TBBPA chronic exposure produces sex-specific neurobehavioral and social interaction changes in adult zebrafish

doi:10.1016/j.ntt.2016.05.008

科研成果详情

题名	TBBPA chronic exposure produces sex-specific neurobehavioral and social interaction changes in adult zebrafish
作者	Chen, Jiangfei1,2; Tanguay, Robert L.3; Simonich, Michael 3; Nie, Shangfei 2; Zhao, Yuxin 2; Li, Lelin 2; Bai, Chenglian2; Dong, Qiaoxiang2; Huang, Changjiang 2; Lin, Kuangfei 1
发表日期	2016-07
发表期刊	NEUROTOXICOLOGY AND TERATOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Zebrafish TBBPA Chronic exposure Adult behavior Mirror attack
其他关键词	BROMINATED FLAME RETARDANTS ; TETRABROMOBISPHENOL-A TBBPA ; DANIO-RERIO ; BISPHENOL-A ; TOXICITY ; RATS ; NEUROTOXICITY ; METABOLISM ; BEHAVIOR ; DEFICITS
摘要	The toxicity of tetrabromobisphenol A (TBBPA) has been extensively studied because of its high production volume. TBBPA is toxic to aquatic fish based on acute high concentration exposure tests, and few studies have assessed the behavioral effects of low concentration chronic TBBPA exposures in aquatic organisms. The present study defined the developmental and neurobehavioral effects associated with exposure of zebrafish to 0, 5 and 50 nM TBBPA during 1-120 days post-fertilization (dpf) following by detoxification for four months before the behaviors assessment. These low concentration TBBPA exposures were not associated with malformations and did not alter sex ratio, but resulted in reduced zebrafish body weight and length. Adult behavioral assays indicated that TBBPA exposed males had significantly higher average swim speeds and spent significantly more time in high speed darting mode and less time in medium cruising mode compared to control males. In an adult photomotor response assay, TBBPA exposure was associated with hyperactivity in male fish. Female zebrafish responses in these assays followed a similar trend, but the magnitude of TBBPA effects was generally smaller than in males. Social interaction evaluated using a mirror attack test showed that 50 nM TBBPA exposed males had heightened aggression. Females exposed to 50 nM TBBPA spent more time in the vicinity of the mirror, but did not show increased aggression toward the mirror compared to unexposed control fish. Overall, the hyperactivity and social behavior deficits ascribed here to chronic TBBPA exposure was most profound in males. Our findings indicate that TBBPA can cause developmental and neurobehavioral deficits, and may pose significant health risk to humans. (C) 2016 Elsevier Inc All rights reserved.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21307096]; National Environmental Protection Public Welfare Science and Technology Research Program of China [201309047]; US EPA STAR grantUnited States Environmental Protection Agency [R835796]
出版者	PERGAMON-ELSEVIER SCIENCE LTD
出版地	OXFORD
ISSN	0892-0362
EISSN	1872-9738
卷号	56 页码:9-15
DOI	10.1016/j.ntt.2016.05.008
页数	7
WOS类目	Neurosciences ; Toxicology
WOS研究方向	Neurosciences & Neurology ; Toxicology
WOS记录号	WOS:000380627900002
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27221227
SCOPUSEID	2-s2.0-84973363519
通讯作者地址	[Huang, Changjiang]Zhejiang Provincial Key Lab for Technology and Application of Model Organisms,Institute of Environmental Safety and Human Health,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Toxicology;Developmental Neuroscience;Cellular and Molecular Neuroscience
引用统计	被引频次：34[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/6532
专题	公共卫生学院_健康与环境生态研究所公共卫生学院_环境安全与健康风险评估研究院
通讯作者	Huang, Changjiang
作者单位	1.State Environmental Protection Key Laboratory of Environmental Risk Assessment,Control on Chemical Process,School of Resources and Environmental Engineering,East China University of Science and Technology,No. 130, Mei Long Road,Shanghai,200237,China; 2.Zhejiang Provincial Key Lab for Technology and Application of Model Organisms,Institute of Environmental Safety and Human Health,Wenzhou Medical University,Wenzhou,325035,China; 3.Environmental and Molecular Toxicology,The Sinnhuber Aquatic Research Laboratory,The Environmental Health Sciences Center,Oregon State University,Corvallis,97333,United States
第一作者单位	环境安全与健康风险评估研究院
通讯作者单位	环境安全与健康风险评估研究院
推荐引用方式 GB/T 7714	Chen, Jiangfei,Tanguay, Robert L.,Simonich, Michael,et al. TBBPA chronic exposure produces sex-specific neurobehavioral and social interaction changes in adult zebrafish[J]. NEUROTOXICOLOGY AND TERATOLOGY,2016,56:9-15.
APA	Chen, Jiangfei., Tanguay, Robert L.., Simonich, Michael., Nie, Shangfei., Zhao, Yuxin., ... & Lin, Kuangfei. (2016). TBBPA chronic exposure produces sex-specific neurobehavioral and social interaction changes in adult zebrafish. NEUROTOXICOLOGY AND TERATOLOGY, 56, 9-15.
MLA	Chen, Jiangfei,et al."TBBPA chronic exposure produces sex-specific neurobehavioral and social interaction changes in adult zebrafish".NEUROTOXICOLOGY AND TERATOLOGY 56(2016):9-15.