Cardamonin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and migration by downregulating p38 MAPK, Akt, and ERK phosphorylation

doi:10.1007/s11418-014-0825-0

科研成果详情

题名	Cardamonin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and migration by downregulating p38 MAPK, Akt, and ERK phosphorylation
作者	Shen, Yan-Jing 1; Zhu, Xue-Xin 1; Yang, Xian 1; Jin, Bo 1; Lu, Jin-Jian 2; Ding, Bin 1; Ding, Zhi-Shan 1; Chen, Su-Hong3
发表日期	2014-07
发表期刊	JOURNAL OF NATURAL MEDICINES 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Cardamonin Angiotensin II Vascular smooth muscle cell MAPK Akt
其他关键词	PATHWAY ; ACTIVATION ; FLAVONOIDS ; RECEPTOR
摘要	Cardamonin is a chalconoid isolated from various herbs, such as Alpinia katsumadai and Carya cathayensis Sarg. This study examined the effect of cardamonin on angiotensin II (Ang II)-induced proliferation and migration in rat vascular smooth muscle cells (VSMCs) as well as its underlying mechanisms. The results showed that cardamonin significantly inhibited Ang II-induced proliferation and migration in rat VSMCs in a concentration-dependent manner. Moreover, cardamonin suppressed Ang II-induced phosphorylation of p38 MAPK, Akt, and extracellular regulated protein kinase (ERK). These findings indicate that the downregulation of p38 MAPK, Akt, and ERK phosphorylation might be, at least in part, involved in cardamonin-suppressed proliferation and migration induced by Ang II in rat VSMCs. As proliferation and migration of VSMCs play critical roles in the pathogenesis of atherosclerosis, cardamonin might be a potential candidate for atherosclerosis treatment.
资助项目	National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81303258]; Medical Scientific Research of Zhejiang Province [2012KYB136]
出版者	SPRINGER JAPAN KK
出版地	TOKYO
ISSN	1340-3443
EISSN	1861-0293
卷号	68 期号:3 页码:623-629
DOI	10.1007/s11418-014-0825-0
页数	7
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000337168300019
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	24595849
SCOPUSEID	2-s2.0-84904661299
通讯作者地址	[Chen, Su-Hong]Institute of Chinese Medicine, Wenzhou Medical University,Ouhai District,China
Scopus学科分类	Molecular Medicine
引用统计	被引频次：39[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/7636
专题	第一临床医学院（信息与工程学院）、附属第一医院_中医学
通讯作者	Chen, Su-Hong
作者单位	1.College of Life Sciences, Zhejiang Chinese Medical University,China; 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau,Macao; 3.Institute of Chinese Medicine, Wenzhou Medical University,Ouhai District,China
通讯作者单位	温州医科大学
推荐引用方式 GB/T 7714	Shen, Yan-Jing,Zhu, Xue-Xin,Yang, Xian,et al. Cardamonin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and migration by downregulating p38 MAPK, Akt, and ERK phosphorylation[J]. JOURNAL OF NATURAL MEDICINES,2014,68(3):623-629.
APA	Shen, Yan-Jing., Zhu, Xue-Xin., Yang, Xian., Jin, Bo., Lu, Jin-Jian., ... & Chen, Su-Hong. (2014). Cardamonin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and migration by downregulating p38 MAPK, Akt, and ERK phosphorylation. JOURNAL OF NATURAL MEDICINES, 68(3), 623-629.
MLA	Shen, Yan-Jing,et al."Cardamonin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and migration by downregulating p38 MAPK, Akt, and ERK phosphorylation".JOURNAL OF NATURAL MEDICINES 68.3(2014):623-629.