原花青素对慢性应激大鼠抑郁样行为和肾上腺结构的影响

doi:10.3760/cma.j.issn.1674-6554.2010.07.012

科研成果详情

题名	原花青素对慢性应激大鼠抑郁样行为和肾上腺结构的影响
其他题名	The effects of proanthocyanidins on antidepressant-like behaviors and the adrenal gland in chronic stress rats
作者	陈桂香; 于捷; 张璐; 王璐静; 曹慧英; 严伊佳; 邵红波; 潘建春
发表日期	2010-07-20
发表期刊	中华行为医学与脑科学杂志影响因子和分区
语种	中文
原始文献类型	学术期刊
关键词	原花青素慢性应激开野实验肾上腺
其他关键词	Proanthocyanidins ; Chronic unpredictable mild stress ; Open-field test ; Adrenal gland
摘要	目的研究原花青素对慢性应激抑郁模型大鼠行为活动和肾上腺结构的影响。方法采用慢性不可预见性温和应激模型,连续造模给药21d后,测定大鼠开野活动,强迫游泳不动时间和糖水消耗量;测定应激大鼠肾上腺体质量比率和皮质厚度,HE染色观察应激大鼠肾上腺结构的改变。结果原花青素(25,50,100 mg·kg~(-1))组[(49±4.5)次,(52.6±3.7)次,(54.1±1.8)次]的开野活动相比慢性应激模型组[(39.6±3.4)次]显著增加(均P<0.001);原花青素(25,50,100 mg·kg~(-1))[(83.7±8.8)s,(75.8±5.9)s,(67.2±6.5)s]相比慢性应激组[(103.5±10.2)s]明显缩短大鼠的不动时间(均P<0.01);原花青素(25,50,100 mg·kg~(-1))[(8.1±3.3)ml,(8.5±4.1)ml,(9.2±2.6)m1]相比慢性应激模型组[(5.8±2.5)ml]明显增加大鼠糖水摄入量(P<0.05);原花青素(25,50,100 mg·kg~(-1))相比慢性应激模型能明显减小肾上腺体质量比率(P<0.05),减轻应激大鼠的肾上腺皮质厚度,差异有显著性(P<0.05,P<0.01)。结论原花青素能明显改善慢性不可预见性应激模型大鼠的抑郁样行为活动,对应激所致肾上腺的结构改变也有保护作用。
其他摘要	Objective To investigate the effects of proanthocyanidins on depressant-like behaviors and the structure of adrenal gland in chronic unpredictable mild stress (CUMS)rats. Methods Rats were randomly divided into 6 groups:control group, stressed group(CUMS+vehicle), three treatment groups(CUMS+proanthocyanidins 25,50,100 mg·kg~(-1), respectively), and imipramine group(CUMS+imipramine 10 mg·kg~(-1)). Used the CUMS model in rats to investigate the effects of chronic oral administration (21 days)of proanthocyanidins and imipramine(ip)on the open-field;and forced swimming and sucrose consumption tests and the ratio of adrenal gland/body weight, and its thickness were examined by HE stain. Results Compared with control group, rats subjected to CUMS exhibited increased ratio of adrenal gland/body weight(P<0.01), less sucrose consumption(P<0.01)and inhibited in the open-field test(P<0.01)as well as more despair time in the forced swimming test(P<0.01). While compared with stressed group, treatments with proan thocyanidins(25,50,100 mg ·kg~(-1),po,21 days)could significantly improve the activities in open-field test((39.6±3.4)vs (49±4.5), (52.6±3.7),(54.1±1.8);all. P<0.01)and sucrose consumption((5.8±2.5)ml vs (8.1±3.3)ml,(8.5± 4.1)ml,(9.2±2.6)ml;P<0.05,P<0.05,P<0.01 respectively);Meanwhile,it could reduce the duration time in forced swimming test significantly((103.5±10.2)s vs(83.7±8.8)s,(75.8±5.9)s,(67.2±6.5)s; all P<0.01)as well as thickness of the adrenal gland(P<0.05,P<0.01). Conclusions This study suggests that the proanthocyanidins (25,50,100 mg·kg~(-1))has an antidepressant-like effects in CUMS rats. The antidepressant actions of proanthocyanidins,in some degrees, may be related with the regulation of the adrenal gland's structure
资助项目	浙江省大学生科技创新“新苗计划”课题资助（2008R40G2090056）
ISSN	1674-6554
卷号	19 期号:07 页码:611-613
DOI	10.3760/cma.j.issn.1674-6554.2010.07.012
页数	0
收录类别	CNKI ; 万方 ; 北大核心 ; PKU ; CSCD ; ISTIC
学科领域	医药、卫生 ; 外科学
URL	查看原文
CSCD记录号	CSCD:3971976
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/70983
专题	药学院（分析测试中心）_实验神经生物研究所
作者单位	温州医学院实验神经生物学研究所
第一作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	陈桂香,于捷,张璐,等. 原花青素对慢性应激大鼠抑郁样行为和肾上腺结构的影响[J]. 中华行为医学与脑科学杂志,2010,19(07):611-613.
APA	陈桂香., 于捷., 张璐., 王璐静., 曹慧英., ... & 潘建春. (2010). 原花青素对慢性应激大鼠抑郁样行为和肾上腺结构的影响. 中华行为医学与脑科学杂志, 19(07), 611-613.
MLA	陈桂香,et al."原花青素对慢性应激大鼠抑郁样行为和肾上腺结构的影响".中华行为医学与脑科学杂志 19.07(2010):611-613.