胃癌术后同步放化疗64例临床分析

doi:10.3760/cma.j.issn.1008-6706.2010.09.023

科研成果详情

题名	胃癌术后同步放化疗64例临床分析
其他题名	Postoperative radiotherapy concurrent with paclitaxel and cisplatin in the adjuvant treatment of gastric cancer:An analysis of 64 cases
作者	张薛榜; 李刚; 邓霞; 邹长林; 谢聪颖; 景钊; 吴式琇
发表日期	2010-05-01
发表期刊	中国基层医药影响因子和分区
语种	中文
原始文献类型	学术期刊
关键词	胃肿瘤化学疗法辅助放射疗法适形
其他关键词	Stomach neoplasms ; Chemotherapy ; adjuvant ; Radiotherapy ; conformal
摘要	目的评价胃癌术后放疗同步紫杉醇顺铂方案治疗的临床疗效和毒性反应,比较适形放疗与常规放疗在放疗毒性反应方面的差异。方法采用常规4野或三维适形放疗技术DT 60 Gy和紫杉醇135 mg/m~2第1天,顺铂20 mg/m~2第1～3天同步化疗,4周1次共2周期。结果 3年总生存率、3年无复发生存期分别为78.2%、70.9%,28.1%患者出现治疗失败。3级及以上毒性反应发生率为70.3%,主要毒性反应为消化道(28.1%)、血液学毒性(21.8%)和脱发(18.7%),l例患者发生治疗相关死亡。结论胃癌术后的同步化疗方案效果较好,安全可行;适形放疗技术可以进一步减轻放疗相关毒性反应尤其是胃肠道反应。
其他摘要	Objective To evaluate the efficacy and toxicity of postoperative chemoradiation for D2 dissection gastric cancer,and to compare the difference of toxicity between confromal and traditional radiotherapy.Methods Sixty four patients with T3-4,N + or R1 were enrolled.Radioation was given to a total dose of 46Gy delivered in 23fractions by use of 3D-CRT or 4 fields traditional radiotherapy.Chemothrepy was administered with paclitaxel 135 mg/m2 day 1 and 29,cisplantin 20 mg/m2 day 1 ～3 and day 29 ～31 during radiotherapy.Results The median follow-up time was 40 months.The 3-year overall and relapse-free survival rates were 78.2% and 70.9%,respectively.Eighteen patients had tumor relapse.Fifty-three patients completed chemoradiotheray.Toxicities on grade 3 or above included gastrointestinal toxicity (28.1% ),eutropenia (21.8 % ) and alopecia ( 18.7% ).One patient died of hemorrhage of upper digestion tract.Conclusion Adjuvant radiotherapy with paclitaxol and cisplatin yielded satisfactory overall survival and disease-free survival in gastric cancer patients.The toxicity was manageable.Conformal radiotherapy seems to decrease the gastrointestinal toxicities compared to that occurred in the traditional radiotherapy.
资助项目	浙江省教育厅科研基金资助项目（20051171）;温州市科技计划项目（Y2006A031）
ISSN	1008-6706
卷号	17 期号:09 页码:1196-1198
DOI	10.3760/cma.j.issn.1008-6706.2010.09.023
页数	0
收录类别	CNKI ; 万方 ; ISTIC
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/71682
专题	附属第一医院_放化疗科
作者单位	温州医学院第一附属医院放化疗科
第一作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	张薛榜,李刚,邓霞,等. 胃癌术后同步放化疗64例临床分析[J]. 中国基层医药,2010,17(09):1196-1198.
APA	张薛榜., 李刚., 邓霞., 邹长林., 谢聪颖., ... & 吴式琇. (2010). 胃癌术后同步放化疗64例临床分析. 中国基层医药, 17(09), 1196-1198.
MLA	张薛榜,et al."胃癌术后同步放化疗64例临床分析".中国基层医药 17.09(2010):1196-1198.