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TitleProteomic and Metabolomic Characterization of COVID-19 Patient Sera
Creator
Date Issued2020-07-09
Source PublicationCELL   Impact Factor & Quartile
language英语
Original Document TypeArticle
KeywordCOVID-19 metabolomics proteomics serum severity.
WOS KeywordACUTE RESPIRATORY SYNDROME ; EARLY-STAGE ; LUNG ; COMPLEMENT ; DISEASE ; SYSTEM ; LIPIDS
AbstractEarly detection and effective treatment of severe COVID-19 patients remain major challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID-19 and 53 control individuals. We then trained a machine learning model using proteomic and metabolomic measurements from a training cohort of 18 non-severe and 13 severe patients. The model was validated using 10 independent patients, 7 of which were correctly classified. Targeted proteomics and metabolomics assays were employed to further validate this molecular classifier in a second test cohort of 19 COVID-19 patients, leading to 16 correct assignments. We identified molecular changes in the sera of COVID-19 patients compared to other groups implicating dysregulation of macrophage, platelet degranulation, complement system pathways, and massive metabolic suppression. This study revealed characteristic protein and metabolite changes in the sera of severe COVID-19 patients, which might be used in selection of potential blood biomarkers for severity evaluation.
Funding ProjectTencent Foundation (2020); National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81972492, 21904107, 81672086]; Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars [LR19C050001]; Hangzhou Agriculture and Society Advancement Program [20190101A04]
PublisherCELL PRESS
Publication PlaceCAMBRIDGE
ISSN0092-8674
EISSN1097-4172
Volume182Issue:1Pages:59-+
DOI10.1016/j.cell.2020.05.032
Page Number29
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000549184500008
Indexed BySCIE ; PUBMED ; SCOPUS
URL查看原文
PubmedId32492406
PMCIDPMC7254001
scopusid2-s2.0-85085772268
ESI Hot Paper2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-03
ESI Hicited Paper2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05
CNS Important PaperCNS重要论文
User Journal ClassificationT1类
Corresponding author address[Zhu, Yi]Key Laboratory of Structural Biology of Zhejiang Province,School of Life Sciences,Westlake University,18 Shilongshan Road,Hangzhou,310024,China ; [Liu, Huafen]Calibra Lab at DIAN Diagnostics,329 Jinpeng Street,Hangzhou,310030,China ; [Chen, Haixiao]Taizhou Hospital,Wenzhou Medical University,150 Ximen Street,Linhai,317000,China ; [Guo, Tiannan]Key Laboratory of Structural Biology of Zhejiang Province,School of Life Sciences,Westlake University,18 Shilongshan Road,Hangzhou,310024,China
scopus subject classificationBiochemistry, Genetics and Molecular Biology (all)
Citation statistics
Cited Times:440[WOS]   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
Identifierhttps://kms.wmu.edu.cn/handle/3ETUA0LF/7926
Collection
Corresponding AuthorZhu, Yi; Liu, Huafen; Chen, Haixiao; Guo, Tiannan
Affiliation
1.Taizhou Hospital,Wenzhou Medical University,150 Ximen Street,Linhai,317000,China;
2.Key Laboratory of Structural Biology of Zhejiang Province,School of Life Sciences,Westlake University,18 Shilongshan Road,Hangzhou,310024,China;
3.Institute of Basic Medical Sciences,Westlake Institute for Advanced Study,18 Shilongshan Road,Hangzhou,310024,China;
4.Calibra Lab at DIAN Diagnostics,329 Jinpeng Street,Hangzhou,310030,China
First Author Affilication附属台州医院(浙江省台州医院);  附属台州医院
Corresponding Author Affilication附属台州医院(浙江省台州医院);  附属台州医院
First Signature Affilication附属台州医院(浙江省台州医院)
Recommended Citation
GB/T 7714
Shen, Bo,Yi, Xiao,Sun, Yaoting,et al. Proteomic and Metabolomic Characterization of COVID-19 Patient Sera[J]. CELL,2020,182(1):59-+.
APA Shen, Bo., Yi, Xiao., Sun, Yaoting., Bi, Xiaojie., Du, Juping., ... & Guo, Tiannan. (2020). Proteomic and Metabolomic Characterization of COVID-19 Patient Sera. CELL, 182(1), 59-+.
MLA Shen, Bo,et al."Proteomic and Metabolomic Characterization of COVID-19 Patient Sera".CELL 182.1(2020):59-+.

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