The effects of individualized therapeutic programs on chronic hepatitis C and the influential factors of virological response

科研成果详情

题名	The effects of individualized therapeutic programs on chronic hepatitis C and the influential factors of virological response
作者	Mao-liang Cheng; Jue Wang; Ai-ping Zeng; Xue-feng Liu
发表日期	2012-10-01
发表期刊	Zhonghua nei ke za zhi 影响因子和分区
语种	英语
原始文献类型	English Abstract ; Journal Article
摘要	Objective: To investigate the effect of individualized therapeutic programs with combination of interferon and ribavirin (RBV) in chronic hepatitis C (CHC) and study the influential factors of virological response rates. Methods: A total of 139 patients with CHC were enrolled and given the intensive treatment doses of interferon and RBV according to their basic clinical condition. At the treatment of 0, 4, 12, 24 weeks, the end of treatment and 24 weeks after treatment stop, the serum HCV RNA was determined. Timely adjustment to dosage and time periods was made according to the virological response to treatment, and the predictive value of rapid virological response (RVR) and complete early virological response (cEVR) for sustained virological response (SVR) were analyzed. Results: At the 4th week of treatment, the level of serum HCV RNA was monitored in 120 patients, and 84.2% (101/120) of patients obtained RVR; among them, 90.7% (88/97) obtained SVR. The virus load of patients obtained RVR at pretherapy was lower than that of patients didn't obtained RVR [(5.883 ± 1.246) lg copies/ml vs(6.502 ± 0.693) lg copies/ml, P = 0.034]. The RVR rate of initial treatment patients with PEG-IFNα-2a [87.8% (79/90)] was significantly higher than that of retreatment patients with PEG-IFNα-2a [65.0% (13/20)] (P = 0.031). At the 12th week of treatment, the level of serum HCV RNA was monitored in 132 patients, and 92.4% (122/132) of patients obtained cEVR; among them, 90.8% (108/119) obtained SVR. The SVR rate of patients obtained cEVR was significantly higher than that of patients didn't obtained cEVR (5/9) (P = 0.007). There was no significant difference between the cEVR rate of initial treatment patients [94.7% (90/95)] and retreatment patients [85% (17/20)] with PEG-IFNα-2a (P = 0.158). Conclusions: cEVR was predictor of SVR. Individualized therapy can increase the obtaining probability of RVR, cEVR and SVR. Adjusting drug dose timely and extending treatment period of HCV RNA-negative based on virological response to treatment are important in CHC individualized therapy.
ISSN	0578-1426
卷号	51 期号:10 页码:751-4.
收录类别	PUBMED
URL	查看原文
Pubmed记录号	23290969
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/63631
专题	其他_附属温岭医院（温岭市第一人民医院）
作者单位	Department of Clinical Laboratory, the Affiliated Wenling Hospital of Wenzhou Medical College, Zhejiang 317500, China.
第一作者单位	附属温岭医院（温岭市第一人民医院）; 临床检验诊断学; 临床检验诊断学
第一作者的第一单位	附属温岭医院（温岭市第一人民医院）
推荐引用方式 GB/T 7714	Mao-liang Cheng,Jue Wang,Ai-ping Zeng,et al. The effects of individualized therapeutic programs on chronic hepatitis C and the influential factors of virological response[J]. Zhonghua nei ke za zhi,2012,51(10):751-4..
APA	Mao-liang Cheng, Jue Wang, Ai-ping Zeng, & Xue-feng Liu. (2012). The effects of individualized therapeutic programs on chronic hepatitis C and the influential factors of virological response. Zhonghua nei ke za zhi, 51(10), 751-4..
MLA	Mao-liang Cheng,et al."The effects of individualized therapeutic programs on chronic hepatitis C and the influential factors of virological response".Zhonghua nei ke za zhi 51.10(2012):751-4..