绝经后2型糖尿病患者骨质疏松相关因素分析

doi:10.3760/cma.j.issn.0254-9026.2009.03.011

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题名	绝经后2型糖尿病患者骨质疏松相关因素分析
其他题名	Analysis of related factors for osteoporosis in postmenopansal patients with type 2 diabetes mellitus
作者	叶成夫; 项旻; 杨士桂; 曾伟伟; 黄贤恩; 陈良苗
发表日期	2009-03-14
发表期刊	中华老年医学杂志影响因子和分区
语种	中文
原始文献类型	学术期刊
关键词	骨质疏松绝经后糖尿病 2型白细胞介素6
其他关键词	Osteoporosis ; postmenopansal ; Diabetes mellitus ; type 2 ; Interleukin-6
摘要	目的探讨绝经后2型糖尿病(T2DM)患者骨质疏松的相关因素。方法采用双能X线骨密度仪测定79例绝经后T2DM患者的正位腰椎(L1-4)、左股骨颈与左股骨粗隆及左全髋骨密度,根据骨密度值分为骨质疏松组与非骨质疏松组,并对测定的相关化验指标、年龄、病程、绝经年龄、绝经年限及体质指数(BMI)等进行对比分析。结果两组年龄、BMI、白细胞介素6(IL-6)、骨钙素、绝经年限差异均有统计学意义,直线相关分析显示IL-6与骨质疏松(r=0.260,P=0.020)及糖化血红蛋白(GHbA1c)(r=0.259,P=0.023)相关;Loglstic多因素回归分析显示,绝经后T2DM患者骨质疏松的发生与年龄独立相关,与BMI独立负相关。结论年龄与低BMI可能是绝经后T2DM患者骨质疏松发生的独立危险因素。
其他摘要	Objective To investigate the morbidity and related factors for osteoporosis in postmenopausal patients with type 2 diabetes mellitus (T2DM).Methods The bone mineral density (BMD) at lumbar vertebrae(L_(1-4)), left femoral neck, femoral trochanter and total hip were measured by dual energy X-ray absorptiometry (DEXA) in 79 postmenopansal patients with T2DM.The patients were divided into two groups: osteoporosis group and non-osteoporosis group.The correlations between BMD and age, course of disease, menopausal age, menopausal duration and body mass index (BMI) were analyzed by multivariate regression analysis.Results There were significantly statistical differences in age, BMI, interleukin 6 (IL-6), osteocalcin and menopause duration between two groups.Linear correlation analysis showed IL-6 was positively correlated with osteoporosis (r=0.260, P=0.020) and glycosylated hemoglobin (GHbAlc) (r=0.259, P=0.023) Logistic regression analysis showed that the morbidity of osteoporosis had an independent positive correlation with age, but an independent negative correlation with BMI.Conclusions In postmenopausal patients with T2DM, age and low BMI are independent risk factors for osteoporosis.
ISSN	0254-9026
卷号	28 期号:03 页码:210-212
DOI	10.3760/cma.j.issn.0254-9026.2009.03.011
页数	0
收录类别	CNKI ; 万方 ; 北大核心 ; PKU ; CSCD ; ISTIC
学科领域	医药、卫生 ; 内科学
URL	查看原文
CSCD记录号	CSCD:3648310
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/77282
专题	第二临床医学院、附属第二医院、育英儿童医院_内科学_内分泌
作者单位	温州医学院附属三院内分泌科
第一作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	叶成夫,项旻,杨士桂,等. 绝经后2型糖尿病患者骨质疏松相关因素分析[J]. 中华老年医学杂志,2009,28(03):210-212.
APA	叶成夫, 项旻, 杨士桂, 曾伟伟, 黄贤恩, & 陈良苗. (2009). 绝经后2型糖尿病患者骨质疏松相关因素分析. 中华老年医学杂志, 28(03), 210-212.
MLA	叶成夫,et al."绝经后2型糖尿病患者骨质疏松相关因素分析".中华老年医学杂志 28.03(2009):210-212.