The associations of methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms and ulcerative colitis

科研成果详情

题名	The associations of methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms and ulcerative colitis
作者	Chang-long Xu; Xiu-qing Lin; De-yun Lan; Jian-zhang Wang; Bo Zheng; Zhan-xiong Xue
发表日期	2011-05-01
发表期刊	Zhonghua nei ke za zhi 影响因子和分区
语种	英语
原始文献类型	Article
摘要	Objective: To investigate the association between the genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and ulcerative colitis (UC) of Han ethnic population in Zhejiang, China. Methods: Two hundred and seventy-four consecutive patients with UC and 726 healthy controls (HC) were studied. The genetic polymorphisms of MTHFR (C677T and A1298C) were genotyped using PCR-RELP methods. Results: The frequencies of variant allele and genotype in MTHFR A1298C gene were higher in UC patients than in the HC (35.77% vs 29.96%, P = 0.013; 52.19% vs 44.90%, P = 0.039; respectively). However, there were no significant discrepancies of the allele and genotype frequencies in the MTHFR C677T gene between the UC patients and the HC (P > 0.05). In addition, the MTHFR 677TT homozygote, T allele and 677CT/1298AC compound genotype were more prevalent in patients with extensive colitis than in those with distal colitis (37.66% vs 14.72%, P = 0.0002; 49.35% vs 32.99%, P = 0.0004; 29.87% vs 15.23%, P = 0.006; respectively). Furthermore, the variant allele in the MTHFR A1298C gene (C) in severe UC patients was significantly lower than in mild and moderate UC patients (18.97% vs 33.88%, P = 0.022). Conclusion: The genetic polymorphisms of MTHFR C677T and A1298C are obviously associated with Han ethnic population with UC in Zhejiang province.
ISSN	0578-1426
卷号	50 期号:5 页码:374-7.
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	21624217
SCOPUSEID	2-s2.0-84555189358
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/63484
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_消化内科
作者单位	Department of Gastroenterology, Wenzhou Medical College, Wenzhou 325027, China.
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_消化内科
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_消化内科
推荐引用方式 GB/T 7714	Chang-long Xu,Xiu-qing Lin,De-yun Lan,et al. The associations of methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms and ulcerative colitis[J]. Zhonghua nei ke za zhi,2011,50(5):374-7..
APA	Chang-long Xu, Xiu-qing Lin, De-yun Lan, Jian-zhang Wang, Bo Zheng, & Zhan-xiong Xue. (2011). The associations of methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms and ulcerative colitis. Zhonghua nei ke za zhi, 50(5), 374-7..
MLA	Chang-long Xu,et al."The associations of methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms and ulcerative colitis".Zhonghua nei ke za zhi 50.5(2011):374-7..