Association between PLA2G12A polymorphism and patients with schizophrenia in a southern Chinese Han population

doi:10.1002/hup.2654

科研成果详情

题名	Association between PLA2G12A polymorphism and patients with schizophrenia in a southern Chinese Han population
作者	Hui, Li 1; Yin, Xiao Li 2; Chen, Jie 1; Zhu, Hong Liang 1; Zhang, Guang Ya 1; Wang, Xiao Qiong 2; Liu, Jia Hong 2; Zhu, Cheng 2; Xu, Dong Wu 3; Yu, Xin3,4; Yin, Guang Zhong 1
发表日期	2018-03
发表期刊	HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL 影响因子和分区
语种	英语
原始文献类型	Article
关键词	association PLA2G12A polymorphism schizophrenia
其他关键词	CYTOSOLIC PHOSPHOLIPASE-A2 GENE ; A(2) ACTIVITY ; CPLA2 ; LOCI
摘要	BackgroundElevated phospholipase A2 (PLA2) activity is reported to be involved in the development of schizophrenia. Further study revealed an association between PLA2 groups XIIA (PLA2G12A) polymorphism and patients with schizophrenia in a northeast Chinese Han population. ObjectiveThis study will further examine whether PLA2G12A rs3087494 polymorphism is associated with patients with schizophrenia in a southern Chinese Han population. MethodsThis polymorphism was genotyped in 438 patients with schizophrenia (diagnosed according to Diagnostic and Statistical Manual of Mental Disorders-IV) and 876 healthy controls using a case-control design. Demographic and clinical data were collected in all subjects. ResultsThe allele and genotype frequencies of PLA2G12A rs3087494 polymorphism significantly differed between groups (both, p<.001). These differences still were significant by adjusting for sex and age. However, there was no difference in age at onset among 3 genotype groups in patients with schizophrenia by adjusting for the variables (F=0.22, p=.80). Stepwise multivariate regression analysis showed that this polymorphism was not associated with age at onset in patients with schizophrenia (=.008, t=.07, p=.94). ConclusionsOur results indicated that even though PLA2G12A rs3087494 polymorphism did not influence age at onset in patients with schizophrenia, it may play an important role in the susceptibility to schizophrenia in a southern Chinese Han population.
资助项目	Young Medical Talent of Jiangsu Province [QNRC2016228]; Zhejiang Province Rising Star in Medicine; Wenzhou Municipal Sci-Tech Bureau Program [Y20170077]; Suzhou Municipal Sci-Tech Bureau Program [SYSD2015136]; Suzhou Key Laboratory for Biological Psychiatry [SZS201722]; Suzhou Key Medical Center for Psychiatric Diseases [Szzx201509]; Jiangsu Preventive Medicine Association Program [Y2015027]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81501160, 81771439]
出版者	WILEY
出版地	HOBOKEN
ISSN	0885-6222
EISSN	1099-1077
卷号	33 期号:2 页码:e2654.
DOI	10.1002/hup.2654
页数	5
WOS类目	Clinical Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS记录号	WOS:000428326500006
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29527719
SCOPUSEID	2-s2.0-85044419621
通讯作者地址	[Hui, Li]Institute of Mental Health,Suzhou Psychiatric Hospital,The Affiliated Guangji Hospital of Soochow University,Suzhou,China
Scopus学科分类	Neurology;Neurology (clinical);Psychiatry and Mental Health;Pharmacology (medical)
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/7541
专题	温州医科大学精神医学学院
通讯作者	Hui, Li
作者单位	1.Institute of Mental Health,Suzhou Psychiatric Hospital,The Affiliated Guangji Hospital of Soochow University,Suzhou,China; 2.Kangning Hospital attached to Wenzhou Medical University,Wenzhou,China; 3.School of Mental Health,Wenzhou Medical University,Wenzhou,China; 4.Institute of Mental Health,Peking University,Beijing,China
推荐引用方式 GB/T 7714	Hui, Li,Yin, Xiao Li,Chen, Jie,et al. Association between PLA2G12A polymorphism and patients with schizophrenia in a southern Chinese Han population[J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,2018,33(2):e2654..
APA	Hui, Li., Yin, Xiao Li., Chen, Jie., Zhu, Hong Liang., Zhang, Guang Ya., ... & Yin, Guang Zhong. (2018). Association between PLA2G12A polymorphism and patients with schizophrenia in a southern Chinese Han population. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 33(2), e2654..
MLA	Hui, Li,et al."Association between PLA2G12A polymorphism and patients with schizophrenia in a southern Chinese Han population".HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL 33.2(2018):e2654..