S1PR1 predicts patient survival and promotes chemotherapy drug resistance in gastric cancer cells through STAT3 constitutive activation

doi:10.1016/j.ebiom.2018.10.005

科研成果详情

题名	S1PR1 predicts patient survival and promotes chemotherapy drug resistance in gastric cancer cells through STAT3 constitutive activation
作者	Song, Shiyu 1; Min, Haiyan 1; Niu, Mengyuan 1; Wang, Lei 1; Wu, Yongzheng 1; Zhang, Bin 2; Chen, Xiufang3; Liang, Qiao 1; Wen, Yanting 1; Wang, Yong 1; Yi, Long 1; Wang, Hongwei 1; Gao, Qian 1
发表日期	2018-11
发表期刊	EBIOMEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	SPHINGOSINE 1-PHOSPHATE ; FTY720 ; SPHINGOSINE-1-PHOSPHATE ; INFLAMMATION ; EXPRESSION
摘要	Background: S1PR1-STAT3 inter-regulatory loop was initially suggested to be oncogenic in several cancer cells. However, the clinical relevance of this mechanism in tumor progression, disease prognosis and drug response was not established. Methods: The correlations between S1PR1 transcription, overall survival and chemotherapy response of GC patients were tested using a large clinical database. The relevance of S1PR1 expression and STAT3 activation in both tumor tissues and cancer cell lines was also tested. The effect of S1PR1 high expression achieved by persistent STAT3 activation on tumor cell drug resistance was investigated in vitro and in vivo. Findings: An enhanced S1PR1 expression was highly related with a reduced overall survival time and a worse response to chemotherapy drug and closer correlation to STAT3 in gastric cancer patients. The issue chip analysis showed that the expressions of S1PR1 and STAT3 activation were increased in higher graded gastric cancer (GC) tissues. Cellular studies supported the notion that the high S1PR1 expression was responsible for drug resistance in GC cells through a molecular pattern derived by constitutive activation of STAT3. The disruption of S1PR1 -STAT3 signaling significantly re-sensitized drug resistance in GC cells in vitro and in vivo. Interpretation: S1PR1-STAT3 signaling may participate drug resistance in GC, thus could serve as a drug target to increase the efficacy of GC treatment. (C) 2018 The Authors. Published by Elsevier B.V.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81570775, 81471095]; research projects in traditional Chinese medicine industry of China [201507004-2]
出版者	ELSEVIER SCIENCE BV
出版地	AMSTERDAM
ISSN	2352-3964
卷号	37 页码:168-176
DOI	10.1016/j.ebiom.2018.10.005
页数	9
WOS类目	Medicine, General & Internal ; Medicine, Research & Experimental
WOS研究方向	General & Internal Medicine ; Research & Experimental Medicine
WOS记录号	WOS:000451691900032
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	30316864
PMC记录号	PMC6284371
Scopus记录号	2-s2.0-85054456301
通讯作者地址	[Wang, Hongwei]Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine,Medical School of Nanjing University,Nanjing,210093,China
scopus学科分类	Biochemistry, Genetics and Molecular Biology (all)
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/7938
专题	检验医学院（生命科学学院、生物学实验教学中心）_生物化学与分子生物学系基础医学院（机能实验教学中心）
通讯作者	Wang, Hongwei
作者单位	1.Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine,Medical School of Nanjing University,Nanjing,210093,China; 2.Central Laboratory,Nanjing Chest Hospital,Medical School of Southeast University,Nanjing,210029,China; 3.Department of Biochemistry,School of Basic Medical Sciences,Wenzhou Medical University,Wenzhou,325035,China
推荐引用方式 GB/T 7714	Song, Shiyu,Min, Haiyan,Niu, Mengyuan,et al. S1PR1 predicts patient survival and promotes chemotherapy drug resistance in gastric cancer cells through STAT3 constitutive activation[J]. EBIOMEDICINE,2018,37:168-176.
APA	Song, Shiyu., Min, Haiyan., Niu, Mengyuan., Wang, Lei., Wu, Yongzheng., ... & Gao, Qian. (2018). S1PR1 predicts patient survival and promotes chemotherapy drug resistance in gastric cancer cells through STAT3 constitutive activation. EBIOMEDICINE, 37, 168-176.
MLA	Song, Shiyu,et al."S1PR1 predicts patient survival and promotes chemotherapy drug resistance in gastric cancer cells through STAT3 constitutive activation".EBIOMEDICINE 37(2018):168-176.