Metabolic-associated fatty liver disease and major adverse cardiac events in patients with chronic coronary syndrome: a matched case-control study

doi:10.1007/s12072-021-10252-0

科研成果详情

题名	Metabolic-associated fatty liver disease and major adverse cardiac events in patients with chronic coronary syndrome: a matched case-control study
作者	Liu, Hui-Hui 1; Cao, Ye-Xuan 1; Jin, Jing-Lu 1; Guo, Yuan-Lin 1; Zhu, Cheng-Gang 1; Wu, Na-Qiong 1; Gao, Ying 1; Xu, Rui-Xia 1; Dong, Qian 1; Zheng, Ming-Hua2; Li, Jian-Jun 1
发表日期	2021-12
发表期刊	HEPATOLOGY INTERNATIONAL 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Fatty liver disease Metabolic-associated fatty liver disease Non-alcoholic fatty liver disease Chronic coronary syndrome Coronary artery disease Cardiovascular disease Secondary prevention Major adverse cardiac event Risk factor Outcome
摘要	Background and aims A consensus of experts suggests that nonalcoholic fatty liver disease (NAFLD) does not appropriately reflect current knowledge and metabolic-associated fatty liver disease (MAFLD) is supposed to be a more suitable overarching concept. However, the association of MAFLD with cardiovascular outcomes in patients with coronary artery disease has not been examined yet. Thus, this study aimed to assess the impact of MAFLD on major adverse cardiac events (MACEs) in patients with chronic coronary syndrome (CCS). Methods This study included 3306 patients with CCS who were diagnosed with MAFLD. Controls without MAFLD were matched (1:1) to cases by age and gender. All participants were followed up for the occurrence of MACEs. Finally, the association between MAFLD and the risk of MACEs was assessed. Results During an average of 55.09 +/- 19.92 months follow-up, 376 and 248 MACEs were observed in MAFLD and control groups, respectively. When compared with controls, Kaplan-Meier analysis showed that patients with MAFLD had significantly lower event-free survival rate and multivariate Cox regression analysis further revealed that MAFLD group had significantly increased MACEs risk (both p < 0.05). Stratification analysis suggested that patients with MAFLD overlapped with NAFLD or MAFLD-only had 1.33-fold and 2.32-fold higher risk of MACEs respectively compared with controls (both p < 0.05). Conclusion This study firstly showed that MAFLD was significantly associated with the risk of MACEs in patients with CCS. Moreover, this relationship remained unchanged irrespective of whether satisfying the NAFLD criteria, providing novel evidence for the good utility of MAFLD criteria in clinical practice.
资助项目	Capital Health Development Fund [201614035]; CAMS Major Collaborative Innovation Project [2016-I2M-1-011]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2019-XHQN09]; Youth Research Fund of Peking Union Medical College [2019-F11]
出版者	SPRINGER
出版地	NEW YORK
ISSN	1936-0533
EISSN	1936-0541
卷号	15 期号:6 页码:1337-1346
DOI	10.1007/s12072-021-10252-0
页数	10
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:000705801800001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	34626331
SCOPUSEID	2-s2.0-85116725291
通讯作者地址	[Li, Jian-Jun]State Key Laboratory of Cardiovascular Disease,FuWai Hospital,National Center for Cardiovascular Diseases,National Clinical Research Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,No. 167 BeiLiShi Road, XiCheng District,Beijing,100037,China
Scopus学科分类	Hepatology
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8059
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院
通讯作者	Li, Jian-Jun
作者单位	1.State Key Laboratory of Cardiovascular Disease,FuWai Hospital,National Center for Cardiovascular Diseases,National Clinical Research Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,No. 167 BeiLiShi Road, XiCheng District,Beijing,100037,China; 2.Department of Hepatology,MAFLD Research Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
推荐引用方式 GB/T 7714	Liu, Hui-Hui,Cao, Ye-Xuan,Jin, Jing-Lu,et al. Metabolic-associated fatty liver disease and major adverse cardiac events in patients with chronic coronary syndrome: a matched case-control study[J]. HEPATOLOGY INTERNATIONAL,2021,15(6):1337-1346.
APA	Liu, Hui-Hui., Cao, Ye-Xuan., Jin, Jing-Lu., Guo, Yuan-Lin., Zhu, Cheng-Gang., ... & Li, Jian-Jun. (2021). Metabolic-associated fatty liver disease and major adverse cardiac events in patients with chronic coronary syndrome: a matched case-control study. HEPATOLOGY INTERNATIONAL, 15(6), 1337-1346.
MLA	Liu, Hui-Hui,et al."Metabolic-associated fatty liver disease and major adverse cardiac events in patients with chronic coronary syndrome: a matched case-control study".HEPATOLOGY INTERNATIONAL 15.6(2021):1337-1346.