Effective treatment of esophageal carcinomas using intensity-modulated radiotherapy in combination with nedaplatin and docetaxel

doi:10.3892/ol.2012.735

科研成果详情

题名	Effective treatment of esophageal carcinomas using intensity-modulated radiotherapy in combination with nedaplatin and docetaxel
作者	Chen, Wenjun 1; Wang, Jianhua1; Zhao, Kuaile 2; Yuan, Shaofei 1; Wang, Yubin 1; Lin, Yucheng 1; Shi, Xuehui 2; Xiong, Jiangping 3
发表日期	2012-08
发表期刊	ONCOLOGY LETTERS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	esophageal carcinoma intensity-modulated radiotherapy weekly dose of chemotherapy nedaplatin docetaxel
其他关键词	SQUAMOUS-CELL CARCINOMA ; DOSE RADIATION ; CANCER ; CHEMOTHERAPY ; TRIAL ; CISPLATIN ; CHEMORADIOTHERAPY ; 5-FLUOROURACIL ; INTERGROUP
摘要	Esophageal carcinoma is one of the most common types of cancer. Traditional surgery or radiotherapy alone is not sufficiently effective and the median survival period is nine months. The results of previous studies indicate that the efficacy of the treatment cannot be improved by increasing the doses of radiotherapy and cisplatin with 5-fluorouracil. In this study, we performed radiotherapy in combination with weekly nedaplatin plus docetaxel chemotherapy to determine the curative and toxicity effects of these treatments. The mean survival period of patients with pathological complete remission (pCR) was 47.8 months (range, 35.3-60.6), which was longer than that of the partial pathological remission (pPR) patients (mean, 17.8 months; range, 8.7-53.3). Furthermore, the relative risk of pCR mortality was lower compared with that of the non-pathological complete remission (no-pCR) patients, which were 0.088 [95% confidence interval (CI), 0.029-0.265] and 0.08 (95% CI, 0.028-0.225), respectively. These results suggest that the pCR patients, compared with the pPR patients (or no-pCR patients), had a significant survival advantage. The findings have shown that the chemotherapy regimen used in this study is able to significantly increase the effect of radiotherapy and reduce the toxicity effects of chemotherapy. Dose intensity-modulated radiotherapy (IMRT) reduces the irradiation volume, thus the target area is smaller than in the conventional methods.
出版者	SPANDIDOS PUBL LTD
出版地	ATHENS
ISSN	1792-1074
EISSN	1792-1074
卷号	4 期号:2 页码:346-350
DOI	10.3892/ol.2012.735
页数	5
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000305927900032
收录类别	SCIE ; SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-84861981178
通讯作者地址	[Chen, Wenjun]Cancer Center,The Third Hospital of Wenzhou Medical College,China
Scopus学科分类	Oncology;Cancer Research
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/7416
专题	其他_浙江省肿瘤医院（浙江省癌症中心）
通讯作者	Chen, Wenjun
作者单位	1.Cancer Center,The Third Hospital of Wenzhou Medical College,China; 2.Department of Radiotherapy,Cancer Hospital of Fudan University,China; 3.Department of Oncology,The First Affiliated Hospital of Nanchang University,Yongwaizheng Road 17,China
第一作者单位	其他_浙江省肿瘤医院（浙江省癌症中心）
通讯作者单位	其他_浙江省肿瘤医院（浙江省癌症中心）
第一作者的第一单位	其他_浙江省肿瘤医院（浙江省癌症中心）
推荐引用方式 GB/T 7714	Chen, Wenjun,Wang, Jianhua,Zhao, Kuaile,et al. Effective treatment of esophageal carcinomas using intensity-modulated radiotherapy in combination with nedaplatin and docetaxel[J]. ONCOLOGY LETTERS,2012,4(2):346-350.
APA	Chen, Wenjun., Wang, Jianhua., Zhao, Kuaile., Yuan, Shaofei., Wang, Yubin., ... & Xiong, Jiangping. (2012). Effective treatment of esophageal carcinomas using intensity-modulated radiotherapy in combination with nedaplatin and docetaxel. ONCOLOGY LETTERS, 4(2), 346-350.
MLA	Chen, Wenjun,et al."Effective treatment of esophageal carcinomas using intensity-modulated radiotherapy in combination with nedaplatin and docetaxel".ONCOLOGY LETTERS 4.2(2012):346-350.