Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

doi:10.1016/j.cell.2020.05.032

科研成果详情

题名	Proteomic and Metabolomic Characterization of COVID-19 Patient Sera
作者	Shen, Bo1; Yi, Xiao 2,3; Sun, Yaoting 2,3; Bi, Xiaojie1; Du, Juping 1; Zhang, Chao 4; Quan, Sheng 4; Zhang, Fangfei 2,3; Sun, Rui 2,3; Qian, Liujia 2,3; Ge, Weigang 2,3; Liu, Wei 2,3; Liang, Shuang 2,3; Chen, Hao 2,3; Zhang, Ying 1; Li, Jun 1; Xu, Jiaqin 1; He, Zebao1; Chen, Baofu1; Wang, Jing 1; Yan, Haixi 1; Zheng, Yufen 1; Wang, Donglian 1; Zhu, Jiansheng1; Kong, Ziqing 4; Kang, Zhouyang 4; Liang, Xiao 2,3; Ding, Xuan 2,3; Ruan, Guan 2,3; Xiang, Nan 2,3; Cai, Xue 2,3; Gao, Huanhuan 2,3; Li, Lu 2,3; Li, Sainan 2,3; Xiao, Qi 2,3; Lu, Tian 2,3; Zhu, Yi 2,3; Liu, Huafen 4; Chen, Haixiao1; Guo, Tiannan 2,3
发表期刊	CELL 影响因子和分区
语种	英语
原始文献类型	Article
关键词	COVID-19 metabolomics proteomics serum severity.
其他关键词	ACUTE RESPIRATORY SYNDROME ; EARLY-STAGE ; LUNG ; COMPLEMENT ; DISEASE ; SYSTEM ; LIPIDS
摘要	Early detection and effective treatment of severe COVID-19 patients remain major challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID-19 and 53 control individuals. We then trained a machine learning model using proteomic and metabolomic measurements from a training cohort of 18 non-severe and 13 severe patients. The model was validated using 10 independent patients, 7 of which were correctly classified. Targeted proteomics and metabolomics assays were employed to further validate this molecular classifier in a second test cohort of 19 COVID-19 patients, leading to 16 correct assignments. We identified molecular changes in the sera of COVID-19 patients compared to other groups implicating dysregulation of macrophage, platelet degranulation, complement system pathways, and massive metabolic suppression. This study revealed characteristic protein and metabolite changes in the sera of severe COVID-19 patients, which might be used in selection of potential blood biomarkers for severity evaluation.
资助项目	Tencent Foundation (2020); National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81972492, 21904107, 81672086]; Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars [LR19C050001]; Hangzhou Agriculture and Society Advancement Program [20190101A04]
出版者	CELL PRESS
出版地	CAMBRIDGE
ISSN	0092-8674
EISSN	1097-4172
卷号	182 期号:1 页码:59-+
DOI	10.1016/j.cell.2020.05.032
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:000549184500008
收录类别	SCIE ; PUBMED ; SCOPUS
发表日期	2020-07-09
URL	查看原文
Pubmed记录号	32492406
PMC记录号	PMC7254001
Scopus记录号	2-s2.0-85085772268
ESI热点论文	2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-03
ESI高被引论文	2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03
CNS重要论文	CNS重要论文
自科自定义期刊分类	T1类
引用统计	被引频次：440[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/7926
专题	其他_附属台州医院（浙江省台州医院）
通讯作者	Zhu, Yi; Liu, Huafen; Chen, Haixiao; Guo, Tiannan
作者单位	1.Wenzhou Med Univ, Taizhou Hosp, 150 Ximen St, Linhai 317000, Zhejiang, Peoples R China; 2.Westlake Univ, Sch Life Sci, Key Lab Struct Biol Zhejiang Prov, 18 Shilongshan Rd, Hangzhou 310024, Zhejiang, Peoples R China; 3.Westlake Inst Adv Study, Inst Basic Med Sci, 18 Shilongshan Rd, Hangzhou 310030, Zhejiang, Peoples R China; 4.Calibra Lab DIAN Diagnost, 329 Jinpeng St, Hangzhou 310030, Zhejiang, Peoples R China
第一作者单位	附属台州医院（浙江省台州医院）; 附属台州医院
通讯作者单位	附属台州医院（浙江省台州医院）; 附属台州医院
第一作者的第一单位	附属台州医院（浙江省台州医院）
推荐引用方式 GB/T 7714	Shen, Bo,Yi, Xiao,Sun, Yaoting,et al. Proteomic and Metabolomic Characterization of COVID-19 Patient Sera[J]. CELL,2020,182(1):59-+.
APA	Shen, Bo., Yi, Xiao., Sun, Yaoting., Bi, Xiaojie., Du, Juping., ... & Guo, Tiannan. (2020). Proteomic and Metabolomic Characterization of COVID-19 Patient Sera. CELL, 182(1), 59-+.
MLA	Shen, Bo,et al."Proteomic and Metabolomic Characterization of COVID-19 Patient Sera".CELL 182.1(2020):59-+.