Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model

doi:10.1152/ajpendo.00026.2015

科研成果详情

题名	Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model
作者	Shao, Minglong1,2; Yu, Lechu2; Zhang, Fangfang 1,2; Lu, Xuemian1,2; Li, Xiaokun1; Cheng, Peng 1,2; Lin, Xiufei 1,2; He, Luqing 1,2; Jin, Shunzi 3; Tan, Yi1,2,4; Yang, Hong2; Zhang, Chi 1,2; Cai, Lu1,2,4
发表日期	2015-07-01
发表期刊	AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 影响因子和分区
语种	英语
原始文献类型	Article
关键词	low-dose radiation fibroblast growth factor-21 insulin resistance inflammation oxidative stress
其他关键词	LOW-DOSE-RADIATION ; ATOMIC-BOMB SURVIVORS ; GROWTH-FACTOR 21 ; MALE GERM-CELLS ; GAMMA-IRRADIATION ; INSULIN-RESISTANCE ; ADAPTIVE RESPONSE ; RENAL INJURY ; MICE ; HORMESIS
摘要	The onset of diabetic nephropathy (DN) is associated with both systemic and renal changes. Fibroblast growth factor (FGF)-21 prevents diabetic complications mainly by improving systemic metabolism. In addition, low-dose radiation (LDR) protects mice from DN directly by preventing renal oxidative stress and inflammation. In the present study, we tried to define whether the combination of FGF21 and LDR could further prevent DN by blocking its systemic and renal pathogeneses. To this end, type 2 diabetes was induced by feeding a high-fat diet for 12 wk followed by a single dose injection of streptozotocin. Diabetic mice were exposed to 50 mGy LDR every other day for 4 wk with and without 1.5 mg/kg FGF21 daily for 8 wk. The changes in systemic parameters, including blood glucose levels, lipid profiles, and insulin resistance, as well as renal pathology, were examined. Diabetic mice exhibited renal dysfunction and pathological abnormalities, all of which were prevented significantly by LDR and/or FGF21; the best effects were observed in the group that received the combination treatment. Our studies revealed that the additive renal protection conferred by the combined treatment against diabetes-induced renal fibrosis, inflammation, and oxidative damage was associated with the systemic improvement of hyperglycemia, hyperlipidemia, and insulin resistance. These results suggest that the combination treatment with LDR and FGF21 prevented DN more efficiently than did either treatment alone. The mechanism behind these protective effects could be attributed to the suppression of both systemic and renal pathways.
资助项目	National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81000294, 81370917, 81471045]; Research Development Fund of Wenzhou Medical University [QTJ13005]; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [1R01 DK091338-01A1]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [Y14H070033]; NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [R01DK091338] Funding Source: NIH RePORTER
出版者	AMER PHYSIOLOGICAL SOC
出版地	BETHESDA
ISSN	0193-1849
EISSN	1522-1555
卷号	309 期号:1 页码:E45-E54
DOI	10.1152/ajpendo.00026.2015
页数	10
WOS类目	Endocrinology & Metabolism ; Physiology
WOS研究方向	Endocrinology & Metabolism ; Physiology
WOS记录号	WOS:000357514300005
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	25968574
PMC记录号	PMC4490332
SCOPUSEID	2-s2.0-84935507294
通讯作者地址	[Zhang, Chi]Chinese-American Research Institute for Diabetic Complications,Wenzhou Medical University,Chashan Univ. Town,Wenzhou,325035,China
Scopus学科分类	Medicine (all)
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/6609
专题	温州医科大学
通讯作者	Zhang, Chi
作者单位	1.Chinese-American Research Institute for Diabetic Complications,Wenzhou Medical University,Wenzhou,China; 2.Ruian Center of Chinese-American Research Institute for Diabetic Complications,Wenzhou Medical University,Wenzhou,China; 3.Key Laboratory of Radiobiology (Ministry of Health),School of Public Health of Jilin University,Changchun,China; 4.Kosair Children’s Hospital Research Institute,Department of Pediatrics,University of Louisville School of Medicine,Louisville,United States
第一作者单位	温州医科大学;
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Shao, Minglong,Yu, Lechu,Zhang, Fangfang,et al. Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,2015,309(1):E45-E54.
APA	Shao, Minglong., Yu, Lechu., Zhang, Fangfang., Lu, Xuemian., Li, Xiaokun., ... & Cai, Lu. (2015). Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 309(1), E45-E54.
MLA	Shao, Minglong,et al."Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model".AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 309.1(2015):E45-E54.