Ni, Jianjiao 1,8; Yang, Xi 1,8; Tong, Tong 2,8; Wang, Jialei 3,8; Yin, Fang 4; Li, Ruimin 2,8; Li, Yida 1,8; Zou, Liqing 1,8; Li, Yuan 5,8; Xie, Congying6; Li, Guodong 7,8,9; Zhu, Zhengfei 1,8
发表日期	2019
发表期刊	JOURNAL OF CANCER 影响因子和分区
语种	英语
原始文献类型	Article
关键词	lung cancer ALK brain metastases radiographic feature
其他关键词	EDEMA ; RADIOTHERAPY ; CRIZOTINIB ; MENINGIOMAS ; MANAGEMENT ; INHIBITOR ; RADIATION ; THERAPY ; GENE ; CNS
摘要	Purpose: To investigate the radiological features on magnetic resonance imaging (MRI) of brain metastases (BM) from ALK-rearranged non-small cell lung cancer (NSCLC). Patients and Methods: We retrospectively evaluated data from 40 eligible patients with ALK-rearranged NSCLC. Radiographic features of metastatic brain tumors, including the number, size, location, and peritumoral brain edema size (PBES), were delineated using MRI. Results: 13 patients had metachronous BM (MBM), having developed BM at least 6 months after diagnosis with NSCLC. The remaining patients were categorized as having synchronous BM (SBM). Compared with patients in the SBM group, patients in the MBM group were found to have more favorable values for radiological features including BM number, BM size, and PBES. Ten (76.9%) of the 13 patients with MBM had <= 3 lesions and were asymptomatic, and none had developed a diffuse BM pattern, supporting the adoption of stereotactic radiosurgery (SRS) in the majority of these patients and against the administration of prophylactic cranial irradiation (PCI). Conversely, among the 27 patients with SBM, 15 (55.6%) patients had >3 lesions and 12 (44.4%) patients were symptomatic, highlighting the necessity of rapidly administrating brain radiotherapy, either as SRS or whole brain radiotherapy (WBRT). Importantly, only two patients (5.0%) had metastases in the hippocampus and peri-hippocampus region, and both were in the SBM group, indicating the feasibility of hippocampal avoidance WBRT in ALK-rearranged NSCLC. Conclusions: Both WBRT and SRS are appropriate for the treatment of BM in patients with ALK-rearranged NSCLC. The incidence of BM in the hippocampus and peri-hippocampus region is low in our radiological data. Nearly 80% of patients with metachronous BM have oligo-metastatic lesions, indicating that SRS is the preferred therapy while PCI is not indicated.
资助项目	Natural Science Foundation of ShanghaiNatural Science Foundation of Shanghai [19ZR1410400]
出版者	IVYSPRING INT PUBL
出版地	LAKE HAVEN
ISSN	1837-9664
卷号	10 期号:26 页码:6660-6665
DOI	10.7150/jca.30091
页数	6
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000512664800018
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	31777594
PMC记录号	PMC6856904
Scopus记录号	2-s2.0-85075899121
通讯作者地址	[Zhu, Zhengfei]Department of Radiation Oncology,University Shanghai Cancer Center,Shanghai,China
scopus学科分类	Oncology
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8151
专题	附属第一医院_放化疗科
通讯作者	Zhu, Zhengfei
作者单位	1.Department of Radiation Oncology,Fudan University Shanghai Cancer Center,Shanghai,China; 2.Department of Radiology,Fudan University Shanghai Cancer Center,Shanghai,China; 3.Department of Medical Oncology,Fudan University Shanghai Cancer Center,Shanghai,China; 4.Center for Drug Clinical Research,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,China; 5.Department of Pathology,Fudan University Shanghai Cancer Center,Shanghai,China; 6.Radiotherapy and Chemotherapy Department,1st Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 7.Department of Interventional Radiology,Fudan University Shanghai Cancer Center,Shanghai,China; 8.Department of Oncology,Shanghai Medical College,Fudan University,Shanghai,200032,China; 9.Department of Interventional Radiology,Fudan University Shanghai Cancer Center,Shanghai,China
推荐引用方式 GB/T 7714	Chu, Li,Ni, Jianjiao,Yang, Xi,et al. Radiographic Features of Metastatic Brain Tumors from ALK-rearranged Non-small Cell Lung Cancer: Implications for Optimal Treatment Modalities[J]. JOURNAL OF CANCER,2019,10(26):6660-6665.
APA	Chu, Li., Ni, Jianjiao., Yang, Xi., Tong, Tong., Wang, Jialei., ... & Zhu, Zhengfei. (2019). Radiographic Features of Metastatic Brain Tumors from ALK-rearranged Non-small Cell Lung Cancer: Implications for Optimal Treatment Modalities. JOURNAL OF CANCER, 10(26), 6660-6665.
MLA	Chu, Li,et al."Radiographic Features of Metastatic Brain Tumors from ALK-rearranged Non-small Cell Lung Cancer: Implications for Optimal Treatment Modalities".JOURNAL OF CANCER 10.26(2019):6660-6665.