Lotus leaf inspired antiadhesive and antibacterial gauze for enhanced infected dermal wound regeneration

doi:10.1016/j.cej.2020.126202

科研成果详情

题名	Lotus leaf inspired antiadhesive and antibacterial gauze for enhanced infected dermal wound regeneration
作者	Li, Shengyu 1,2,3; Chen, Anqi 2; Chen, Yanxin 1; Yang, Yao 1; Zhang, Qianwen4; Luo, Sha 1; Ye, Mengqi 1; Zhou, Yajiao 2; An, Ying 2; Huang, Wen 2; Xuan, Tengxiao 2; Pan, Yuexiao 1; Xuan, Xuan4; He, Huacheng 1; Wu, Jiang2
发表日期	2020-12-15
发表期刊	CHEMICAL ENGINEERING JOURNAL 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Gauze Wound healing Dopamine Antibacterial Antiadhesive
其他关键词	CORE-SHELL NANOPARTICLE ; SILVER NANOPARTICLES ; SURFACE ; DRESSINGS ; HYDROGELS ; PETAL
摘要	Gauze is the leading dressing for wound management. However, infection and tissue adhesion pose serious challenges to the application of gauzes. Herein, inspired by the self-cleaning property of lotus leaf, we develop a novel antiadhesive and antibacterial gauze. The gauze, named Lotus@Gauze, is fabricated by decorating an ordinary medical gauze sequentially with polydopamine, perfluorocarbon and silver nanoparticle to obtain a lotus leaf-mimic surface structure. Lotus@Gauze exhibits excellent antiadhesive and antibacterial effects, and its antibacterial ability is enhanced under NIR irradiation due to the photothermal effect of polydopamine. Furthermore, in vivo results reveal that, in comparison with clinically available antiadhesive or antibacterial gauzes, Lotus@Gauze shows better efficacy in promoting infectious wound regeneration due to its low tissue adhesion and effective bactericidal activity. Overall, this study explores a new attempt to overcome the challenge of tissue adhesion and infection by integrating antiadhesive and antibacterial properties into one piece of simple gauze.
资助项目	Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LGF19H180008]; Zhejiang Qianjiang Talent project [QJD1803015]; Wenzhou Municipal Science & Technology Bureau of China [Y20190178]
出版者	ELSEVIER SCIENCE SA
出版地	LAUSANNE
ISSN	1385-8947
EISSN	1873-3212
卷号	402
DOI	10.1016/j.cej.2020.126202
页数	49
WOS类目	Engineering, Environmental ; Engineering, Chemical
WOS研究方向	Engineering
WOS记录号	WOS:000573514000007
收录类别	SCIE ; EI ; SCOPUS
EI入藏号	20202908952908
EI主题词	Adhesion
URL	查看原文
Scopus记录号	2-s2.0-85087934923
通讯作者地址	[He, Huacheng]College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou,325035,China
scopus学科分类	Chemistry (all);Environmental Chemistry;Chemical Engineering (all);Industrial and Manufacturing Engineering
引用统计	被引频次：41[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/6645
专题	药学院（分析测试中心）_生物制药系_生物制药工程附属第一医院
通讯作者	He, Huacheng
作者单位	1.College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou,325035,China; 2.School of Pharmaceutical Sciences,Key Laboratory of Biotechnology and Pharmaceutical Engineering,Wenzhou Medical University,Wenzhou,325035,China; 3.Second Clinical Medical College,Affiliated Secondary Hospital,Zhejiang Chinese Medical University,Hangzhou,310011,China; 4.Department of Dermatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China
第一作者单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Li, Shengyu,Chen, Anqi,Chen, Yanxin,et al. Lotus leaf inspired antiadhesive and antibacterial gauze for enhanced infected dermal wound regeneration[J]. CHEMICAL ENGINEERING JOURNAL,2020,402.
APA	Li, Shengyu., Chen, Anqi., Chen, Yanxin., Yang, Yao., Zhang, Qianwen., ... & Wu, Jiang. (2020). Lotus leaf inspired antiadhesive and antibacterial gauze for enhanced infected dermal wound regeneration. CHEMICAL ENGINEERING JOURNAL, 402.
MLA	Li, Shengyu,et al."Lotus leaf inspired antiadhesive and antibacterial gauze for enhanced infected dermal wound regeneration".CHEMICAL ENGINEERING JOURNAL 402(2020).