SLC7A11/xCT in cancer: biological functions and therapeutic implications

科研成果详情

题名	SLC7A11/xCT in cancer: biological functions and therapeutic implications
作者	Lin, Wenyu 1; Wang, Chaoqun2; Liu, Guangping 3; Bi, Chao 4; Wang, Xian 5; Zhou, Qiyin 5; Jin, Hongchuan 1
发表日期	2020
发表期刊	AMERICAN JOURNAL OF CANCER RESEARCH 影响因子和分区
语种	英语
原始文献类型	Review
关键词	SLC7A11 cellular metabolism redox homeostasis ferroptosis drug resistance cancer redox homeostasis.
其他关键词	HUMAN BREAST-CANCER ; X(C)(-) CYSTINE/GLUTAMATE ANTIPORTER ; GLUTAMATE TRANSPORTER SLC7A11 ; AMINO-ACID TRANSPORTERS ; REGULATES REDOX STATUS ; MEDIATED RNA DECAY ; SYSTEM X(C)(-) ; CELL-DEATH ; CISPLATIN RESISTANCE ; MEMBRANE TOPOLOGY
摘要	Amino acid transporters mediate substrates across cellular membranes and their fine-tuned regulations are critical to cellular metabolism, growth, and death. As the functional component of system Xc-, which imports extracellular cystine with intracellular glutamate release at a ratio of 1:1, SLC7A11 has diverse functional roles in regulating many pathophysiological processes such as cellular redox homeostasis, ferroptosis, and drug resistance in cancer. Notably, accumulated evidence demonstrated that SLC7A11 is overexpressed in many types of cancers and is associated with patients' poor prognosis. As a result, SLC7A11 becomes a new potential target for cancer therapy. In this review, we first briefly introduce the structure and function of SLC7A11, then discuss its pathological role in cancer. We next summarize current available data of how SLC7A11 is subjected to fine regulations at multiple levels. We further describe the potential inhibitors of the SLC7A11 and their roles in human cancer cells. Finally, we propose novel insights for future perspectives on the modulation of SLC7A11, as well as possible targeted strategies for SLC7A11-based anti-cancer therapies.
资助项目	Chinese NSFCNational Natural Science Foundation of China (NSFC) [31701167]; doctoral research starting foundation [YDBK2018-57]
出版者	E-CENTURY PUBLISHING CORP
出版地	MADISON
ISSN	2156-6976
卷号	10 期号:10 页码:3106-3126
页数	21
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000583897900003
收录类别	SCIE ; PUBMED
URL	查看原文
Pubmed记录号	33163260
PMC记录号	PMC7642655
ESI高被引论文	2024-03 ; 2024-05
通讯作者地址	[Jin, Hongchuan]Zhejiang Univ, Sch Med, Lab Canc Biol, Key Lab Biotherapy Zhejiang,Sir Run Run Shaw Hosp, Hangzhou 310016, Zhejiang, Peoples R China. ; [Zhou, Qiyin]Zhejiang Univ, Dept Med Oncol, Sir Run Run Shaw Hosp, Sch Med, Hangzhou 310016, Zhejiang, Peoples R China.
引用统计	被引频次：72[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/6579
专题	其他_附属东阳医院（东阳市人民医院）
通讯作者	Zhou, Qiyin; Jin, Hongchuan
作者单位	1.Zhejiang Univ, Sch Med, Lab Canc Biol, Key Lab Biotherapy Zhejiang,Sir Run Run Shaw Hosp, Hangzhou 310016, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Dept Pathol, Affiliated Dongyang Hosp, Dongyang 322100, Zhejiang, Peoples R China; 3.Yanan Univ, Coll Life Sci, Yanan 716000, Shaanxi, Peoples R China; 4.Zhejiang Univ, Inst Translat Med, Sch Med, Hangzhou 310029, Zhejiang, Peoples R China; 5.Zhejiang Univ, Dept Med Oncol, Sir Run Run Shaw Hosp, Sch Med, Hangzhou 310016, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Lin, Wenyu,Wang, Chaoqun,Liu, Guangping,et al. SLC7A11/xCT in cancer: biological functions and therapeutic implications[J]. AMERICAN JOURNAL OF CANCER RESEARCH,2020,10(10):3106-3126.
APA	Lin, Wenyu., Wang, Chaoqun., Liu, Guangping., Bi, Chao., Wang, Xian., ... & Jin, Hongchuan. (2020). SLC7A11/xCT in cancer: biological functions and therapeutic implications. AMERICAN JOURNAL OF CANCER RESEARCH, 10(10), 3106-3126.
MLA	Lin, Wenyu,et al."SLC7A11/xCT in cancer: biological functions and therapeutic implications".AMERICAN JOURNAL OF CANCER RESEARCH 10.10(2020):3106-3126.